Author, as appears in the article.: Perez-Fernandez, Cristian; Morales-Navas, Miguel; Guardia-Escote, Laia; Colomina, Maria Teresa; Gimenez, Estela; Santed, Fernando Sanchez;
Department: Psicologia
URV's Author/s: Colomina Fosch, Maria Teresa / Guardia Escoté, Laia
Keywords: Weaning Spatial memory Rat Perinatal period Organophosphates Organophosphate Old age Nonhuman Neonatal exposure Motor performance Morris water maze test Morris water maze Male Locomotion Learning Juvenile Insecticide chlorpyrifos Hypomotricity Hypoalgesia Female mice Female Elevated plus maze test Early-onset Developmental chlorpyrifos Controlled study Compulsivity Compulsion Cognitive function Cognition Chlorpyrifos Brain Behavioral alterations Article Anxiety Animal model Animal experiment Animal behavior Aging Aged
Abstract: The molecular and behavioral effects of the developmental exposure to low doses of Chlorpyrifos (CPF) have been intensively studied in young (neonates and adolescents), and adult animals. However, no study examined influences of developmental CPF exposure in older adult or geriatric rats. This is relevant as such ages are generally linked to cognitive decline and the onset of specific neurodegenerative disorders, some of them previously associated with CPF exposure in both preclinical and human studies. 1 mg/kg/mL of CPF was orally administered to both male and female Wistar rats from Postnatal day 10 to 15. Animals' spatial memory, learning, compulsivity, motricity, and anxiety were analyzed with Morris Water Maze (15-16 months of age) and the Plus-maze (at 18 months of age). Results showed that postnatal CPF exposure did not alter either spatial memory, compulsive-like behaviors, or anxiety levels in late-adult rats. However, CPF exposed rats were hyposensitive to brief disruptions (Probe stage) following the learning phase and showed a general decrease in locomotor activity in both paradigms. These data are relevant as it is the first time that developmental exposure to CPF has been studied at such a late age, observing important effects in locomotor activity that could be linked to specific pathologies previously associated with CPF effects in people. Future studies should extend these findings to other behaviors and molecular outcomes.
Thematic Areas: Zootecnia / recursos pesqueiros Toxicology Saúde coletiva Química Psicología Pharmacology & pharmacy Odontología Neurosciences Neuroscience (miscellaneous) Neuroscience (all) Medicina veterinaria Medicina ii Medicina i Matemática / probabilidade e estatística Interdisciplinar General neuroscience General medicine Farmacia Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: mariateresa.colomina@urv.cat
Author identifier: 0000-0002-5619-4874
Record's date: 2024-07-27
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.sciencedirect.com/science/article/pii/S0161813X21000802?via%3Dihub
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Neurotoxicology. 86 69-77
APA: Perez-Fernandez, Cristian; Morales-Navas, Miguel; Guardia-Escote, Laia; Colomina, Maria Teresa; Gimenez, Estela; Santed, Fernando Sanchez; (2021). Pesticides and aging: Preweaning exposure to Chlorpyrifos induces a general hypomotricity state in late-adult rats. Neurotoxicology, 86(), 69-77. DOI: 10.1016/j.neuro.2021.07.002
Article's DOI: 10.1016/j.neuro.2021.07.002
Entity: Universitat Rovira i Virgili
Journal publication year: 2021
Publication Type: Journal Publications
Repositori URV