Paper-based chemiresistor for detection of ultralow concentrations of protein

Identifier:  imarina:6387409

Handle: https://hdl.handle.net/20.500.11797/imarina6387409

Authors:  Pozuelo, M; Blondeau, P; Novell, M; Andrade, FJ; Rius, FX; Riu, J

Abstract:
A new paper-based chemiresistor composed of a network of single-wall carbon nanotubes (SWCNTs) and anti-human immunoglobulin G (anti-HIgG) is reported herein. SWCNTs act as outstanding transducers because they provide high sensitivity in terms of resistance changes due to immunoreaction. As a result, the resistance-based biosensor reaches concentration detection as low as picomolar. The resulting paper-based biosensor is sensitive, selective and employs low-cost substrate and simple manufacturing stages. Since chemiresistors require low-power equipment and are able to detect low concentrations with inexpensive materials, the present approach may pave the way for the development of resistive biosensors at very low-cost with high performances. © 2013 Elsevier B.V.