Articles producció científica> Medicina i Cirurgia

Efficacy of two interventions on the discontinuation of benzodiazepines in long-term users: 36-month follow-up of a cluster randomised trial in primary care

  • Identification data

    Identifier: imarina:6388542
    Authors:
    Vicens CSempere EBejarano FSocias IMateu CFiol FPalop VLera GMengual MFolch SBasora JLeiva A
    Abstract:
    Background Primary care interventions that promote cessation of benzodiazepine (BZD) use in longterm users are effective at 1 year, but their efficacy at 3 years is uncertain. Aim To assess the 3-year efficacy of two primary care interventions delivered by GPS on cessation of BZD use in long-term users. Design and setting Multicentre, three-arm, cluster randomised, controlled trial, with random allocation at the GP level. Method Seventy-five GPS and 532 patients were randomly allocated to three groups: usual care (control), structured intervention with steppeddose reduction and follow-up visits (SIF), or structured intervention with written steppeddose reduction (SIW). The primary outcome was BZD use at 36 months. Results At 36 months, 66/168 patients (39.2%) in the SIW group, 79/191 patients (41.3%) in the SIF group, and 45/173 patients (26.0%) in the control group had discontinued BZD use. The relative risks (RR) adjusted by cluster were 1.51 (95% CI = 1.10 to 2.05; P = 0.009) in the SIW group and 1.59 (95% CI = 1.15 to 2.19; P = 0.005) in the SIF group. A total of 131/188 patients (69.7%) who successfully discontinued BZD use at 12 months remained abstinent at 36 months. The groups showed no significant differences in anxiety, depression, or sleep dissatisfaction at 36 months. Conclusion The interventions were effective on cessation of BZD use; most patients who discontinued at 12 months remained abstinent at 3 years. Discontinuation of BZD use did not have a significant effect on anxiety, depression, or sleep quality.
  • Others:

    Author, as appears in the article.: Vicens C; Sempere E; Bejarano F; Socias I; Mateu C; Fiol F; Palop V; Lera G; Mengual M; Folch S; Basora J; Leiva A
    Department: Medicina i Cirurgia
    URV's Author/s: Basora Gallisa, Josep
    Keywords: Withdrawal symptoms Primary health care General practice Benzodiazepine Adverse effects primary health care general practice benzodiazepine adverse effects
    Abstract: Background Primary care interventions that promote cessation of benzodiazepine (BZD) use in longterm users are effective at 1 year, but their efficacy at 3 years is uncertain. Aim To assess the 3-year efficacy of two primary care interventions delivered by GPS on cessation of BZD use in long-term users. Design and setting Multicentre, three-arm, cluster randomised, controlled trial, with random allocation at the GP level. Method Seventy-five GPS and 532 patients were randomly allocated to three groups: usual care (control), structured intervention with steppeddose reduction and follow-up visits (SIF), or structured intervention with written steppeddose reduction (SIW). The primary outcome was BZD use at 36 months. Results At 36 months, 66/168 patients (39.2%) in the SIW group, 79/191 patients (41.3%) in the SIF group, and 45/173 patients (26.0%) in the control group had discontinued BZD use. The relative risks (RR) adjusted by cluster were 1.51 (95% CI = 1.10 to 2.05; P = 0.009) in the SIW group and 1.59 (95% CI = 1.15 to 2.19; P = 0.005) in the SIF group. A total of 131/188 patients (69.7%) who successfully discontinued BZD use at 12 months remained abstinent at 36 months. The groups showed no significant differences in anxiety, depression, or sleep dissatisfaction at 36 months. Conclusion The interventions were effective on cessation of BZD use; most patients who discontinued at 12 months remained abstinent at 3 years. Discontinuation of BZD use did not have a significant effect on anxiety, depression, or sleep quality.
    Thematic Areas: Primary health care Medicine, general & internal Medicine (miscellaneous) Medicina ii Family practice Ciência política e relações internacionais
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 09601643
    Author's mail: josep.basora@urv.cat josep.basora@urv.cat
    Record's date: 2024-09-07
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://bjgp.org/content/66/643/e85
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: British Journal Of General Practice. 66 (643): e85-e91
    APA: Vicens C; Sempere E; Bejarano F; Socias I; Mateu C; Fiol F; Palop V; Lera G; Mengual M; Folch S; Basora J; Leiva A (2017). Efficacy of two interventions on the discontinuation of benzodiazepines in long-term users: 36-month follow-up of a cluster randomised trial in primary care. British Journal Of General Practice, 66(643), e85-e91. DOI: 10.3399/bjgp16X683485
    Article's DOI: 10.3399/bjgp16X683485
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2017
    Publication Type: Journal Publications
  • Keywords:

    Family Practice,Medicine (Miscellaneous),Medicine, General & Internal,Primary Health Care
    Withdrawal symptoms
    Primary health care
    General practice
    Benzodiazepine
    Adverse effects
    primary health care
    general practice
    benzodiazepine
    adverse effects
    Primary health care
    Medicine, general & internal
    Medicine (miscellaneous)
    Medicina ii
    Family practice
    Ciência política e relações internacionais
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