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Medium and long-term effects of low doses of Chlorpyrifos during the postnatal, preweaning developmental stage on sociability, dominance, gut microbiota and plasma metabolites

  • Identification data

    Identifier: imarina:6159133
    Authors:
    Perez-Fernandez CMorales-Navas MAguilera-Sáez LMAbreu ACGuardia-Escote LFernández IGarrido-Cárdenas JAColomina MTGiménez ESánchez-Santed F
    Abstract:
    © 2020 Elsevier Inc. Autism spectrum disorder (ASD) is a complex neurodevelopmental pathology characterized by altered verbalizations, reduced social interaction behavior, and stereotypies. Environmental factors have been associated with its development. Some researchers have focused on pesticide exposure. Chlorpyrifos (CPF) is the most used Organophosphate. Previous developmental studies with CPF showed decreased, enhanced or no effect on social outcomes eminently in mice. The study of CPF exposure during preweaning stages on social behavior is sparse in mice and non-existent in rats. d stressors could be at the basis of ASD development, and around postnatal day 10 in the rat is equivalent to the human birthday in neurodevelopmental terms. We explored the effects of exposure to low doses (1mg/kg/mL/day) of CPF during this stage regarding: sociability, dominance gut microbiome and plasma metabolomic profile, since alterations in these systems have also been linked to ASD. There was a modest influence of CPF on social behavior in adulthood, with null effects during adolescence. Dominance and hierarchical status were not affected by exposure. Dominance status explained the significant reduction in reaction to social novelty observed on the sociability test. CPF induced a significant gut microbiome dysbiosis and triggered a hyperlipidemic, hypoglycemic/hypogluconeogenesis and a general altered cell energy production in females. These behavioral results in rats extend and complement previous studies with mice and show novel influences on gut metagenomics and plasma lipid profile and metabolomics, but do not stablish a relation between the exposure to CPF and the ASD phenotype. The effects of dominance status on reaction to social novelty have an important methodological mea
  • Others:

    Author, as appears in the article.: Perez-Fernandez C; Morales-Navas M; Aguilera-Sáez LM; Abreu AC; Guardia-Escote L; Fernández I; Garrido-Cárdenas JA; Colomina MT; Giménez E; Sánchez-Santed F
    Department: Bioquímica i Biotecnologia Psicologia
    URV's Author/s: Colomina Fosch, Maria Teresa / Guardia Escoté, Laia
    Keywords: Subchronic exposure Sociability Serum Rats Organophosphate insecticide chlorpyrifos Neurotoxicity Neonatal exposure Metabolomics Hyperlipidemia Gut microbiota Female mice Evidence of approval (animals) Dominance Development Chlorpyrifos Autism spectrum disorders Asd metabolomics gut microbiota evidence of approval (animals) dominance development chlorpyrifos asd
    Abstract: © 2020 Elsevier Inc. Autism spectrum disorder (ASD) is a complex neurodevelopmental pathology characterized by altered verbalizations, reduced social interaction behavior, and stereotypies. Environmental factors have been associated with its development. Some researchers have focused on pesticide exposure. Chlorpyrifos (CPF) is the most used Organophosphate. Previous developmental studies with CPF showed decreased, enhanced or no effect on social outcomes eminently in mice. The study of CPF exposure during preweaning stages on social behavior is sparse in mice and non-existent in rats. d stressors could be at the basis of ASD development, and around postnatal day 10 in the rat is equivalent to the human birthday in neurodevelopmental terms. We explored the effects of exposure to low doses (1mg/kg/mL/day) of CPF during this stage regarding: sociability, dominance gut microbiome and plasma metabolomic profile, since alterations in these systems have also been linked to ASD. There was a modest influence of CPF on social behavior in adulthood, with null effects during adolescence. Dominance and hierarchical status were not affected by exposure. Dominance status explained the significant reduction in reaction to social novelty observed on the sociability test. CPF induced a significant gut microbiome dysbiosis and triggered a hyperlipidemic, hypoglycemic/hypogluconeogenesis and a general altered cell energy production in females. These behavioral results in rats extend and complement previous studies with mice and show novel influences on gut metagenomics and plasma lipid profile and metabolomics, but do not stablish a relation between the exposure to CPF and the ASD phenotype. The effects of dominance status on reaction to social novelty have an important methodological meaning for future research on sociability.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Public, environmental & occupational health Public health, environmental and occupational health Psicología Planejamento urbano e regional / demografia Odontología Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Geociências General medicine General environmental science Farmacia Environmental sciences Environmental science (miscellaneous) Environmental science (all) Ensino Engenharias iii Engenharias ii Engenharias i Enfermagem Educação física Direito Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Biochemistry Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 00139351
    Author's mail: mariateresa.colomina@urv.cat
    Author identifier: 0000-0002-5619-4874
    Record's date: 2024-07-27
    Journal volume: 184
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S0013935120302346?via%3Dihub
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Environmental Research. 184 (109341): 109341-
    APA: Perez-Fernandez C; Morales-Navas M; Aguilera-Sáez LM; Abreu AC; Guardia-Escote L; Fernández I; Garrido-Cárdenas JA; Colomina MT; Giménez E; Sánchez-Sa (2020). Medium and long-term effects of low doses of Chlorpyrifos during the postnatal, preweaning developmental stage on sociability, dominance, gut microbiota and plasma metabolites. Environmental Research, 184(109341), 109341-. DOI: 10.1016/j.envres.2020.109341
    Article's DOI: 10.1016/j.envres.2020.109341
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2020
    Publication Type: Journal Publications
  • Keywords:

    Biochemistry,Environmental Science (Miscellaneous),Environmental Sciences,Public, Environmental & Occupational Health
    Subchronic exposure
    Sociability
    Serum
    Rats
    Organophosphate insecticide chlorpyrifos
    Neurotoxicity
    Neonatal exposure
    Metabolomics
    Hyperlipidemia
    Gut microbiota
    Female mice
    Evidence of approval (animals)
    Dominance
    Development
    Chlorpyrifos
    Autism spectrum disorders
    Asd
    metabolomics
    gut microbiota
    evidence of approval (animals)
    dominance
    development
    chlorpyrifos
    asd
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Public, environmental & occupational health
    Public health, environmental and occupational health
    Psicología
    Planejamento urbano e regional / demografia
    Odontología
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Geociências
    General medicine
    General environmental science
    Farmacia
    Environmental sciences
    Environmental science (miscellaneous)
    Environmental science (all)
    Ensino
    Engenharias iii
    Engenharias ii
    Engenharias i
    Enfermagem
    Educação física
    Direito
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biodiversidade
    Biochemistry
    Astronomia / física
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