Author, as appears in the article.: Roso-Llorach A; Serra-Picamal X; Cos FX; Pallejà-Millán M; Mateu L; Rosell A; Almirante B; Ferrer J; Gasa M; Gudiol C; Moreno AM; Morales-Rull JL; Rexach M; Sabater G; Auguet T; Vidal F; Lerida A; Rebull J; Khunti K; Argimon JM; Paredes R
Department: Medicina i Cirurgia
URV's Author/s: Auguet Quintillà, Maria Teresa / Vidal Marsal, Francisco
Keywords: Socioeconomic characteristics Risk factors Hospital mortality Coronavirus disease 2019 (covid-19) Clinical characteristics
Abstract: Background: The changes in shield strategies, treatments, emergence variants, and healthcare pathways might shift the profile and outcome of patients hospitalized with COVID-19 in successive waves of the outbreak. Methods: We retrospectively analysed the characteristics and in-hospital outcomes of all patients admitted with COVID-19 in eight university hospitals of Catalonia (North-East Spain) between Feb 28, 2020 and Feb 28, 2021. Using a 7-joinpoint regression analysis, we split admissions into four waves. The main hospital outcomes included 30-day mortality and admission to intensive care unit (ICU). Findings: The analysis included 17,027 subjects admitted during the first wave (6800; 39.9%), summer wave (1807; 10.6%), second wave (3804; 22.3%), and third wave (4616; 27.1%). The highest 30-day mortality rate was reported during the first wave (17%) and decreased afterwards, remaining stable at 13% in the second and third waves (overall 30% reduction); the lowest mortality was reported during the summer wave (8%, 50% reduction). ICU admission became progressively more frequent during successive waves. In Cox regression analysis, the main factors contributing to differences in 30-day mortality were the epidemic wave, followed by gender, age, diabetes, chronic kidney disease, and neoplasms. Interpretation: Although in-hospital COVID-19 mortality remains high, it decreased substantially after the first wave and is highly dependent of patient's characteristics and ICU availability. Highest mortality reductions occurred during a wave characterized by younger individuals, an increasingly frequent scenario as vaccination campaigns progress. Funding: This work did not receive specific funding.
Thematic Areas: Public health, environmental and occupational health Infectious diseases Epidemiology
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: mariateresa.auguet@urv.cat francesc.vidal@urv.cat
Author identifier: 0000-0003-0396-6428 0000-0002-6692-6186
Record's date: 2024-09-07
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://pubmed.ncbi.nlm.nih.gov/35018339/
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Global Epidemiology. 4 100071-
APA: Roso-Llorach A; Serra-Picamal X; Cos FX; Pallejà-Millán M; Mateu L; Rosell A; Almirante B; Ferrer J; Gasa M; Gudiol C; Moreno AM; Morales-Rull JL; Rex (2022). Evolving mortality and clinical outcomes of hospitalized subjects during successive COVID-19 waves in Catalonia, Spain. Global Epidemiology, 4(), 100071-. DOI: 10.1016/j.gloepi.2022.100071
Article's DOI: 10.1016/j.gloepi.2022.100071
Entity: Universitat Rovira i Virgili
Journal publication year: 2022
Publication Type: Journal Publications