Author, as appears in the article.: Andreu-Bernabeu Á; Díaz-Caneja CM; Costas J; De Hoyos L; Stella C; Gurriarán X; Alloza C; Fañanás L; Bobes J; González-Pinto A; Crespo-Facorro B; Martorell L; Vilella E; Muntané G; Nacher J; Molto MD; Aguilar EJ; Parellada M; Arango C; González-Peñas J
Department: Medicina i Cirurgia
URV's Author/s: Martorell Bonet, Lourdes / Vilella Cuadrada, Elisabet
Abstract: Previous research suggests an association of loneliness and social isolation (LNL-ISO) with schizophrenia. Here, we demonstrate a LNL-ISO polygenic score contribution to schizophrenia risk in an independent case-control sample (N = 3,488). We then subset schizophrenia predisposing variation based on its effect on LNL-ISO. We find that genetic variation with concordant effects in both phenotypes shows significant SNP-based heritability enrichment, higher polygenic contribution in females, and positive covariance with mental disorders such as depression, anxiety, attention-deficit hyperactivity disorder, alcohol dependence, and autism. Conversely, genetic variation with discordant effects only contributes to schizophrenia risk in males and is negatively correlated with those disorders. Mendelian randomization analyses demonstrate a plausible bi-directional causal relationship between LNL-ISO and schizophrenia, with a greater effect of LNL-ISO liability on schizophrenia than vice versa. These results illustrate the genetic footprint of LNL-ISO on schizophrenia.© 2022. The Author(s).
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Physics and astronomy (miscellaneous) Physics and astronomy (all) Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Geociências General physics and astronomy General medicine General chemistry General biochemistry,genetics and molecular biology Farmacia Engenharias iv Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência da computação Chemistry (miscellaneous) Chemistry (all) Biotecnología Biodiversidade Biochemistry, genetics and molecular biology (miscellaneous) Biochemistry, genetics and molecular biology (all) Astronomia / física Antropologia / arqueologia
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: lourdes.martorell@urv.cat elisabet.vilella@urv.cat
Author identifier: 0000-0003-4999-2197 0000-0002-1887-5919
Record's date: 2024-09-07
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.nature.com/articles/s41467-021-27598-6
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Nature Communications. 13 (1): 51-51
APA: Andreu-Bernabeu Á; Díaz-Caneja CM; Costas J; De Hoyos L; Stella C; Gurriarán X; Alloza C; Fañanás L; Bobes J; González-Pinto A; Crespo-Facorro B; Mart (2022). Polygenic contribution to the relationship of loneliness and social isolation with schizophrenia. Nature Communications, 13(1), 51-51. DOI: 10.1038/s41467-021-27598-6
Article's DOI: 10.1038/s41467-021-27598-6
Entity: Universitat Rovira i Virgili
Journal publication year: 2022
Publication Type: Journal Publications
Repositori URV