Author, as appears in the article.: Valls, Rosa M.; Pedret, Anna; Calderon-Perez, Lorena; Llaurado, Elisabet; Pla-Paga, Laura; Companys, Judit; Moragas, Ana; Martin-Lujan, Francisco; Ortega, Yolanda; Giralt, Montse; Rubio, Laura; Canela, Nuria; Puiggros, Francesc; Caimari, Antoni; Del Bas, Josep M.; Arola, Lluis; Sola, Rosa;

Department: Medicina i Cirurgia

URV's Author/s: Arola Ferrer, Luis Maria / Giralt Batista, Montserrat / Llauradó Ribé, Elisabet / Pedret Figuerola, Anna / Solà Alberich, Rosa Maria

Keywords: Ve-cadherin Reactive hyperemia Own phenolic-compounds Orange juice Junctions Inflammation Hesperidin Hesperetin Glucosyl hesperidin Endothelial function Elevated blood pressure Dysfunction Biomarkers Arterial stiffness

Abstract: In a randomized, parallel, double-blind, placebo-controlled trial, participants with elevated blood pressure and stage 1 hypertension (n = 159) received 500 mL/day of control drink, orange juice (OJ), or hesperidin-enriched OJ (EOJ) for 12-weeks, and their ischaemic reactive hyperemia (IRH) was assessed at baseline and after 4, 8, and 12-weeks. Two dose-response studies were nested within the sustained-consumption study: at baseline and after 12-weeks, a single dose of 500 mL was administered. All treatments increased postpandrial IRH, and a higher increase was obtained with EOJ. Moreover, hs-CRP and IL6 increased but not after EOJ. After 12 weeks of sustained consumption: IRH values after EOJ increased versus control group; EOJ treatment increased DSP and decreased IEX-1 gene expression in PBMCs; and IRH directly correlated to NO and inversely to MPO and IEX1. Thus, hesperidin in OJ improves human endothelial function, lower inflammatory status at systemic level and changes at transcriptomic level might account for the increased IRH observed.

Thematic Areas: Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Food science Farmacia Engenharias iii Engenharias ii Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: elisabet.llaurado@urv.cat anna.pedret@urv.cat lluis.arola@urv.cat rosa.sola@urv.cat montse.giralt@urv.cat

Author identifier: 0000-0002-7439-9531 0000-0002-5327-932X 0000-0003-2767-1974 0000-0002-8359-235X 0000-0002-7073-577X

Record's date: 2023-02-19

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.sciencedirect.com/science/article/pii/S1756464621002954

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Journal Of Functional Foods. 85

APA: Valls, Rosa M.; Pedret, Anna; Calderon-Perez, Lorena; Llaurado, Elisabet; Pla-Paga, Laura; Companys, Judit; Moragas, Ana; Martin-Lujan, Francisco; Ort (2021). Hesperidin in orange juice improves human endothelial function in subjects with elevated blood pressure and stage 1 hypertension: A randomized, controlled trial (Citrus study). Journal Of Functional Foods, 85(), -. DOI: 10.1016/j.jff.2021.104646

Article's DOI: 10.1016/j.jff.2021.104646

Entity: Universitat Rovira i Virgili

Journal publication year: 2021

Publication Type: Journal Publications