Author, as appears in the article.: Baca Garcia, Enrique; Fernandez Piqueras, Jose; Gratacos, Monica; Costas, Javier; de Cid, Rafael; Bayes, Monica; Gonzalez, Juan R; de Diego, Yolanda; Fernandez-Aranda, Fernando; Guitart, Miriam; Martin-Santos, Rocio; Menchon, Jose M; Roca, Miquel; Saiz-Ruiz, Jeronimo; Sanjuan, Julio; Torrens, Marta; Urretavizcaya, Mikel; Valero, Joaquin; Estivill, Xavier; Carracedo, Angel
Department: Medicina i Cirurgia Medicina i Cirurgia Medicina i Cirurgia
URV's Author/s: Martorell Bonet, Lourdes / Valero Oyarzabal, Joaquín Silvestre / Vilella Cuadrada, Elisabet
Keywords: Snp Panic disorder Multiple-sclerosis Molecular epidemiology Mental disorders Major depression Linkage disequilibrium Esquizofrenia Differential-diagnosis Case-control studies Candidate gene Association study
Abstract: A fundamental difficulty in human genetics research is the identification of the spectrum of genetic variants that contribute to the susceptibility to common/complex disorders. We tested here the hypothesis that functional genetic variants may confer susceptibility to several related common disorders. We analyzed five main psychiatric diagnostic categories (substance-abuse, anxiety, eating, psychotic, and mood disorders) and two different control groups, representing a total of 3,214 samples, for 748 promoter and non-synonymous single nucleotide polymorphisms (SNPs) at 306 genes involved in neurotransmission and/or neurodevelopment. We identified strong associations to individual disorders, such as growth hormone releasing hormone (GHRH) with anxiety disorders, prolactin regulatory element (PREB) with eating disorders, ionotropic kainate glutamate receptor 5 (GRIK5) with bipolar disorder and several SNPs associated to several disorders, that may represent individual and related disease susceptibility factors. Remarkably, a functional SNP, rs945032, located in the promoter region of the bradykinin receptor B2 gene (BDKRB2) was associated to three disorders (panic disorder, substance abuse, and bipolar disorder), and two additional BDKRB2 SNPs to obsessive-compulsive disorder and major depression, providing evidence for common variants of susceptibility to several related psychiatric disorders. The association of BDKRB2 (odd ratios between 1.65 and 3.06) to several psychiatric disorders supports the view that a common genetic variant could confer susceptibility to clinically related phenotypes, and defines a new functional hint in the pathophysiology of psychiatric diseases.(c) 2008 Wiley-Liss, Inc.
Thematic Areas: Saúde coletiva Psychiatry and mental health Psychiatry Psicología Medicina ii Medicina i Genetics (clinical) Genetics & heredity General medicine Ensino Ciências biológicas ii Ciências biológicas i Cellular and molecular neuroscience Biotecnología Biodiversidade
ISSN: 15524841
Author's mail: joaquinsilvestre.valero@urv.cat lourdes.martorell@urv.cat elisabet.vilella@urv.cat
Author identifier: 0000-0003-4999-2197 0000-0002-1887-5919
Record's date: 2023-02-22
Papper original source: American Journal Of Medical Genetics Part B-Neuropsychiatric Genetics. 150B (6): 808-816
APA: Baca Garcia, Enrique; Fernandez Piqueras, Jose; Gratacos, Monica; Costas, Javier; de Cid, Rafael; Bayes, Monica; Gonzalez, Juan R; de Diego, Yolanda; (2009). Identification of New Putative Susceptibility Genes for Several Psychiatric Disorders by Association Analysis of Regulatory and Non-Synonymous SNPs of 306 Genes Involved in Neurotransmission and Neurodevelopment. American Journal Of Medical Genetics Part B-Neuropsychiatric Genetics, 150B(6), 808-816. DOI: 10.1002/ajmg.b.30902
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Article's DOI: 10.1002/ajmg.b.30902
Entity: Universitat Rovira i Virgili
Journal publication year: 2009
Publication Type: Journal Publications
Repositori URV