In vitro evaluation of aerosol delivery of aztreonam lysine (AZLI): an adult mechanical ventilation model

Identifier:  imarina:9230975

Handle: https://hdl.handle.net/20.500.11797/imarina9230975

Authors:  Rodriguez, Alejandro; Cabrera, Maria; Reyes, Luis F; Bodi, Maria; Trefler, Sandra; Canadell, Laura; Barahona, Diego; Ehrmann, Stepham; Martin-Loeches, Ignacio; Restrepo, Marcos I; Vecellio, Laurent

Abstract:
The delivery profile of Aztreonam lysine (AZLI) during mechanical ventilation (MV) is unknown. We evaluated the amount of AZLI drug delivered using an in vitro model of adult MV. An adult lung model designed to mimic current clinical practice was used. Both nebulizers were placed before a Y-piece and 4 settings were tested: A) Aeroneb solo® [AS] with a t-piece; B) AS with the spacer; C) M-Neb® [MN] with a t-piece and D) MN with the spacer. Performance was evaluated in terms of: 1) Mass median aerodynamic diameter (MMAD); 2) Geometric standard deviation (GSD), 3) Fine particle dose (FPD), 4) Fine particle fraction (FPF), 5) Inhalable mass (IM), and 6) Recovery rate (RR). Both devices showed an adequate delivery of AZLI during MV, with MMAD between 2.4-2.5 µm and 87% of FPF. The FPD (38.8 and 31.7), IM (44.8 and 36.1) and RR (30 and 24) were similar for AS and MN respectively. Nebulizer aerosol delivery increased (50 and 70% respectively) for both nebulizers when using the spacer. Both AS and MN showed a good aerosol delivery profile for AZLI during in vitro mechanical ventilation. Better aerosol delivery performance was obtained using the spacer.