Author, as appears in the article.: Bertran, Laia; Portillo-Carrasquer, Marta; Aguilar, Carmen; Antonio Porras, Jose; Riesco, David; Martinez, Salome; Vives, Margarita; Sabench, Fatima; Gonzalez, Eva; Del Castillo, Daniel; Richart, Cristobal; Auguet, Teresa
Department: Medicina i Cirurgia
URV's Author/s: Aguilar Crespillo, Carmen Isabel / Auguet Quintillà, Maria Teresa / Bertran Ramos, Laia / Del Castillo Déjardin, Daniel / GONZÁLEZ GARCÍA, ELENA / Martínez González, María Salomé / Porras Ledantes, Jose Antonio / Richart Jurado, Cristobal Manuel / Riesco Acevedo, David Gerardo / Sabench Pereferrer, Fàtima / VIVES GARCIA, MARIA
Keywords: Wnt5a protein, human Wnt-5a protein Sfrp5 protein, human Sfrp5 Rna, messenger Obesity, morbid Noncanonical wnt pathway Nonalcoholic fatty liver disease Non-alcoholic fatty liver disease Map kinase kinase 4 Liver Inflammation mediators Inflammation Immunohistochemistry Humans Disease susceptibility Body mass index Biomarkers Adipokines Adaptor proteins, signal transducing wnt steatohepatitis noncanonical wnt pathway nonalcoholic fatty liver disease liver inflammation epidemiology
Abstract: Secreted frizzled-related protein 5 (SFRP5), an antagonist of the noncanonical WNT pathway, has a controversial role in liver disease. The aim of this study was to analyze the role of SFRP5 and the noncanonical WNT pathway in nonalcoholic fatty liver disease (NAFLD). Plasma SFRP5 levels were determined by ELISA in women with normal weight (NW; n = 20) and morbid obesity (MO; n = 69). Women with MO were subclassified according to hepatic histology into normal liver (NL; n = 28), NAFLD (n = 41) (simple steatosis (SS; n = 24), and nonalcoholic steatohepatitis (NASH; n = 17)). We used RT-qPCR to evaluate the hepatic mRNA expression of SFRP5, WNT5A, and JNK in women with MO. SFRP5 levels were lower in NW than in MO patients who underwent a very low-calorie diet before surgery. Hepatic SFRP5 mRNA expression was higher in SS than in NL or NASH; additionally, patients with hepatic inflammation or ballooning presented lower SFRP5 abundance. WNT5A and JNK expression was enhanced in NAFLD compared with NL. In conclusion, circulating SFRP5 levels depend on the diet, and hepatic SFRP5 seems to have a protective role in the first steps of NAFLD; however, SFRP5 could be deregulated in an advanced stage while WNT5A and JNK are activated, promoting liver damage.
Thematic Areas: Zootecnia / recursos pesqueiros Spectroscopy Saúde coletiva Química Psicología Physical and theoretical chemistry Organic chemistry Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Inorganic chemistry Geociências Farmacia Engenharias iv Engenharias ii Engenharias i Educação física Computer science applications Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, multidisciplinary Catalysis Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: davidgerardo.riesco@urv.cat joseantonio.porras@urv.cat mariasalome.martinez@urv.cat danieldel.castillo@urv.cat laia.bertranr@estudiants.urv.cat laia.bertranr@estudiants.urv.cat fatima.sabench@urv.cat carmenisabel.aguilar@urv.cat carmenisabel.aguilar@urv.cat mariateresa.auguet@urv.cat
Author identifier: 0000-0001-6418-1822 0000-0001-6185-2889 0000-0003-0456-3102 0000-0001-7024-7824 0000-0001-9052-1368 0000-0001-9052-1368 0000-0002-9262-8756 0000-0002-4440-562X 0000-0002-4440-562X 0000-0003-0396-6428
Record's date: 2024-09-28
Journal volume: 22
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/1422-0067/22/13/6895
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: International Journal Of Molecular Sciences. 22 (13): 6895-
APA: Bertran, Laia; Portillo-Carrasquer, Marta; Aguilar, Carmen; Antonio Porras, Jose; Riesco, David; Martinez, Salome; Vives, Margarita; Sabench, Fatima; (2021). Deregulation of secreted frizzled-related protein 5 in nonalcoholic fatty liver disease associated with obesity. International Journal Of Molecular Sciences, 22(13), 6895-. DOI: 10.3390/ijms22136895
Article's DOI: 10.3390/ijms22136895
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications
Repositori URV