Author, as appears in the article.: Gesteiro, Eva; Megia, Ana; Guadalupe-Grau, Amelia; Fernandez-Veledo, Sonia; Vendrell, Joan; Gonzalez-Gross, Marcela;

Department: Ciències Mèdiques Bàsiques

URV's Author/s: Fernandez Veledo, Sonia / Vendrell Ortega, Juan José

Keywords: Xanthophyll Waist hip ratio Waist circumference Vitamin-d Vitamin d Uric acid blood level Uric acid Type-2 diabetes-mellitus Tumor necrosis factor Triacylglycerol blood level Triacylglycerol Testosterone Terminology as topic Systolic blood pressure Systematic review Sodium blood level Sodium Sleep quality Sleep Sarcopenia Rosacea Risk score Risk factor Risk assessment Review Resistin Prognosis Predictive value of tests Predictive value Polycystic-ovary-syndrome Periodontitis Pathogenesis Oxidized low density lipoprotein antibody Osteocalcin Omega 3 fatty acid Obesity Normal-weight Nonalcoholic fatty liver Non insulin dependent diabetes mellitus Nomenclature Muscular strength Morphogenesis Microflora Metabolic syndrome x Metabolic syndrome components Metabolic syndrome Meta analysis Magnesium Low density lipoprotein cholesterol Leptin Interleukin 6 Interleukin 10 Indicators Hydrocortisone Humans High density lipoprotein cholesterol Heart-rate Health status indicators Health status indicator Glutamic acid Glucose Gamma glutamyltransferase Follow up Fitness Fibroblast growth factor 21 Ferritin Fatty liver-disease Fasting Early diagnosis Dose-response metaanalysis Diastolic blood pressure Data extraction Classification Cardiorespiratory fitness Cardiometabolic risk factors Cardiometabolic risk Cardiometabolic health risk C-reactive protein C reactive protein Body mass Blood Biomarkers Biological marker Bilirubin blood level Bilirubin Article Adiponectin Abdominal obesity Abdominal fat

Abstract: Aims: a) To analyze the relationship of known and emerging biomarkers/indicators for early risk identification of cardiometabolic health risk; b) to identify early risk markers to be used in both clinical and nonclinical settings; and c) to propose a definition of early risk identification in terms of pre-metabolic syndrome (PreMetSyn). Data synthesis: Pubmed/Medline, Web of Science, Embase, and Cochrane were searched for Systematic Reviews and Meta-analysis. Selected studies were evaluated, and relevant data were extracted and synthesized. Conclusions: Serum uric acid is a good predictive biomarker of metabolic syndrome (MetSyn) and has been associated with non-alcoholic liver fat disease (NAFLD) and type 2 diabetes. NAFLD emerges as an early risk indicator of PreMetSyn by itself. Muscle strength should also be included as an early risk marker of cardiometabolic health. High serum triglycerides and waist circumference confirm their predictive value regarding MetSyn. Indicators related to an inflammatory/proinflammatory status usually linked to MetSyn showed limited evidence as robust biomarkers for PreMetSyn. Authors suggest defining PreMetSyn related to cardiometabolic risk. It is also necessary to determine how close people are to the cut-off point of MetSyn components, including emerging indicators proposed by our review. Some biomarkers could be used as indicators of PreMetSyn, before any of the MetSyn components appear, allowing early health interventions to prevent its development. Defining a PreMetSyn status might consider both emerging indicators and those variables already included in the definition of MetSyn. New indicators should be considered to create a new risk score specifically meant for PreMetSyn. (c) 2021 The Authors. Published by Elsevier B.V. on behalf of The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

Thematic Areas: Serviço social Saúde coletiva Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Enfermagem Endocrinology, diabetes and metabolism Endocrinology & metabolism Educação física Ciências biológicas ii Ciências biológicas i Ciências ambientais Cardiology and cardiovascular medicine Cardiac & cardiovascular systems

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: sonia.fernandez@urv.cat juanjose.vendrell@urv.cat

Author identifier: 0000-0003-2906-3788 0000-0002-6994-6115

Record's date: 2023-02-19

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.nmcd-journal.com/article/S0939-4753(21)00245-3/fulltext

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Nutrition Metabolism And Cardiovascular Diseases. 31 (9): 2557-2574

APA: Gesteiro, Eva; Megia, Ana; Guadalupe-Grau, Amelia; Fernandez-Veledo, Sonia; Vendrell, Joan; Gonzalez-Gross, Marcela; (2021). Early identification of metabolic syndrome risk: A review of reviews and proposal for defining pre-metabolic syndrome status. Nutrition Metabolism And Cardiovascular Diseases, 31(9), 2557-2574. DOI: 10.1016/j.numecd.2021.05.022

Article's DOI: 10.1016/j.numecd.2021.05.022

Entity: Universitat Rovira i Virgili

Journal publication year: 2021

Publication Type: Journal Publications