Author, as appears in the article.: Papandreou, Christopher; Bullo, Monica; Hernandez-Alonso, Pablo; Ruiz-Canela, Miguel; Li, Jun; Guasch-Ferre, Marta; Toledo, Estefania; Clish, Clary; Corella, Dolores; Estruch, Ramon; Ros, Emilio; Fito, Montserrat; Alonso-Gomez, Angel; Fiol, Miquel; Santos-Lozano, Jose M; Serra-Majem, Lluis; Liang, Liming; Martinez-Gonzalez, Miguel A; Hu, Frank B; Salas-Salvado, Jordi
Department: Bioquímica i Biotecnologia
URV's Author/s: Bulló Bonet, Mònica / Salas Salvadó, Jorge
Keywords: Trimethylamine-n-oxide Predimed Heart failure Choline metabolism Atrial fibrillation
Abstract: © American Association for Clinical Chemistry 2020. All rights reserved. For permissions, please email: journals.permissions@oup.com. BACKGROUND: Few studies have examined the associations of trimethylamine-N-oxide (TMAO) and its precursors (choline, betaine, dimethylglycine, and L-carnitine) with the risk of atrial fibrillation (AF) and heart failure (HF). This study sought to investigate these associations. METHODS: Prospective associations of these metabolites with incident AF and HF were examined among participants at high cardiovascular risk in the PREDIMED study (PREvención con DIeta MEDiterránea) after follow-up for about 10 years. Two nested case-control studies were conducted, including 509 AF incident cases matched to 618 controls and 326 HF incident cases matched to 426 controls. Plasma levels of TMAO and its precursors were semi-quantitatively profiled with liquid chromatography tandem mass spectrometry. Odds ratios were estimated with multivariable conditional logistic regression models. RESULTS: After adjustment for classical risk factors and accounting for multiple testing, participants in the highest quartile vs. the lowest quartile of baseline choline and betaine levels had a higher risk of AF [OR (95% CI): 1.85 (1.30-2.63) and 1.57 (1.09-2.24), respectively]. The corresponding OR for AF for extreme quartiles of dimethylglycine was 1.39 (0.99-1.96). One SD increase in log-transformed dimethylglycine was positively associated with AF risk (OR, 1.17; 1.03-1.33). The corresponding ORs for HF for extreme quartiles of choline, betaine, and dimethylglycine were 2.51 (1.57-4.03), 1.65 (1.00-2.71) and 1.65 (1.04-2.61), respectively. TMAO and L-carnitine levels were not associated with AF or HF. CONCLUSIONS: Our findings support the role of the choline metabolic pathway in the pathogenesis of AF and HF.
Thematic Areas: Odontología Medicine (miscellaneous) Medicine (all) Medicina iii Medicina ii Medicina i Medical laboratory technology General medicine Farmacia Clinical biochemistry Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología Biochemistry (medical)
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: monica.bullo@urv.cat jordi.salas@urv.cat
Author identifier: 0000-0002-0218-7046 0000-0003-2700-7459
Record's date: 2024-10-12
Papper version: info:eu-repo/semantics/submittedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Clinical Chemistry. 67 (1): 288-297
APA: Papandreou, Christopher; Bullo, Monica; Hernandez-Alonso, Pablo; Ruiz-Canela, Miguel; Li, Jun; Guasch-Ferre, Marta; Toledo, Estefania; Clish, Clary; C (2021). Choline Metabolism and Risk of Atrial Fibrillation and Heart Failure in the PREDIMED Study. Clinical Chemistry, 67(1), 288-297. DOI: 10.1093/clinchem/hvaa224
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications
Repositori URV