Articles producció científica> Química Analítica i Química Orgànica

Rhodium-catalysed ortho-alkynylation of nitroarenes

  • Identification data

    Identifier: imarina:9231661
    Authors:
    Tan, EricMontesinos-Magraner, MarcGarcia-Morales, CristinaMayans, Joan GuillemEchavarren, Antonio M.
    Abstract:
    The ortho-alkynylation of nitro-(hetero)arenes takes place in the presence of a Rh(iii) catalyst to deliver a wide variety of alkynylated nitroarenes regioselectively. These interesting products could be further derivatized by selective reduction of the nitro group or palladium-catalysed couplings. Experimental and computational mechanistic studies demonstrate that the reaction proceeds via a turnover-limiting electrophilic C-H metalation ortho to the strongly electron-withdrawing nitro group.
  • Others:

    Author, as appears in the article.: Tan, Eric; Montesinos-Magraner, Marc; Garcia-Morales, Cristina; Mayans, Joan Guillem; Echavarren, Antonio M.;
    Department: Química Analítica i Química Orgànica
    URV's Author/s: ECHAVARREN PABLOS, ANTONIO / Mayans Peñarrubia, Joan Guillem
    Keywords: ]+ catalyst Versatile Substitution Selective reduction Selective catalytic reduction Rhodium-catalyzed Rhodium compounds Palladium-catalyzed Nitroarenes Nitro group Metalations Mechanistic studies Heterocycles Direct arylation Chemistry Catalyzed coupling C-h alkynylation Bromoalkynes Bond formation Arenes Alkynylations Activation
    Abstract: The ortho-alkynylation of nitro-(hetero)arenes takes place in the presence of a Rh(iii) catalyst to deliver a wide variety of alkynylated nitroarenes regioselectively. These interesting products could be further derivatized by selective reduction of the nitro group or palladium-catalysed couplings. Experimental and computational mechanistic studies demonstrate that the reaction proceeds via a turnover-limiting electrophilic C-H metalation ortho to the strongly electron-withdrawing nitro group.
    Thematic Areas: Química Materiais Interdisciplinar General chemistry Farmacia Ciências biológicas iii Ciências biológicas i Chemistry, multidisciplinary Chemistry (miscellaneous) Chemistry (all) Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: antoniomaria.echavarren@urv.cat
    Author identifier: 0000-0002-6418-7930
    Record's date: 2024-07-27
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://pubs.rsc.org/en/content/articlelanding/2021/SC/D1SC04527J
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Chemical Science. 12 (44): 14731-14739
    APA: Tan, Eric; Montesinos-Magraner, Marc; Garcia-Morales, Cristina; Mayans, Joan Guillem; Echavarren, Antonio M.; (2021). Rhodium-catalysed ortho-alkynylation of nitroarenes. Chemical Science, 12(44), 14731-14739. DOI: 10.1039/d1sc04527j
    Article's DOI: 10.1039/d1sc04527j
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2021
    Publication Type: Journal Publications
  • Keywords:

    Chemistry (Miscellaneous),Chemistry, Multidisciplinary
    ]+ catalyst
    Versatile
    Substitution
    Selective reduction
    Selective catalytic reduction
    Rhodium-catalyzed
    Rhodium compounds
    Palladium-catalyzed
    Nitroarenes
    Nitro group
    Metalations
    Mechanistic studies
    Heterocycles
    Direct arylation
    Chemistry
    Catalyzed coupling
    C-h alkynylation
    Bromoalkynes
    Bond formation
    Arenes
    Alkynylations
    Activation
    Química
    Materiais
    Interdisciplinar
    General chemistry
    Farmacia
    Ciências biológicas iii
    Ciências biológicas i
    Chemistry, multidisciplinary
    Chemistry (miscellaneous)
    Chemistry (all)
    Astronomia / física
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