Author, as appears in the article.: Yeregui E; Masip J; Viladés C; Domingo P; Pacheco YM; Blanco J; Mallolas J; Alba V; Vargas M; García-Pardo G; Negredo E; Olona M; Vidal-González J; Peraire M; Martí A; Reverté L; Gómez-Bertomeu F; Leal M; Vidal F; Peraire J; Rull A

Department: Medicina i Cirurgia

URV's Author/s: Gomez Bertomeu, Frederic-Francesc / Masip Morcillo, Jenifer / Peraire Forner, José Joaquin / RULL AIXA, ANNA

Keywords: Poor immune recovery Insulin-resistance Immunodiscordant response Hiv Antiretroviral therapy Adipokines responses poor immune recovery metabolic syndrome mediators inflammation individuals immunodiscordant response hiv-1-infected patients hiv antiretroviral therapy adipose-tissue adiponectin

Abstract: A significant proportion of people living with HIV (PLHIV) who successfully achieve virological suppression fail to recover CD4+ T-cell counts. Since adipose tissue has been discovered as a key immune organ, this study aimed to assess the role of adipokines in the HIV immunodiscordant response. This is a multicenter prospective study including 221 PLHIV starting the first antiretroviral therapy (ART) and classified according to baseline CD4+ T-cell counts/µL (controls > 200 cells/µL and cases ≤ 200 cells/µL). Immune failure recovery was considered when cases did not reach more than 250 CD4+ T cells/µL at 144 weeks (immunological nonresponders, INR). Circulating adipokine concentrations were longitudinally measured using enzyme-linked immunosorbent assays. At baseline, apelin receptor (APLNR) and zinc-alpha-2-glycoprotein (ZAG) concentrations were significantly lower in INRs than in immunological responders (p = 0.043 and p = 0.034), and they remained lower during all ART follow-up visits (p = 0.044 and p = 0.028 for APLNR, p = 0.038 and p = 0.010 for ZAG, at 48 and 144 weeks, respectively). ZAG levels positively correlated with retinol-binding protein 4 (RBP4) levels (p < 0.01), and low circulating RBP4 concentrations were related to a low CD4+ T-cell gain (p = 0.018 and p = 0.039 at 48 and 144 weeks, respectively). Multiple regression adjusted for clinical variables and adipokine concentrations confirmed both low APLNR and RBP4 as independent predictors for CD4+ T cells at 144 weeks (p < 0.001). In conclusion, low APLNR and RBP4 concentrations were associated with poor immune recovery in treated PLHIV and could be considered predictive biomarkers of a discordant immunological response.

Thematic Areas: Zootecnia / recursos pesqueiros Spectroscopy Saúde coletiva Química Psicología Physical and theoretical chemistry Organic chemistry Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Inorganic chemistry Geociências Farmacia Engenharias iv Engenharias ii Engenharias i Educação física Computer science applications Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, multidisciplinary Catalysis Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: jenifer.masip@urv.cat frederic-francesc.gomez@urv.cat joaquim.peraire@urv.cat jenifer.masip@urv.cat

Author identifier: 0000-0002-8039-2889 0000-0001-7808-5479

Record's date: 2023-02-23

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.mdpi.com/1422-0067/23/4/2202

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: International Journal Of Molecular Sciences. 23 (4):

APA: Yeregui E; Masip J; Viladés C; Domingo P; Pacheco YM; Blanco J; Mallolas J; Alba V; Vargas M; García-Pardo G; Negredo E; Olona M; Vidal-González J; Pe (2022). Adipokines as New Biomarkers of Immune Recovery: Apelin Receptor, RBP4 and ZAG Are Related to CD4+ T-Cell Reconstitution in PLHIV on Suppressive Antiretroviral Therapy. International Journal Of Molecular Sciences, 23(4), -. DOI: 10.3390/ijms23042202

Article's DOI: 10.3390/ijms23042202

Entity: Universitat Rovira i Virgili

Journal publication year: 2022

Publication Type: Journal Publications