Author, as appears in the article.: Watts, Gerald F.; Catapano, Alberico L.; Masana, Luis; Zambon, Alberto; Pirillo, Angela; Tokgozoglu, Lale;

Department: Medicina i Cirurgia

URV's Author/s: Masana Marín, Luis

Keywords: Hypercholesterolemia High risk patients Cardiovascular disease

Abstract: The widespread use of statins has largely improved the treatment of hypercholesterolemia, but many patients still fail to achieve the LDL-C targets recommended by guidelines. Furthermore, some patients continue to present a very high cardiovascular (CV) risk or even an extreme risk despite being well treated, mainly due to the presence of co-morbidities such as diabetes or peripheral artery disease, which significantly increase their global CV risk. For these very high CV risk patients, the most recent European guidelines have reviewed the LDL-C goals and recommend an LDL-C reduction of at least 50% and a goal of <55 mg/dL or even <40 mg/dL. Recent clinical trials have shown that patient stratification based on the presence or absence of atherothrombotic risk factors may represent a valuable tool to identify patients at extremely high CV risk who may benefit more from an aggressive LDL-C-lowering approach. In these patients it may be appropriate to aim for the lowest LDL-C level, independently of recommended goals, with all the available pharmacological approaches. (c) 2021 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Thematic Areas: Peripheral vascular disease Medicine (miscellaneous) Medicina iii Medicina i Internal medicine Farmacia Ciências biológicas iii Cardiology and cardiovascular medicine Biotecnología

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: luis.masana@urv.cat

Author identifier: 0000-0002-0789-4954

Record's date: 2023-02-19

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.sciencedirect.com/science/article/pii/S1567568821000088?via%3Dihub

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Atherosclerosis Supplements. 42 E30-E34

APA: Watts, Gerald F.; Catapano, Alberico L.; Masana, Luis; Zambon, Alberto; Pirillo, Angela; Tokgozoglu, Lale; (2020). Hypercholesterolemia and cardiovascular disease: Focus on high cardiovascular risk patients. Atherosclerosis Supplements, 42(), E30-E34. DOI: 10.1016/j.atherosclerosissup.2021.01.006

Article's DOI: 10.1016/j.atherosclerosissup.2021.01.006

Entity: Universitat Rovira i Virgili

Journal publication year: 2020

Publication Type: Journal Publications