Author, as appears in the article.: Xavier Aviles-Jurado, Francesc; Munoz, Carmen; Meler, Carla; Carles Flores, Joan; Guma, Josep; Benaiges, Ester; Mora, Josefina; Camacho, Mercedes; Leon, Xavier; Vilaseca, Isabel; Terra, Ximena
Department: Bioquímica i Biotecnologia
URV's Author/s: Avilés Jurado, Francisco Javier / Meler Claramonte, Carla / Terra Barbadora, Ximena
Keywords: Suppression Squamous cell carcinoma of head and neck Retrospective studies Proliferation Prognosis Non-invasive biomarker Neoplasm recurrence, local Mirnas Mir-124 Micrornas Humans Head and neck neoplasms Head and neck cancer Head Growth Glycolysis Gene expression regulation, neoplastic Down-regulation Circulating microrna Cancers Biomarkers, tumor Apoptosis Aberrant expression prognosis non-invasive biomarker head and neck cancer glycolysis
Abstract: © 2020, Springer-Verlag GmbH Germany, part of Springer Nature. Background: The identification of prognostic non-invasive biomarkers is a priority for cancer patients’ care. Circulating microRNA (miRNAs) have been described in numerous human malignancies as diagnostic, prognostic, and therapeutic cancer biomarkers. The aim of our study was to analyze the expression profile of a set of miRNAs, involved in the modulation of the glycolytic pathway, as prognostic factors in human head and neck squamous cell carcinomas (HNSCC). Methods: Serum samples of 54 patients with untreated HNSCC were obtained at the time of diagnosis. The prognostic value of circulating miR-26b, miR-124, miR-155 and miR-375 was evaluated towards disease-free survival. Results: We found that there were optimal miRNAs cut-off values for lower risk of recurrence in HNSCC patients. Kaplan–Meier curves showed that higher levels of miR-26b and lower levels of miR-155 were associated with better disease-free survival rates. In the multivariate analysis, patients with serum miR-26b > 0.062 and miR-155 < 0.159 presented more than 2.9 times lower risk of poor outcome. Conclusion: Our results suggest that two miRNAs that modulate the glycolytic pathway, miR-26b and miR-155, are independently associated with the risk of recurrence in patients with HNSCC. The overall results in this study supports the evidence that the glucose homeostasis may be a target to improve the outcomes for patients with HNSCC. Level of evidence: Individual retrospective cohort study (2b).
Thematic Areas: Otorhinolaryngology Odontología Medicine (miscellaneous) Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 09374477
Author's mail: franciscojavier.aviles@urv.cat carla.meler@urv.cat ximena.terra@urv.cat
Author identifier: 0000-0001-5560-8097 0000-0003-2263-4306 0000-0003-1043-5844
Record's date: 2024-10-12
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://link.springer.com/article/10.1007%2Fs00405-020-06240-z
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: European Archives Of Oto-Rhino-Laryngology. 278 (5): 1585-1594
APA: Xavier Aviles-Jurado, Francesc; Munoz, Carmen; Meler, Carla; Carles Flores, Joan; Guma, Josep; Benaiges, Ester; Mora, Josefina; Camacho, Mercedes; Leo (2021). Circulating microRNAs modulating glycolysis as non-invasive prognostic biomarkers of HNSCC. European Archives Of Oto-Rhino-Laryngology, 278(5), 1585-1594. DOI: 10.1007/s00405-020-06240-z
Article's DOI: 10.1007/s00405-020-06240-z
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications
Repositori URV