Author, as appears in the article.: Landmesser, Ulf; Pirillo, Angela; Farnier, Michel; Jukema, J. Wouter; Laufs, Ulrich; Mach, Francois; Masana, Luis; Pedersen, Terje R.; Schiele, Francois; Steg, Gabriel; Tubaro, Marco; Zaman, Azfar; Zamorano, Pepe; Catapano, Alberico L.;

Department: Medicina i Cirurgia

URV's Author/s: Masana Marín, Luis

Keywords: Statins Low-density lipoprotein cholesterol Lipid-lowering therapies Guidelines Acute coronary syndrome

Abstract: Background and aims: Post-acute coronary syndrome (ACS) patients are at very high risk for recurrent events and mortality, despite the availability of effective pharmacological approaches. Aim of this survey was to evaluate the compliance to ESC/EAS guidelines during the management of ACS patients and the effectiveness of secondary prevention in seven European countries. Methods: By means of an online questionnaire, data on 2775 ACS patients (either acute case or follow-up patients) were collected, including data on lipid profile, medications, follow-up visit planning, screening for familial hypercholesterolemia. Results: Lipid profiles were obtained for 91% of ACS patients in the acute phase, mostly within the first day of hospitalization (73%). During hospitalization, 93% of the patients received a lipid-lowering treatment; at discharge, only 66% of the patients received a high intensity statin therapy. At the first follow-up, most of the patients (77.6%) had LDL-C 70 mg/dL; among them, 41% had no change in their lipid-lowering therapies. Similar data were obtained during the second follow-up visit. The analysis of a subgroup of patients with at least 2 follow-up visits and known LDL-C levels showed that the percentage of patients at goal increased from 9% to 32%, and patients with LDL-C <100 mg/dL raised from 23% to 72%. Among acute cases, 44 were admitted with a diagnosis of familial hypercholesterolemia (FH); only 18% of the remaining patients were screened for FH. Conclusions: Contemporary lipid management of very high CV risk patients is sub-optimal despite available treatments. Greater efforts are warranted to optimize cardiovascular prevention. (c) 2021 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Thematic Areas: Peripheral vascular disease Medicine (miscellaneous) Medicina iii Medicina i Internal medicine Farmacia Ciências biológicas iii Cardiology and cardiovascular medicine Biotecnología

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: luis.masana@urv.cat

Author identifier: 0000-0002-0789-4954

Record's date: 2023-02-19

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.sciencedirect.com/science/article/pii/S1567568821000118?via%3Dihub

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Atherosclerosis Supplements. 42 E49-E58

APA: Landmesser, Ulf; Pirillo, Angela; Farnier, Michel; Jukema, J. Wouter; Laufs, Ulrich; Mach, Francois; Masana, Luis; Pedersen, Terje R.; Schiele, Franco (2020). Lipid-lowering therapy and low-density lipoprotein cholesterol goal achievement in patients with acute coronary syndromes: The ACS patient pathway project. Atherosclerosis Supplements, 42(), E49-E58. DOI: 10.1016/j.atherosclerosissup.2021.01.009

Article's DOI: 10.1016/j.atherosclerosissup.2021.01.009

Entity: Universitat Rovira i Virgili

Journal publication year: 2020

Publication Type: Journal Publications