Author, as appears in the article.: Espinel-Ingroff, A.; Colombo, A. L.; Cordoba, S.; Dufresne, P. J.; Fuller, J.; Ghannoum, M.; Gonzalez, G. M.; Guarro, J.; Kidd, S. E.; Meis, J. F.; Melhem, T. M. S. C.; Pelaez, T.; Pfaller, M. A.; Szeszs, M. W.; Takahaschi, J. P.; Tortorano, A. M.; Wiederhold, N. P.; Turnidger, J.;
Department: Ciències Mèdiques Bàsiques
URV's Author/s: Guarro Artigas, Josep
Keywords: Voriconazole Spp. Resistance Posaconazole Multicenter Itraconazole Invasive fusariosis Infections In-vitro Amphotericin-b
Abstract: The CLSI epidemiological cutoff values (ECVs) of antifungal agents are available for various Candida spp., Aspergillus spp., and the Mucorales. However, those categorical endpoints have not been established for Fusarium spp., mostly due to the difficulties associated with collecting sufficient CLSI MICs for clinical isolates identified according to the currently recommended molecular DNA-PCR-based identification methodologies. CLSI MIC distributions were established for 53 Fusarium dimerum species complex (SC), 10 F. fujikuroi, 82 F. proliferatum, 20 F. incarnatum-F. equiseti SC, 226 F. oxysporum SC, 608 F. solani SC, and 151 F. verticillioides isolates originating in 17 laboratories (in Argentina, Australia, Brazil, Canada, Europe, Mexico, and the United States). According to the CLSI guidelines for ECV setting, ECVs encompassing >= 97.5% of pooled statistically modeled MIC distributions were as follows: for amphotericin B, 4 mu g/ml (F. verticillioides) and 8 mu g/ml (F. oxysporum SC and F. solani SC); for posaconazole, 2 mu g/ml (F. verticillioides), 8 mu g/ml (F. oxysporum SC), and 32 mu g/ml (F. solani SC); for voriconazole, 4 mu g/ml (F. verticillioides), 16 mu g/ml (F. oxysporum SC), and 32 mu g/ml (F. solani SC); and for itraconazole, 32 mu g/ml (F. oxysporum SC and F. solani SC). Insufficient data precluded ECV definition for the other species. Although these ECVs could aid in detecting non-wild-type isolates with reduced susceptibility to the agents evaluated, the relationship between molecular mechanisms of resistance (gene mutations) and MICs still needs to be investigated for Fusarium spp.
Thematic Areas: Saúde coletiva Química Pharmacology (medical) Pharmacology & pharmacy Pharmacology Odontología Nutrição Microbiology Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Infectious diseases Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 00664804
Author's mail: josep.guarro@urv.cat
Author identifier: 0000-0002-7839-7568
Record's date: 2024-07-20
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://journals.asm.org/doi/10.1128/aac.02456-15
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Antimicrobial Agents And Chemotherapy. 60 (2): 1079-1084
APA: Espinel-Ingroff, A.; Colombo, A. L.; Cordoba, S.; Dufresne, P. J.; Fuller, J.; Ghannoum, M.; Gonzalez, G. M.; Guarro, J.; Kidd, S. E.; Meis, J. F.; Me (2016). International Evaluation of MIC Distributions and Epidemiological Cutoff Value (ECV) Definitions for Fusarium Species Identified by Molecular Methods for the CLSI Broth Microdilution Method. Antimicrobial Agents And Chemotherapy, 60(2), 1079-1084. DOI: 10.1128/AAC.02456-15
Article's DOI: 10.1128/AAC.02456-15
Entity: Universitat Rovira i Virgili
Journal publication year: 2016
Publication Type: Journal Publications