New Oral Anticoagulants vs Vitamin K Antagonists: Benefits for Health-Related Quality of Life in Patients with Atrial Fibrillation

Identifier:  imarina:6185073

Handle: https://hdl.handle.net/20.500.11797/imarina6185073

Authors:  Alegret, Josep M; Vinolas, Xavier; Arias, Miguel A; Martinez-Rubio, Antoni; Rebollo, Pablo; Rafols, Carles; Martinez-Sande, Jose L

Abstract:
New oral anticoagulants (NOAC) have demonstrated their efficacy as an alternative to vitamin K antagonists (VKA) in the prophylaxis of cardioembolic events in patients with atrial fibrillation (AF). However, evidence on the benefits of NOAC in health-related quality of life (HRQoL) is lacking. We evaluated changes in HRQoL related to oral anticoagulation therapy employing a specific questionnaire in a cohort of 416 patients with AF undergoing electrical cardioversion. In terms of HRQoL, we observed a progressive adaptation to treatment with VKA; satisfaction with NOAC remained constant. Older age, higher left ventricular ejection fraction and NOAC were associated with better HRQoL.