Articles producció científica> Medicina i Cirurgia

Bempedoic acid. Mechanism of action and pharmacokinetic and pharmacodynamic properties

  • Identification data

    Identifier: imarina:9226474
    Authors:
    Marin, Lluis MasanaGil, Nuria Plana
    Abstract:
    Bempedoic acid acts by inhibiting adenosine triphosphate-citrate lyase (ACL) and consequently cholesterol biosynthesis, leading to increased expression of LDL receptors and increasing low-density lipoproteins (LDL-C) plasma clearence. It is a prodrug for oral administration with intracellular activation. It is activatedin liver cells and to a lesser extent in kidney cells, being absent in adipose tissue and muscle cells. Therefore, unlike statins, its potential myotoxic effect is very limited. It has recently been approved as a lipid-lowering drug in combination with diet, with statins, or with other lipid-lowering drugs in patients with hypercholesterolaemia, mixed dyslipidaemia, statin intolerance, or when these are contraindicated. The marketing of bempedoic acid implies, in clinical practice, having a new family of lipid-lowering drugs. (c) 2021 Sociedad Espanola de Arteriosclerosis. Published by Elsevier Espana, S.L.U. All rights reserved.
  • Others:

    Author, as appears in the article.: Marin, Lluis Masana; Gil, Nuria Plana;
    Department: Medicina i Cirurgia
    URV's Author/s: Masana Marín, Luis
    Keywords: Targets Low-density lipoprotein cholesterol Inhibitor atp citrate lyase Hyperlipidemia Bempedoic acid Atp-citrate lyase Atherosclerosis Activated protein-kinase
    Abstract: Bempedoic acid acts by inhibiting adenosine triphosphate-citrate lyase (ACL) and consequently cholesterol biosynthesis, leading to increased expression of LDL receptors and increasing low-density lipoproteins (LDL-C) plasma clearence. It is a prodrug for oral administration with intracellular activation. It is activatedin liver cells and to a lesser extent in kidney cells, being absent in adipose tissue and muscle cells. Therefore, unlike statins, its potential myotoxic effect is very limited. It has recently been approved as a lipid-lowering drug in combination with diet, with statins, or with other lipid-lowering drugs in patients with hypercholesterolaemia, mixed dyslipidaemia, statin intolerance, or when these are contraindicated. The marketing of bempedoic acid implies, in clinical practice, having a new family of lipid-lowering drugs. (c) 2021 Sociedad Espanola de Arteriosclerosis. Published by Elsevier Espana, S.L.U. All rights reserved.
    Thematic Areas: Pharmacology (medical) Peripheral vascular disease Medicina iii Medicina i Cardiology and cardiovascular medicine
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: luis.masana@urv.cat
    Author identifier: 0000-0002-0789-4954
    Record's date: 2024-07-27
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/pii/S0214916821000462?via%3Dihub
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Clinica E Investigacion En Arteriosclerosis. 33 53-57
    APA: Marin, Lluis Masana; Gil, Nuria Plana; (2021). Bempedoic acid. Mechanism of action and pharmacokinetic and pharmacodynamic properties. Clinica E Investigacion En Arteriosclerosis, 33(), 53-57. DOI: 10.1016/j.arteri.2021.02.012
    Article's DOI: 10.1016/j.arteri.2021.02.012
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2021
    Publication Type: Journal Publications
  • Keywords:

    Cardiology and Cardiovascular Medicine,Peripheral Vascular Disease,Pharmacology (Medical)
    Targets
    Low-density lipoprotein cholesterol
    Inhibitor atp citrate lyase
    Hyperlipidemia
    Bempedoic acid
    Atp-citrate lyase
    Atherosclerosis
    Activated protein-kinase
    Pharmacology (medical)
    Peripheral vascular disease
    Medicina iii
    Medicina i
    Cardiology and cardiovascular medicine
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