Articles producció científica> Medicina i Cirurgia

Hesperidin in orange juice improves human endothelial function in subjects with elevated blood pressure and stage 1 hypertension: A randomized, controlled trial (Citrus study)

  • Identification data

    Identifier: imarina:9226660
    Authors:
    Valls, Rosa M.Pedret, AnnaCalderon-Perez, LorenaLlaurado, ElisabetPla-Paga, LauraCompanys, JuditMoragas, AnaMartin-Lujan, FranciscoOrtega, YolandaGiralt, MontseRubio, LauraCanela, NuriaPuiggros, FrancescCaimari, AntoniDel Bas, Josep M.Arola, LluisSola, Rosa
    Abstract:
    In a randomized, parallel, double-blind, placebo-controlled trial, participants with elevated blood pressure and stage 1 hypertension (n = 159) received 500 mL/day of control drink, orange juice (OJ), or hesperidin-enriched OJ (EOJ) for 12-weeks, and their ischaemic reactive hyperemia (IRH) was assessed at baseline and after 4, 8, and 12-weeks. Two dose-response studies were nested within the sustained-consumption study: at baseline and after 12-weeks, a single dose of 500 mL was administered. All treatments increased postpandrial IRH, and a higher increase was obtained with EOJ. Moreover, hs-CRP and IL6 increased but not after EOJ. After 12 weeks of sustained consumption: IRH values after EOJ increased versus control group; EOJ treatment increased DSP and decreased IEX-1 gene expression in PBMCs; and IRH directly correlated to NO and inversely to MPO and IEX1. Thus, hesperidin in OJ improves human endothelial function, lower inflammatory status at systemic level and changes at transcriptomic level might account for the increased IRH observed.
  • Others:

    Author, as appears in the article.: Valls, Rosa M.; Pedret, Anna; Calderon-Perez, Lorena; Llaurado, Elisabet; Pla-Paga, Laura; Companys, Judit; Moragas, Ana; Martin-Lujan, Francisco; Ortega, Yolanda; Giralt, Montse; Rubio, Laura; Canela, Nuria; Puiggros, Francesc; Caimari, Antoni; Del Bas, Josep M.; Arola, Lluis; Sola, Rosa;
    Department: Medicina i Cirurgia
    URV's Author/s: Arola Fernández, Lluís / Arola Ferrer, Luis Maria / Calderon Pérez, Lorena / Companys Alemany, Judit / Del Bas Prior, José María / Giralt Batista, Montserrat / Llauradó Ribé, Elisabet / Moragas Fernández, Albert / Pedret Figuerola, Anna / PLA PAGA, LAURA / Puiggros Llavinés, Francesc / Solà Alberich, Rosa Maria / Valls Zamora, Rosa Maria
    Keywords: Ve-cadherin Reactive hyperemia Own phenolic-compounds Orange juice Junctions Inflammation Hesperidin Hesperetin Glucosyl hesperidin Endothelial function Elevated blood pressure Dysfunction Biomarkers Arterial stiffness
    Abstract: In a randomized, parallel, double-blind, placebo-controlled trial, participants with elevated blood pressure and stage 1 hypertension (n = 159) received 500 mL/day of control drink, orange juice (OJ), or hesperidin-enriched OJ (EOJ) for 12-weeks, and their ischaemic reactive hyperemia (IRH) was assessed at baseline and after 4, 8, and 12-weeks. Two dose-response studies were nested within the sustained-consumption study: at baseline and after 12-weeks, a single dose of 500 mL was administered. All treatments increased postpandrial IRH, and a higher increase was obtained with EOJ. Moreover, hs-CRP and IL6 increased but not after EOJ. After 12 weeks of sustained consumption: IRH values after EOJ increased versus control group; EOJ treatment increased DSP and decreased IEX-1 gene expression in PBMCs; and IRH directly correlated to NO and inversely to MPO and IEX1. Thus, hesperidin in OJ improves human endothelial function, lower inflammatory status at systemic level and changes at transcriptomic level might account for the increased IRH observed.
    Thematic Areas: Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Food science Farmacia Engenharias iii Engenharias ii Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: josepm.delbas@urv.cat francesc.puiggros@urv.cat lorena.calderon@urv.cat judit.companys@urv.cat anna.pedret@urv.cat albert.moragas@urv.cat elisabet.llaurado@urv.cat albert.moragas@urv.cat lluis.arola@estudiants.urv.cat lluis.arola@estudiants.urv.cat montse.giralt@urv.cat judit.companys@urv.cat judit.companys@urv.cat lorena.calderon@urv.cat rosamaria.valls@urv.cat rosa.sola@urv.cat lluis.arola@urv.cat
    Author identifier: 0000-0003-0766-0733 0000-0003-1485-0818 0000-0002-5327-932X 0000-0002-7439-9531 0000-0002-7073-577X 0000-0003-1485-0818 0000-0003-1485-0818 0000-0003-0766-0733 0000-0002-3351-0942 0000-0002-8359-235X 0000-0003-2767-1974
    Record's date: 2024-07-27
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/pii/S1756464621002954
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Journal Of Functional Foods. 85
    APA: Valls, Rosa M.; Pedret, Anna; Calderon-Perez, Lorena; Llaurado, Elisabet; Pla-Paga, Laura; Companys, Judit; Moragas, Ana; Martin-Lujan, Francisco; Ort (2021). Hesperidin in orange juice improves human endothelial function in subjects with elevated blood pressure and stage 1 hypertension: A randomized, controlled trial (Citrus study). Journal Of Functional Foods, 85(), -. DOI: 10.1016/j.jff.2021.104646
    Article's DOI: 10.1016/j.jff.2021.104646
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2021
    Publication Type: Journal Publications
  • Keywords:

    Food Science,Food Science & Technology,Medicine (Miscellaneous),Nutrition & Dietetics,Nutrition and Dietetics
    Ve-cadherin
    Reactive hyperemia
    Own phenolic-compounds
    Orange juice
    Junctions
    Inflammation
    Hesperidin
    Hesperetin
    Glucosyl hesperidin
    Endothelial function
    Elevated blood pressure
    Dysfunction
    Biomarkers
    Arterial stiffness
    Saúde coletiva
    Química
    Odontología
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Food science & technology
    Food science
    Farmacia
    Engenharias iii
    Engenharias ii
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
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