Author, as appears in the article.: Hernaez, Alvaro; Lassale, Camille; Castro-Barquero, Sara; Ros, Emilio; Tresserra-Rimbau, Anna; Castaner, Olga; Pinto, Xavier; Vazquez-Ruiz, Zenaida; Sorli, Jose, V; Salas-Salvado, Jordi; Lapetra, Jose; Gomez-Gracia, Enrique; Alonso-Gomez, Angel M; Fiol, Miquel; Serra-Majem, Lluis; Sacanella, Emilio; Razquin, Cristina; Corella, Dolores; Guasch-Ferre, Marta; Cofan, Montserrat; Estruch, Ramon
Department: Bioquímica i Biotecnologia
URV's Author/s: Salas Salvadó, Jorge
Keywords: Thrombocytosis; Thrombocytopenia; Smoking habit; Randomized controlled trial; Proportional hazards models; Proportional hazards model; Procedures; Prevention; Platelet count; Physical activity; Nut; Normal value; Never smoker; Mortality risk; Mortality; Mediterranean diet; Male; Major clinical study; Leukocyte count; Iron; Incidence; Hypertriglyceridemia; Hypertension; Hypercholesterolemia; Humans; Human cell; Human; Heart disease risk factors; Follow up; Folic acid; Female; Extra virgin olive oil; Ex-smoker; Disease association; Diet, mediterranean; Diet; Diabetes mellitus; Current smoker; Controlled study; Cardiovascular risk; Body mass; Article; Antithrombocytic agent; All cause mortality; Alcohol; Aged; Adverse event; Adult
Abstract: There is little information on the dietary modulation of thrombosis-related risk factors such as platelet count. We aimed to assess the effects of Mediterranean diet (MedDiet) on platelet count and related outcomes in an older population at high cardiovascular risk. In participants of the PREDIMED (PREvencion con DIeta MEDiterranea) study, we assessed whether an intervention with a MedDiet enriched with extra-virgin olive oil or nuts, relative to a low-fat control diet, modulated platelet count (n = 4189), the risk of developing thrombocytosis and thrombocytopenia (n = 3086), and the association between these alterations and all-cause mortality (median follow-up time: 3.0 years). Although platelet count increased over time (+0.98 center dot 10(9) units/L center dot year [95% confidence interval: 0.12; 1.84]), MedDiet interventions moderated this increase, particularly in individuals with near-high baseline count (both MedDiets combined: -3.20 center dot 10(9) units/L center dot year [-5.81; -0.59]). Thrombocytopenia incidence was lower in the MedDiet interventions (incidence rates: 2.23% in control diet, 0.91% in MedDiets combined; hazard ratio: 0.44 [0.23; 0.83]). Finally, thrombocytopenia was associated with a higher risk of all-cause mortality (hazard ratio: 4.71 [2.69; 8.24]), but this relationship was attenuated in those allocated to MedDiet (p-interaction = 0.018). In brief, MedDiet maintained platelet counts within a healthy range and attenuated platelet-related mortality in older adults at high cardiovascular risk.
Thematic Areas: Zootecnia / recursos pesqueiros; Saúde coletiva; Química; Psicología; Planejamento urbano e regional / demografia; Nutrition and dietetics; Nutrition & dietetics; Nutrição; Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Interdisciplinar; Food science; Farmacia; Engenharias iv; Engenharias ii; Enfermagem; Educação física; Economia; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências agrárias i; Ciência de alimentos; Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: jordi.salas@urv.cat
Record's date: 2025-02-18
Paper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2072-6643/13/2/559
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Nutrients. 13 (2): 1-13
APA: Hernaez, Alvaro; Lassale, Camille; Castro-Barquero, Sara; Ros, Emilio; Tresserra-Rimbau, Anna; Castaner, Olga; Pinto, Xavier; Vazquez-Ruiz, Zenaida; S (2021). Mediterranean Diet Maintained Platelet Count within a Healthy Range and Decreased Thrombocytopenia-Related Mortality Risk: A Randomized Controlled Trial. Nutrients, 13(2), 1-13. DOI: 10.3390/nu13020559
Article's DOI: 10.3390/nu13020559
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications
Repositori URV