Author, as appears in the article.: Calvo, Enrique; Keiran, Noelia; Nunez-Roa, Catalina; Maymo-Masip, Elsa; Ejarque, Miriam; Sabadell-Basallote, Joan; Del Mar Rodriguez-Pena, Maria; Ceperuelo-Mallafre, Victoria; Seco, Jesus; Benaiges, Ester; Michalopoulou, Theodora; Jorba, Rosa; Vendrell, Joan; Fernandez-Veledo, Sonia;

Department: Ciències Mèdiques Bàsiques

URV's Author/s: Benaiges Moragrega, Ester / Ceperuelo Mallafré, Maria Victoria / Fernandez Veledo, Sonia / Jorba Martin, Rosa Maria / Keiran Fernandez, Noelia Elisabeth / Maymo Masip, Elsa / Sabadell I Basallote, Joan-Martí / VENDRELL FERRE, JOAN / Vendrell Ortega, Juan José

Keywords: White adipose tissue Weight gain Stem cells Stem cell Pheochromocytoma Patient Pathology Obesity Middle aged Mice, inbred c57bl Metabolism Male Lipid metabolism Insulin-resistance Inflammation Humans Human Glucose-homeostasis Glucose Genetics Gene expression regulation Free fatty-acids Female Diet C57bl mouse Bone-marrow Body weight gain Biomarkers Biological marker Animals Animal Adrenal tumor Adrenal gland neoplasms Adipose tissue, white

Abstract: Adipose-derived mesenchymal stem cells (ASCs) are a promising option for the treatment of obesity and its metabolic co-morbidities. Despite the recent identification of brown adipose tissue (BAT) as a potential target in the management of obesity, the use of ASCs isolated from BAT as a therapy for patients with obesity has not yet been explored. Metabolic activation of BAT has been shown to have not only thermogenic effects, but it also triggers the secretion of factors that confer protection against obesity. Herein, we isolated and characterized ASCs from the visceral adipose tissue surrounding a pheochromocytoma (IB-hASCs), a model of inducible BAT in humans. We then compared the anti-obesity properties of IB-hASCs and human ASCs isolated from visceral white adipose tissue (W-hASCs) in a murine model of diet-induced obesity. We found that both ASC therapies mitigated the metabolic abnormalities of obesity to a similar extent, including reducing weight gain and improving glucose tolerance. However, infusion of IB-hASCs was superior to W-hASCs in suppressing lipogenic and inflammatory markers, as well as preserving insulin secretion. Our findings provide evidence for the metabolic benefits of visceral ASC infusion and support further studies on IB-hASCs as a therapeutic option for obesity-related comorbidities.

Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Letras / linguística Interdisciplinar Geografía Geociências Farmacia Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: sonia.fernandez@urv.cat elsa.maymo@urv.cat rosamaria.jorba@urv.cat victoria.ceperuelo@urv.cat juanjose.vendrell@urv.cat ester.benaiges@urv.cat joanmarti.sabadell@estudiants.urv.cat

Author identifier: 0000-0003-2906-3788 0000-0002-9133-3120 0000-0003-3307-4340 0000-0002-4460-9761 0000-0002-6994-6115

Record's date: 2023-10-07

Journal volume: 11

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.nature.com/articles/s41598-021-93224-6

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Scientific Reports. 11 (1): 13923-

APA: Calvo, Enrique; Keiran, Noelia; Nunez-Roa, Catalina; Maymo-Masip, Elsa; Ejarque, Miriam; Sabadell-Basallote, Joan; Del Mar Rodriguez-Pena, Maria; Cepe (2021). Effects of stem cells from inducible brown adipose tissue on diet-induced obesity in mice. Scientific Reports, 11(1), 13923-. DOI: 10.1038/s41598-021-93224-6

Article's DOI: 10.1038/s41598-021-93224-6

Entity: Universitat Rovira i Virgili

Journal publication year: 2021

Publication Type: Journal Publications