Efficient synthesis of chiral γ-aminobutyric esters: Via direct rhodium-catalysed enantioselective hydroaminomethylation of acrylates

Identifier:  imarina:6112283

Handle: https://hdl.handle.net/20.500.11797/imarina6112283

Authors:  Cunillera, A; de los Bernardos, MD; Urrutigoïty, M; Claver, C; Ruiz, A; Godard, C

Abstract:
This journal is © The Royal Society of Chemistry. The successful rhodium catalysed asymmetric intermolecular hydroaminomethylation (HAM) of alkenes using a single catalyst bearing the (R,R)-QuinoxP∗ ligand is reported. The HAM of α-alkyl acrylates is revealed to be an efficient tool for the regio- and enantioselective synthesis of γ-amino esters with ees up to 86%. HPNMR experiments provided insights into the reaction mechanism.