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Human Serum/Plasma Glycoprotein Analysis by H-1-NMR, an Emerging Method of Inflammatory Assessment

  • Identification data

    Identifier: imarina:6170410
    Authors:
    Fuertes-Martin, RocioCorreig, XavierVallve, Joan-CarlesAmigo, Nuria
    Abstract:
    Several studies suggest that variations in the concentration of plasma glycoproteins can influence cellular changes in a large number of diseases. In recent years, proton nuclear magnetic resonance (H-1-NMR) has played a major role as an analytical tool for serum and plasma samples. In recent years, there is an increasing interest in the characterization of glycoproteins through H-1-NMR in order to search for reliable and robust biomarkers of disease. The objective of this review was to examine the existing studies in the literature related to the study of glycoproteins from an analytical and clinical point of view. There are currently several techniques to characterize circulating glycoproteins in serum or plasma, but in this review, we focus on H-1-NMR due to its great robustness and recent interest in its translation to the clinical setting. In fact, there is already a marker in H-NMR representing the acetyl groups of the glycoproteins, GlycA, which has been increasingly studied in clinical studies. A broad search of the literature was performed showing a general consensus that GlycA is a robust marker of systemic inflammation. The results also suggested that GlycA better captures systemic inflammation even more than C-reactive protein (CRP), a widely used classical inflammatory marker. The applications reviewed here demonstrated that GlycA was potentially a key biomarker in a wide range of diseases such as cancer, metabolic diseases, cardiovascular risk, and chronic inflammatory diseases among others. The profiling of glycoproteins through H-1-NMR launches an encouraging new paradigm for its future incorporation in clinical diagnosis.
  • Others:

    Author, as appears in the article.: Fuertes-Martin, Rocio; Correig, Xavier; Vallve, Joan-Carles; Amigo, Nuria;
    Department: Enginyeria Electrònica, Elèctrica i Automàtica
    URV's Author/s: Correig Blanchar, Francesc Xavier / Vallvé Torrente, Joan Carles
    Keywords: Type-2 diabetes-mellitus Systemic inflammation Rheumatoid-arthritis Nuclear-magnetic-resonance Nag Nac N-glycosylation status Metabonomic signature analysis Inflammation H-1-nmr Glycoprotein Glyca Future cardiovascular events C-reactive protein Alpha-1-acid glycoprotein Acute-phase proteins 1 h-nmr nag nac glycoprotein glyca 1h-nmr
    Abstract: Several studies suggest that variations in the concentration of plasma glycoproteins can influence cellular changes in a large number of diseases. In recent years, proton nuclear magnetic resonance (H-1-NMR) has played a major role as an analytical tool for serum and plasma samples. In recent years, there is an increasing interest in the characterization of glycoproteins through H-1-NMR in order to search for reliable and robust biomarkers of disease. The objective of this review was to examine the existing studies in the literature related to the study of glycoproteins from an analytical and clinical point of view. There are currently several techniques to characterize circulating glycoproteins in serum or plasma, but in this review, we focus on H-1-NMR due to its great robustness and recent interest in its translation to the clinical setting. In fact, there is already a marker in H-NMR representing the acetyl groups of the glycoproteins, GlycA, which has been increasingly studied in clinical studies. A broad search of the literature was performed showing a general consensus that GlycA is a robust marker of systemic inflammation. The results also suggested that GlycA better captures systemic inflammation even more than C-reactive protein (CRP), a widely used classical inflammatory marker. The applications reviewed here demonstrated that GlycA was potentially a key biomarker in a wide range of diseases such as cancer, metabolic diseases, cardiovascular risk, and chronic inflammatory diseases among others. The profiling of glycoproteins through H-1-NMR launches an encouraging new paradigm for its future incorporation in clinical diagnosis.
    Thematic Areas: Medicine, general & internal Medicine (miscellaneous) Medicine (all)
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 20770383
    Author's mail: jc.vallve@urv.cat jc.vallve@urv.cat xavier.correig@urv.cat
    Author identifier: 0000-0002-6902-3054
    Record's date: 2024-10-26
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/2077-0383/9/2/354
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Journal Of Clinical Medicine. 9 (2):
    APA: Fuertes-Martin, Rocio; Correig, Xavier; Vallve, Joan-Carles; Amigo, Nuria; (2020). Human Serum/Plasma Glycoprotein Analysis by H-1-NMR, an Emerging Method of Inflammatory Assessment. Journal Of Clinical Medicine, 9(2), -. DOI: 10.3390/jcm9020354
    Article's DOI: 10.3390/jcm9020354
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2020
    Publication Type: Journal Publications
  • Keywords:

    Medicine (Miscellaneous),Medicine, General & Internal
    Type-2 diabetes-mellitus
    Systemic inflammation
    Rheumatoid-arthritis
    Nuclear-magnetic-resonance
    Nag
    Nac
    N-glycosylation status
    Metabonomic signature analysis
    Inflammation
    H-1-nmr
    Glycoprotein
    Glyca
    Future cardiovascular events
    C-reactive protein
    Alpha-1-acid glycoprotein
    Acute-phase proteins
    1 h-nmr
    nag
    nac
    glycoprotein
    glyca
    1h-nmr
    Medicine, general & internal
    Medicine (miscellaneous)
    Medicine (all)
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