Author, as appears in the article.: Perez-Fernandez C; Morales-Navas M; Aguilera-Sáez LM; Abreu AC; Guardia-Escote L; Fernández I; Garrido-Cárdenas JA; Colomina MT; Giménez E; Sánchez-Santed F
Department: Bioquímica i Biotecnologia Psicologia
URV's Author/s: Colomina Fosch, Maria Teresa / Guardia Escoté, Laia
Keywords: Subchronic exposure Sociability Serum Rats Organophosphate insecticide chlorpyrifos Neurotoxicity Neonatal exposure Metabolomics Hyperlipidemia Gut microbiota Female mice Evidence of approval (animals) Dominance Development Chlorpyrifos Autism spectrum disorders Asd metabolomics gut microbiota evidence of approval (animals) dominance development chlorpyrifos asd
Abstract: © 2020 Elsevier Inc. Autism spectrum disorder (ASD) is a complex neurodevelopmental pathology characterized by altered verbalizations, reduced social interaction behavior, and stereotypies. Environmental factors have been associated with its development. Some researchers have focused on pesticide exposure. Chlorpyrifos (CPF) is the most used Organophosphate. Previous developmental studies with CPF showed decreased, enhanced or no effect on social outcomes eminently in mice. The study of CPF exposure during preweaning stages on social behavior is sparse in mice and non-existent in rats. d stressors could be at the basis of ASD development, and around postnatal day 10 in the rat is equivalent to the human birthday in neurodevelopmental terms. We explored the effects of exposure to low doses (1mg/kg/mL/day) of CPF during this stage regarding: sociability, dominance gut microbiome and plasma metabolomic profile, since alterations in these systems have also been linked to ASD. There was a modest influence of CPF on social behavior in adulthood, with null effects during adolescence. Dominance and hierarchical status were not affected by exposure. Dominance status explained the significant reduction in reaction to social novelty observed on the sociability test. CPF induced a significant gut microbiome dysbiosis and triggered a hyperlipidemic, hypoglycemic/hypogluconeogenesis and a general altered cell energy production in females. These behavioral results in rats extend and complement previous studies with mice and show novel influences on gut metagenomics and plasma lipid profile and metabolomics, but do not stablish a relation between the exposure to CPF and the ASD phenotype. The effects of dominance status on reaction to social novelty have an important methodological meaning for future research on sociability.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Public, environmental & occupational health Psicología Planejamento urbano e regional / demografia Odontología Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Geociências General medicine General environmental science Farmacia Environmental sciences Environmental science (miscellaneous) Environmental science (all) Ensino Engenharias iii Engenharias ii Engenharias i Enfermagem Educação física Direito Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Biochemistry Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 00139351
Author's mail: mariateresa.colomina@urv.cat
Author identifier: 0000-0002-5619-4874
Record's date: 2023-02-22
Journal volume: 184
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S0013935120302346?via%3Dihub
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Environmental Research. 184 (109341): 109341-
APA: Perez-Fernandez C; Morales-Navas M; Aguilera-Sáez LM; Abreu AC; Guardia-Escote L; Fernández I; Garrido-Cárdenas JA; Colomina MT; Giménez E; Sánchez-Sa (2020). Medium and long-term effects of low doses of Chlorpyrifos during the postnatal, preweaning developmental stage on sociability, dominance, gut microbiota and plasma metabolites. Environmental Research, 184(109341), 109341-. DOI: 10.1016/j.envres.2020.109341
Article's DOI: 10.1016/j.envres.2020.109341
Entity: Universitat Rovira i Virgili
Journal publication year: 2020
Publication Type: Journal Publications
Repositori URV