Articles producció científica> Infermeria

Comparative Efficacy and Safety of Anterograde vs. Retrograde Iodine Staining During Esophageal Chromoendoscopy: A Single-Center, Prospective, Parallel-Group, Randomized, Controlled, Single-Blind Trial

  • Identification data

    Identifier: imarina:9241752
    Authors:
    Tian, XYang, WChen, WQ
    Abstract:
    Background and Aim: Chromoendoscopy with iodine staining is an important diagnostic method for esophageal carcinomas or precancerous lesions. Unfortunately, iodine staining can be associated with numerous adverse events (AEs). We found that the starting position of spraying iodine solution is likely the main reason of causing AEs. We conducted this work to determine whether clinical outcomes from anterograde iodine staining were superior to those achieved after retrograde iodine staining.Methods: A total of 134 subjects with a health risk appraisal flushing (HRA-F) score of >6 for esophageal cancer were randomly assigned to receive anterograde or retrograde iodine staining in the esophagus. The primary endpoints were the pain and the amount of iodine solution consumption. The secondary endpoints were iodine-staining effect, detection yield, and response to starch indicator.Results: Nine patients suffered from pain and six patients revealed positive response to starch indicator in retrograde iodine-staining group; however, no patient reported pain (0/67) and all patients revealed a negative response to starch indicator in anterograde iodine-staining group. The amount of iodine solution consumption in anterograde iodine-staining group (4.97 mL) was significantly lower than that (6.23 mL) in retrograde iodine-staining group; however, the iodine-staining effect and detection yield were comparable between the two groups.Conclusions: Anterograde iodine staining during Lugol chromoendoscopy appears to be as effective, but significantly safer than retrograde iodine staining.
  • Others:

    Author, as appears in the article.: Tian, X; Yang, W; Chen, WQ
    Department: Infermeria
    URV's Author/s: Tian, Xu
    Keywords: Staining Risk Neoplasia Iodine solution Esophageal cancer Endoscopic screening Chromoendoscopy Cancer statistics
    Abstract: Background and Aim: Chromoendoscopy with iodine staining is an important diagnostic method for esophageal carcinomas or precancerous lesions. Unfortunately, iodine staining can be associated with numerous adverse events (AEs). We found that the starting position of spraying iodine solution is likely the main reason of causing AEs. We conducted this work to determine whether clinical outcomes from anterograde iodine staining were superior to those achieved after retrograde iodine staining.Methods: A total of 134 subjects with a health risk appraisal flushing (HRA-F) score of >6 for esophageal cancer were randomly assigned to receive anterograde or retrograde iodine staining in the esophagus. The primary endpoints were the pain and the amount of iodine solution consumption. The secondary endpoints were iodine-staining effect, detection yield, and response to starch indicator.Results: Nine patients suffered from pain and six patients revealed positive response to starch indicator in retrograde iodine-staining group; however, no patient reported pain (0/67) and all patients revealed a negative response to starch indicator in anterograde iodine-staining group. The amount of iodine solution consumption in anterograde iodine-staining group (4.97 mL) was significantly lower than that (6.23 mL) in retrograde iodine-staining group; however, the iodine-staining effect and detection yield were comparable between the two groups.Conclusions: Anterograde iodine staining during Lugol chromoendoscopy appears to be as effective, but significantly safer than retrograde iodine staining.
    Thematic Areas: Oncology Medicine, research & experimental Medicine, general & internal Medicine (miscellaneous) Medicine (all) Medicina ii General medicine Farmacia Ciências biológicas i Biodiversidade
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: xu.tian@estudiants.urv.cat
    Record's date: 2024-07-27
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.764111/full
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Frontiers Of Medicine. 8
    APA: Tian, X; Yang, W; Chen, WQ (2021). Comparative Efficacy and Safety of Anterograde vs. Retrograde Iodine Staining During Esophageal Chromoendoscopy: A Single-Center, Prospective, Parallel-Group, Randomized, Controlled, Single-Blind Trial. Frontiers Of Medicine, 8(), -. DOI: 10.3389/fmed.2021.764111
    Article's DOI: 10.3389/fmed.2021.764111
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2021
    Publication Type: Journal Publications
  • Keywords:

    Medicine (Miscellaneous),Medicine, General & Internal,Medicine, Research & Experimental,Oncology
    Staining
    Risk
    Neoplasia
    Iodine solution
    Esophageal cancer
    Endoscopic screening
    Chromoendoscopy
    Cancer statistics
    Oncology
    Medicine, research & experimental
    Medicine, general & internal
    Medicine (miscellaneous)
    Medicine (all)
    Medicina ii
    General medicine
    Farmacia
    Ciências biológicas i
    Biodiversidade
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