Author, as appears in the article.: Auguet, Teresa; Bertran, Laia; Binetti, Jessica; Aguilar, Carmen; Martinez, Salome; Sabench, Fatima; Miguel Lopez-Dupla, Jesus; Antonio Porras, Jose; Riesco, David; Del Castillo, Daniel; Richart, Cristobal
Department: Medicina i Cirurgia
URV's Author/s: Aguilar Crespillo, Carmen Isabel / Auguet Quintillà, Maria Teresa / Bertran Ramos, Laia / Binetti, Jessica Angela / Del Castillo Déjardin, Daniel / López Dupla, Jesús Miguel / Martínez González, María Salomé / Porras Ledantes, Jose Antonio / Richart Jurado, Cristobal Manuel / Riesco Acevedo, David Gerardo / Sabench Pereferrer, Fàtima
Keywords: Toll-like receptors Toll-like receptor 4 Toll-like receptor 2 Tnf-alpha Tlr4 protein, human Tlr2 protein, human Pathogenesis Oxidative stress Obesity, morbid Nonalcoholic steatohepatitis Nonalcoholic fatty liver disease Non-alcoholic fatty liver disease Natural-history Morbid obesity Middle aged Liver Interleukin-8 Insulin-resistance Inflammation Humans Fibrosis Female Fatty liver-disease Cytokines Cxcl8 protein, human Case-control studies Bariatric surgery Adult Adipokines nonalcoholic steatohepatitis nonalcoholic fatty liver disease morbid obesity cytokines
Abstract: The progression of nonalcoholic fatty liver disease (NAFLD) to nonalcoholic steatohepatitis (NASH) is linked to systemic inflammation. Currently, two of the aspects that need further investigation are diagnosis and treatment of NASH. In this sense, the aim of this study was to assess the relationship between circulating levels of cytokines, hepatic expression of toll-like receptors (TLRs), and degrees of NAFLD, and to investigate whether these levels could serve as noninvasive biomarkers of NASH. The present study assessed plasma levels of cytokines in 29 normal-weight women and 82 women with morbid obesity (MO) (subclassified: normal liver (n = 29), simple steatosis (n = 32), and NASH (n = 21)). We used enzyme-linked immunosorbent assays (ELISAs) to quantify cytokine and TLR4 levels and RTqPCR to assess TLRs hepatic expression. IL-1β, IL-8, IL-10, TNF-α, tPAI-1, and MCP-1 levels were increased, and adiponectin levels were decreased in women with MO. IL-8 was significantly higher in MO with NASH than in NL. To sum up, high levels of IL-8 were associated with the diagnosis of NASH in a cohort of women with morbid obesity. Moreover, a positive correlation between TLR2 hepatic expression and IL-8 circulating levels was found.
Thematic Areas: Zootecnia / recursos pesqueiros Spectroscopy Saúde coletiva Química Psicología Physical and theoretical chemistry Organic chemistry Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Inorganic chemistry Geociências Farmacia Engenharias iv Engenharias ii Engenharias i Educação física Computer science applications Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, multidisciplinary Catalysis Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 14220067
Author's mail: davidgerardo.riesco@urv.cat joseantonio.porras@urv.cat mariasalome.martinez@urv.cat danieldel.castillo@urv.cat jessicaangela.binetti@estudiants.urv.cat laia.bertranr@estudiants.urv.cat laia.bertranr@estudiants.urv.cat fatima.sabench@urv.cat carmenisabel.aguilar@urv.cat carmenisabel.aguilar@urv.cat mariateresa.auguet@urv.cat jesusmiguel.lopez@urv.cat
Author identifier: 0000-0001-6418-1822 0000-0001-6185-2889 0000-0003-0456-3102 0000-0001-7024-7824 0000-0001-9660-7752 0000-0001-9052-1368 0000-0001-9052-1368 0000-0002-9262-8756 0000-0002-4440-562X 0000-0002-4440-562X https://orcid.org/0000-0003-0396-6428 0000-0003-0396-6428 0000-0002-9141-2523
Record's date: 2024-12-21
Papper version: info:eu-repo/semantics/publishedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: International Journal Of Molecular Sciences. 21 (11): 1-15
APA: Auguet, Teresa; Bertran, Laia; Binetti, Jessica; Aguilar, Carmen; Martinez, Salome; Sabench, Fatima; Miguel Lopez-Dupla, Jesus; Antonio Porras, Jose; (2020). Relationship between IL-8 Circulating Levels and TLR2 Hepatic Expression in Women with Morbid Obesity and Nonalcoholic Steatohepatitis. International Journal Of Molecular Sciences, 21(11), 1-15. DOI: 10.3390/ijms21114189
Entity: Universitat Rovira i Virgili
Journal publication year: 2020
Publication Type: Journal Publications
Repositori URV