Author, as appears in the article.: Auguet, Teresa; Aragones, Gemma; Guiu-Jurado, Esther; Berlanga, Alba; Curriu, Marta; Martinez, Salome; Alibalic, Ajla; Aguilar, Carmen; Camara, Maria-Luisa; Hernandez, Esteban; Ruyra, Xavier; Martin-Paredero, Vicente; Richart, Cristobal
Department: Ciències Mèdiques Bàsiques Medicina i Cirurgia
URV's Author/s: Aguilar Crespillo, Carmen Isabel / AGUILAR MARMOL, CARME / ARAGONÈS BARGALLÓ, GEMMA / Auguet Quintillà, Maria Teresa / BERLANGA BUSTOS, ALBA / GUIU JURADO, ESTHER / Martín Paredero, Vicente / Martínez González, María Salomé / Richart Jurado, Cristobal Manuel
Keywords: Visfatin Secretome Atherosclerosis Atheroma plaque Adipo/cytokines secretome atherosclerosis atheroma plaque adipo/cytokines
Abstract: � 2016 The Author(s). Background: Novel pro-inflammatory and anti-inflammatory derivatives from adipose tissue, known as adipokines, act as metabolic factors. The aim of this study was to analyse the secreted expression of different adipo/cytokines in secretomes of unstable carotid atherosclerotic plaque versus non-atherosclerotic mammary artery. Methods: We evaluated the secretion levels of adiponectin, visfatin, lipocalin-2, resistin, IL-6 and TNFR2 by ELISA in human secretomes from cultured unstable carotid atherosclerotic plaque (n = 18) and non-atherosclerotic mammary artery (n = 13). We also measured visfatin serum levels in patients suffering from atherosclerosis and in a serum cohort of healthy subjects (n = 16). Results: We found that visfatin levels were significantly increased in unstable carotid atherosclerotic plaque secretome than in non-atherosclerotic mammary artery secretome. No differences were found with regard the other adipo/cytokines studied. Regarding visfatin circulating levels, there were no differences between unstable carotid atherosclerotic plaque and non-atherosclerotic mammary artery group. However, these visfatin levels were increased in comparison to serum cohort of healthy subjects. Conclusions: Of all the adipo/cytokines analysed, only visfatin showed increased levels in secretomes of unstable carotid atherosclerotic plaque. Additional human studies are needed to clarify the possible role of visfatin as prognostic factor of unstable carotid atherosclerotic plaque.
Thematic Areas: Saúde coletiva Psicología Medicina iii Medicina ii Medicina i Matemática / probabilidade e estatística Interdisciplinar Farmacia Educação física Ciências biológicas ii Ciências biológicas i Cardiology and cardiovascular medicine Cardiac & cardiovascular systems Biotecnología
ISSN: 14712261
Author's mail: mariasalome.martinez@urv.cat carmenisabel.aguilar@urv.cat carmenisabel.aguilar@urv.cat mariateresa.auguet@urv.cat
Author identifier: 0000-0001-6185-2889 0000-0002-4440-562X 0000-0002-4440-562X 0000-0003-0396-6428
Record's date: 2024-09-28
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://bmccardiovascdisord.biomedcentral.com/articles/10.1186/s12872-016-0320-5
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Bmc Cardiovascular Disorders. 16 (1): 149-
APA: Auguet, Teresa; Aragones, Gemma; Guiu-Jurado, Esther; Berlanga, Alba; Curriu, Marta; Martinez, Salome; Alibalic, Ajla; Aguilar, Carmen; Camara, Maria- (2016). Adipo/cytokines in atherosclerotic secretomes: Increased visfatin levels in unstable carotid plaque. Bmc Cardiovascular Disorders, 16(1), 149-. DOI: 10.1186/s12872-016-0320-5
Article's DOI: 10.1186/s12872-016-0320-5
Entity: Universitat Rovira i Virgili
Journal publication year: 2016
Publication Type: Journal Publications
Repositori URV