Author, as appears in the article.: Escobar-Martinez, Ivan; Arreaza-Gil, Veronica; Muguerza, Begona; Arola-Arnal, Anna; Isabel Bravo, Francisca; Torres-Fuentes, Cristina; Suarez, Manuel;
Department: Bioquímica i Biotecnologia
URV's Author/s: Arola Arnal, Anna / Arreaza Gil, Verónica / Bravo Vázquez, Francisca Isabel / Muguerza Marquínez, Maria Begoña / Suárez Recio, Manuel / Torres Fuentes, Cristina
Keywords: Polyphenols Phenolic compounds Microbiota Metabolic syndrome Kinetics Gspe Genes Flavanols Expression Circadian rhythms Circadian clock Bioavailability Absorption
Abstract: Scope Phenolic compounds are bioactive molecules that are associated with several health benefits. Metabolization and absorption are the main determinants of their bioavailability and bioactivity. Thus, the study of the factors that modulate these processes, such as sex or diet is essential. Recently, it has been shown that biological rhythms may also play a key role. Hence, the aim of this study is to evaluate if the bioavailability of a grape proanthocyanidin extract (GSPE) is affected by the administration time in an animal model of metabolic syndrome (MetS). Methods and Results Female and male Fischer 344 rats are fed either a standard or a cafeteria diet (CAF) for 9 weeks, and an oral dose of GSPE (25 mg kg(-1)) is daily administered either at 8:00 am (zeitgeber time (ZT)-0) or at 8:00 pm (ZT-12) during the last 4 weeks. Plasma phenolic compounds are then quantified by liquid chromatography/electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS). Phase-II and gut microbiota-derived phenolic metabolites are affected by ZT in all conditions or only in obese rats, respectively. CAF feeding affected the bioavailability of phenolic acids and free flavan-3-ols. Differences due to sex are also observed. Conclusion These findings demonstrate that ZT, diet, and sex are key factors influencing phenolic compounds bioavailability.
Thematic Areas: Saúde coletiva Química Nutrição Medicina veterinaria Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biotechnology Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: veronica.arreaza@urv.cat veronica.arreaza@urv.cat veronica.arreaza@urv.cat manuel.suarez@urv.cat franciscaisabel.bravo@urv.cat anna.arola@urv.cat begona.muguerza@urv.cat cristina.torres@urv.cat
Author identifier: 0000-0002-8301-2095 0000-0002-8301-2095 0000-0002-8301-2095 0000-0003-0122-8253 0000-0002-6468-3088 0000-0001-6529-1345 0000-0001-7384-8588 0000-0002-2917-6910
Record's date: 2024-09-21
Papper version: info:eu-repo/semantics/publishedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Molecular Nutrition & Food Research. 66 (3): e2100552-
APA: Escobar-Martinez, Ivan; Arreaza-Gil, Veronica; Muguerza, Begona; Arola-Arnal, Anna; Isabel Bravo, Francisca; Torres-Fuentes, Cristina; Suarez, Manuel; (2022). Administration Time Significantly Affects Plasma Bioavailability of Grape Seed Proanthocyanidins Extract in Healthy and Obese Fischer 344 Rats. Molecular Nutrition & Food Research, 66(3), e2100552-. DOI: 10.1002/mnfr.202100552
Entity: Universitat Rovira i Virgili
Journal publication year: 2022
Publication Type: Journal Publications
Repositori URV