Articles producció científica> Medicina i Cirurgia

Hypercholesterolemia and cardiovascular disease: Focus on high cardiovascular risk patients

  • Identification data

    Identifier: imarina:9162447
    Authors:
    Watts, Gerald F.Catapano, Alberico L.Masana, LuisZambon, AlbertoPirillo, AngelaTokgozoglu, Lale
    Abstract:
    The widespread use of statins has largely improved the treatment of hypercholesterolemia, but many patients still fail to achieve the LDL-C targets recommended by guidelines. Furthermore, some patients continue to present a very high cardiovascular (CV) risk or even an extreme risk despite being well treated, mainly due to the presence of co-morbidities such as diabetes or peripheral artery disease, which significantly increase their global CV risk. For these very high CV risk patients, the most recent European guidelines have reviewed the LDL-C goals and recommend an LDL-C reduction of at least 50% and a goal of <55 mg/dL or even <40 mg/dL. Recent clinical trials have shown that patient stratification based on the presence or absence of atherothrombotic risk factors may represent a valuable tool to identify patients at extremely high CV risk who may benefit more from an aggressive LDL-C-lowering approach. In these patients it may be appropriate to aim for the lowest LDL-C level, independently of recommended goals, with all the available pharmacological approaches. (c) 2021 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
  • Others:

    Author, as appears in the article.: Watts, Gerald F.; Catapano, Alberico L.; Masana, Luis; Zambon, Alberto; Pirillo, Angela; Tokgozoglu, Lale;
    Department: Medicina i Cirurgia
    URV's Author/s: Masana Marín, Luis
    Keywords: Hypercholesterolemia High risk patients Cardiovascular disease
    Abstract: The widespread use of statins has largely improved the treatment of hypercholesterolemia, but many patients still fail to achieve the LDL-C targets recommended by guidelines. Furthermore, some patients continue to present a very high cardiovascular (CV) risk or even an extreme risk despite being well treated, mainly due to the presence of co-morbidities such as diabetes or peripheral artery disease, which significantly increase their global CV risk. For these very high CV risk patients, the most recent European guidelines have reviewed the LDL-C goals and recommend an LDL-C reduction of at least 50% and a goal of <55 mg/dL or even <40 mg/dL. Recent clinical trials have shown that patient stratification based on the presence or absence of atherothrombotic risk factors may represent a valuable tool to identify patients at extremely high CV risk who may benefit more from an aggressive LDL-C-lowering approach. In these patients it may be appropriate to aim for the lowest LDL-C level, independently of recommended goals, with all the available pharmacological approaches. (c) 2021 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
    Thematic Areas: Peripheral vascular disease Medicine (miscellaneous) Medicina iii Medicina i Internal medicine Farmacia Ciências biológicas iii Cardiology and cardiovascular medicine Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: luis.masana@urv.cat
    Author identifier: 0000-0002-0789-4954
    Record's date: 2023-02-19
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/pii/S1567568821000088?via%3Dihub
    Papper original source: Atherosclerosis Supplements. 42 E30-E34
    APA: Watts, Gerald F.; Catapano, Alberico L.; Masana, Luis; Zambon, Alberto; Pirillo, Angela; Tokgozoglu, Lale; (2020). Hypercholesterolemia and cardiovascular disease: Focus on high cardiovascular risk patients. Atherosclerosis Supplements, 42(), E30-E34. DOI: 10.1016/j.atherosclerosissup.2021.01.006
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1016/j.atherosclerosissup.2021.01.006
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2020
    Publication Type: Journal Publications
  • Keywords:

    Cardiology and Cardiovascular Medicine,Internal Medicine,Medicine (Miscellaneous),Peripheral Vascular Disease
    Hypercholesterolemia
    High risk patients
    Cardiovascular disease
    Peripheral vascular disease
    Medicine (miscellaneous)
    Medicina iii
    Medicina i
    Internal medicine
    Farmacia
    Ciências biológicas iii
    Cardiology and cardiovascular medicine
    Biotecnología
  • Documents:

  • Cerca a google

    Search to google scholar