Articles producció científica> Bioquímica i Biotecnologia

Mediterranean Diet Maintained Platelet Count within a Healthy Range and Decreased Thrombocytopenia-Related Mortality Risk: A Randomized Controlled Trial

  • Identification data

    Identifier: imarina:9172960
    Authors:
    Hernaez, AlvaroLassale, CamilleCastro-Barquero, SaraRos, EmilioTresserra-Rimbau, AnnaCastaner, OlgaPinto, XavierVazquez-Ruiz, ZenaidaSorli, Jose, VSalas-Salvado, JordiLapetra, JoseGomez-Gracia, EnriqueAlonso-Gomez, Angel M.Fiol, MiquelSerra-Majem, LluisSacanella, EmilioRazquin, CristinaCorella, DoloresGuasch-Ferre, MartaCofan, MontserratEstruch, Ramon
    Abstract:
    There is little information on the dietary modulation of thrombosis-related risk factors such as platelet count. We aimed to assess the effects of Mediterranean diet (MedDiet) on platelet count and related outcomes in an older population at high cardiovascular risk. In participants of the PREDIMED (PREvencion con DIeta MEDiterranea) study, we assessed whether an intervention with a MedDiet enriched with extra-virgin olive oil or nuts, relative to a low-fat control diet, modulated platelet count (n = 4189), the risk of developing thrombocytosis and thrombocytopenia (n = 3086), and the association between these alterations and all-cause mortality (median follow-up time: 3.0 years). Although platelet count increased over time (+0.98 center dot 10(9) units/L center dot year [95% confidence interval: 0.12; 1.84]), MedDiet interventions moderated this increase, particularly in individuals with near-high baseline count (both MedDiets combined: -3.20 center dot 10(9) units/L center dot year [-5.81; -0.59]). Thrombocytopenia incidence was lower in the MedDiet interventions (incidence rates: 2.23% in control diet, 0.91% in MedDiets combined; hazard ratio: 0.44 [0.23; 0.83]). Finally, thrombocytopenia was associated with a higher risk of all-cause mortality (hazard ratio: 4.71 [2.69; 8.24]), but this relationship was attenuated in those allocated to MedDiet (p-interaction = 0.018). In brief, MedDiet maintained platelet counts within a healthy range and attenuated platelet-related mortality in older adults at high cardiovascular risk.
  • Others:

    Author, as appears in the article.: Hernaez, Alvaro; Lassale, Camille; Castro-Barquero, Sara; Ros, Emilio; Tresserra-Rimbau, Anna; Castaner, Olga; Pinto, Xavier; Vazquez-Ruiz, Zenaida; Sorli, Jose, V; Salas-Salvado, Jordi; Lapetra, Jose; Gomez-Gracia, Enrique; Alonso-Gomez, Angel M.; Fiol, Miquel; Serra-Majem, Lluis; Sacanella, Emilio; Razquin, Cristina; Corella, Dolores; Guasch-Ferre, Marta; Cofan, Montserrat; Estruch, Ramon;
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Salas Salvadó, Jorge
    Keywords: Thrombocytosis Thrombocytopenia Smoking habit Randomized controlled trial Proportional hazards models Proportional hazards model Procedures Prevention Platelet count Physical activity Nut Normal value Never smoker Mortality risk Mortality Mediterranean diet Male Major clinical study Leukocyte count Iron Incidence Hypertriglyceridemia Hypertension Hypercholesterolemia Humans Human cell Human Heart disease risk factors Follow up Folic acid Female Extra virgin olive oil Ex-smoker Disease association Diet, mediterranean Diet Diabetes mellitus Current smoker Controlled study Cardiovascular risk Body mass Article Antithrombocytic agent All cause mortality Alcohol Aged Adverse event Adult
    Abstract: There is little information on the dietary modulation of thrombosis-related risk factors such as platelet count. We aimed to assess the effects of Mediterranean diet (MedDiet) on platelet count and related outcomes in an older population at high cardiovascular risk. In participants of the PREDIMED (PREvencion con DIeta MEDiterranea) study, we assessed whether an intervention with a MedDiet enriched with extra-virgin olive oil or nuts, relative to a low-fat control diet, modulated platelet count (n = 4189), the risk of developing thrombocytosis and thrombocytopenia (n = 3086), and the association between these alterations and all-cause mortality (median follow-up time: 3.0 years). Although platelet count increased over time (+0.98 center dot 10(9) units/L center dot year [95% confidence interval: 0.12; 1.84]), MedDiet interventions moderated this increase, particularly in individuals with near-high baseline count (both MedDiets combined: -3.20 center dot 10(9) units/L center dot year [-5.81; -0.59]). Thrombocytopenia incidence was lower in the MedDiet interventions (incidence rates: 2.23% in control diet, 0.91% in MedDiets combined; hazard ratio: 0.44 [0.23; 0.83]). Finally, thrombocytopenia was associated with a higher risk of all-cause mortality (hazard ratio: 4.71 [2.69; 8.24]), but this relationship was attenuated in those allocated to MedDiet (p-interaction = 0.018). In brief, MedDiet maintained platelet counts within a healthy range and attenuated platelet-related mortality in older adults at high cardiovascular risk.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: jordi.salas@urv.cat
    Author identifier: 0000-0003-2700-7459
    Record's date: 2024-07-27
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/2072-6643/13/2/559
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Nutrients. 13 (2): 1-13
    APA: Hernaez, Alvaro; Lassale, Camille; Castro-Barquero, Sara; Ros, Emilio; Tresserra-Rimbau, Anna; Castaner, Olga; Pinto, Xavier; Vazquez-Ruiz, Zenaida; S (2021). Mediterranean Diet Maintained Platelet Count within a Healthy Range and Decreased Thrombocytopenia-Related Mortality Risk: A Randomized Controlled Trial. Nutrients, 13(2), 1-13. DOI: 10.3390/nu13020559
    Article's DOI: 10.3390/nu13020559
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2021
    Publication Type: Journal Publications
  • Keywords:

    Food Science,Nutrition & Dietetics,Nutrition and Dietetics
    Thrombocytosis
    Thrombocytopenia
    Smoking habit
    Randomized controlled trial
    Proportional hazards models
    Proportional hazards model
    Procedures
    Prevention
    Platelet count
    Physical activity
    Nut
    Normal value
    Never smoker
    Mortality risk
    Mortality
    Mediterranean diet
    Male
    Major clinical study
    Leukocyte count
    Iron
    Incidence
    Hypertriglyceridemia
    Hypertension
    Hypercholesterolemia
    Humans
    Human cell
    Human
    Heart disease risk factors
    Follow up
    Folic acid
    Female
    Extra virgin olive oil
    Ex-smoker
    Disease association
    Diet, mediterranean
    Diet
    Diabetes mellitus
    Current smoker
    Controlled study
    Cardiovascular risk
    Body mass
    Article
    Antithrombocytic agent
    All cause mortality
    Alcohol
    Aged
    Adverse event
    Adult
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Planejamento urbano e regional / demografia
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science
    Farmacia
    Engenharias iv
    Engenharias ii
    Enfermagem
    Educação física
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
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