Author, as appears in the article.: Hernaez, Alvaro; Lassale, Camille; Castro-Barquero, Sara; Ros, Emilio; Tresserra-Rimbau, Anna; Castaner, Olga; Pinto, Xavier; Vazquez-Ruiz, Zenaida; Sorli, Jose, V; Salas-Salvado, Jordi; Lapetra, Jose; Gomez-Gracia, Enrique; Alonso-Gomez, Angel M.; Fiol, Miquel; Serra-Majem, Lluis; Sacanella, Emilio; Razquin, Cristina; Corella, Dolores; Guasch-Ferre, Marta; Cofan, Montserrat; Estruch, Ramon;

Department: Bioquímica i Biotecnologia

URV's Author/s: Salas Salvadó, Jorge

Keywords: Thrombocytosis Thrombocytopenia Smoking habit Randomized controlled trial Proportional hazards models Proportional hazards model Procedures Prevention Platelet count Physical activity Nut Normal value Never smoker Mortality risk Mortality Mediterranean diet Male Major clinical study Leukocyte count Iron Incidence Hypertriglyceridemia Hypertension Hypercholesterolemia Humans Human cell Human Heart disease risk factors Follow up Folic acid Female Extra virgin olive oil Ex-smoker Disease association Diet, mediterranean Diet Diabetes mellitus Current smoker Controlled study Cardiovascular risk Body mass Article Antithrombocytic agent All cause mortality Alcohol Aged Adverse event Adult

Abstract: There is little information on the dietary modulation of thrombosis-related risk factors such as platelet count. We aimed to assess the effects of Mediterranean diet (MedDiet) on platelet count and related outcomes in an older population at high cardiovascular risk. In participants of the PREDIMED (PREvencion con DIeta MEDiterranea) study, we assessed whether an intervention with a MedDiet enriched with extra-virgin olive oil or nuts, relative to a low-fat control diet, modulated platelet count (n = 4189), the risk of developing thrombocytosis and thrombocytopenia (n = 3086), and the association between these alterations and all-cause mortality (median follow-up time: 3.0 years). Although platelet count increased over time (+0.98 center dot 10(9) units/L center dot year [95% confidence interval: 0.12; 1.84]), MedDiet interventions moderated this increase, particularly in individuals with near-high baseline count (both MedDiets combined: -3.20 center dot 10(9) units/L center dot year [-5.81; -0.59]). Thrombocytopenia incidence was lower in the MedDiet interventions (incidence rates: 2.23% in control diet, 0.91% in MedDiets combined; hazard ratio: 0.44 [0.23; 0.83]). Finally, thrombocytopenia was associated with a higher risk of all-cause mortality (hazard ratio: 4.71 [2.69; 8.24]), but this relationship was attenuated in those allocated to MedDiet (p-interaction = 0.018). In brief, MedDiet maintained platelet counts within a healthy range and attenuated platelet-related mortality in older adults at high cardiovascular risk.

Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: jordi.salas@urv.cat

Author identifier: 0000-0003-2700-7459

Record's date: 2023-02-19

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.mdpi.com/2072-6643/13/2/559

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Nutrients. 13 (2): 1-13

APA: Hernaez, Alvaro; Lassale, Camille; Castro-Barquero, Sara; Ros, Emilio; Tresserra-Rimbau, Anna; Castaner, Olga; Pinto, Xavier; Vazquez-Ruiz, Zenaida; S (2021). Mediterranean Diet Maintained Platelet Count within a Healthy Range and Decreased Thrombocytopenia-Related Mortality Risk: A Randomized Controlled Trial. Nutrients, 13(2), 1-13. DOI: 10.3390/nu13020559

Article's DOI: 10.3390/nu13020559

Entity: Universitat Rovira i Virgili

Journal publication year: 2021

Publication Type: Journal Publications