Articles producció científica> Medicina i Cirurgia

Adipokines as New Biomarkers of Immune Recovery: Apelin Receptor, RBP4 and ZAG Are Related to CD4+ T-Cell Reconstitution in PLHIV on Suppressive Antiretroviral Therapy

  • Identification data

    Identifier: imarina:9245559
    Authors:
    Yeregui, ElenaMasip, JeniferVilades, ConsueloDomingo, PerePacheco, Yolanda MBlanco, JuliaMallolas, JosepAlba, VeronicaVargas, MontserratGarcia-Pardo, GracianoNegredo, EugeniaOlona, MontserratVidal-Gonzalez, JuditPeraire, MariaMarti, AnnaReverte, LaiaGomez-Bertomeu, FredericLeal, ManuelVidal, FrancescPeraire, JoaquimRull, Anna
    Abstract:
    A significant proportion of people living with HIV (PLHIV) who successfully achieve virological suppression fail to recover CD4+ T-cell counts. Since adipose tissue has been discovered as a key immune organ, this study aimed to assess the role of adipokines in the HIV immunodiscordant response. This is a multicenter prospective study including 221 PLHIV starting the first antiretroviral therapy (ART) and classified according to baseline CD4+ T-cell counts/µL (controls > 200 cells/µL and cases ≤ 200 cells/µL). Immune failure recovery was considered when cases did not reach more than 250 CD4+ T cells/µL at 144 weeks (immunological nonresponders, INR). Circulating adipokine concentrations were longitudinally measured using enzyme-linked immunosorbent assays. At baseline, apelin receptor (APLNR) and zinc-alpha-2-glycoprotein (ZAG) concentrations were significantly lower in INRs than in immunological responders (p = 0.043 and p = 0.034), and they remained lower during all ART follow-up visits (p = 0.044 and p = 0.028 for APLNR, p = 0.038 and p = 0.010 for ZAG, at 48 and 144 weeks, respectively). ZAG levels positively correlated with retinol-binding protein 4 (RBP4) levels (p < 0.01), and low circulating RBP4 concentrations were related to a low CD4+ T-cell gain (p = 0.018 and p = 0.039 at 48 and 144 weeks, respectively). Multiple regression adjusted for clinical variables and adipokine concentrations confirmed both low APLNR and RBP4 as independent predictors for CD4+ T cells at 144 weeks (p < 0.001). In conclusion, low APLNR and RBP4 concentrations were associated with poor immune recovery in treated PLHIV and could be considered predictive biomarkers of a discordant immunological response.
  • Others:

    Author, as appears in the article.: Yeregui, Elena; Masip, Jenifer; Vilades, Consuelo; Domingo, Pere; Pacheco, Yolanda M; Blanco, Julia; Mallolas, Josep; Alba, Veronica; Vargas, Montserrat; Garcia-Pardo, Graciano; Negredo, Eugenia; Olona, Montserrat; Vidal-Gonzalez, Judit; Peraire, Maria; Marti, Anna; Reverte, Laia; Gomez-Bertomeu, Frederic; Leal, Manuel; Vidal, Francesc; Peraire, Joaquim; Rull, Anna
    Department: Medicina i Cirurgia
    URV's Author/s: Garcia Pardo, Graciano / Gomez Bertomeu, Frederic-Francesc / Martí Zaragoza, Àlex / Masip Morcillo, Jenifer / Olona Cabases, Maria Montserrat / Peraire Forner, José Joaquin / RULL AIXA, ANNA / Vidal Marsal, Francisco / Vilades Laborda, Consuelo Gloria / Yeregui Etxeberria, Elena
    Keywords: Viral load Retinol-binding proteins, plasma Rbp4 protein, human Prospective studies Poor immune recovery Middle aged Male Insulin-resistance Immunodiscordant response Humans Hiv-1 Hiv infections Hiv Female Cd4-positive t-lymphocytes Cd4 lymphocyte count Biomarkers Azgp1 protein, human Apelin receptors Antiretroviral therapy, highly active Antiretroviral therapy Adult Adipokines responses poor immune recovery metabolic syndrome mediators inflammation individuals immunodiscordant response hiv-1-infected patients hiv antiretroviral therapy adipose-tissue adiponectin
    Abstract: A significant proportion of people living with HIV (PLHIV) who successfully achieve virological suppression fail to recover CD4+ T-cell counts. Since adipose tissue has been discovered as a key immune organ, this study aimed to assess the role of adipokines in the HIV immunodiscordant response. This is a multicenter prospective study including 221 PLHIV starting the first antiretroviral therapy (ART) and classified according to baseline CD4+ T-cell counts/µL (controls > 200 cells/µL and cases ≤ 200 cells/µL). Immune failure recovery was considered when cases did not reach more than 250 CD4+ T cells/µL at 144 weeks (immunological nonresponders, INR). Circulating adipokine concentrations were longitudinally measured using enzyme-linked immunosorbent assays. At baseline, apelin receptor (APLNR) and zinc-alpha-2-glycoprotein (ZAG) concentrations were significantly lower in INRs than in immunological responders (p = 0.043 and p = 0.034), and they remained lower during all ART follow-up visits (p = 0.044 and p = 0.028 for APLNR, p = 0.038 and p = 0.010 for ZAG, at 48 and 144 weeks, respectively). ZAG levels positively correlated with retinol-binding protein 4 (RBP4) levels (p < 0.01), and low circulating RBP4 concentrations were related to a low CD4+ T-cell gain (p = 0.018 and p = 0.039 at 48 and 144 weeks, respectively). Multiple regression adjusted for clinical variables and adipokine concentrations confirmed both low APLNR and RBP4 as independent predictors for CD4+ T cells at 144 weeks (p < 0.001). In conclusion, low APLNR and RBP4 concentrations were associated with poor immune recovery in treated PLHIV and could be considered predictive biomarkers of a discordant immunological response.
    Thematic Areas: Zootecnia / recursos pesqueiros Spectroscopy Saúde coletiva Química Psicología Physical and theoretical chemistry Organic chemistry Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Inorganic chemistry Geociências Farmacia Engenharias iv Engenharias ii Engenharias i Educação física Computer science applications Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, multidisciplinary Catalysis Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: graciano.garcia@urv.cat frederic-francesc.gomez@urv.cat joaquim.peraire@urv.cat consuelo.vilades@urv.cat elena.yeregui@estudiants.urv.cat alex.marti@estudiants.urv.cat jenifer.masip@estudiants.urv.cat jenifer.masip@estudiants.urv.cat francesc.vidal@urv.cat
    Author identifier: 0000-0002-8039-2889 0000-0001-7808-5479 0000-0002-2991-9593 0000-0002-6692-6186
    Record's date: 2025-02-19
    Paper version: info:eu-repo/semantics/publishedVersion
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Paper original source: International Journal Of Molecular Sciences. 23 (4): 2202-
    APA: Yeregui, Elena; Masip, Jenifer; Vilades, Consuelo; Domingo, Pere; Pacheco, Yolanda M; Blanco, Julia; Mallolas, Josep; Alba, Veronica; Vargas, Montserr (2022). Adipokines as New Biomarkers of Immune Recovery: Apelin Receptor, RBP4 and ZAG Are Related to CD4+ T-Cell Reconstitution in PLHIV on Suppressive Antiretroviral Therapy. International Journal Of Molecular Sciences, 23(4), 2202-. DOI: 10.3390/ijms23042202
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2022
    Publication Type: Journal Publications
  • Keywords:

    Biochemistry & Molecular Biology,Catalysis,Chemistry, Multidisciplinary,Computer Science Applications,Inorganic Chemistry,Medicine (Miscellaneous),Molecular Biology,Organic Chemistry,Physical and Theoretical Chemistry,Spectroscopy
    Viral load
    Retinol-binding proteins, plasma
    Rbp4 protein, human
    Prospective studies
    Poor immune recovery
    Middle aged
    Male
    Insulin-resistance
    Immunodiscordant response
    Humans
    Hiv-1
    Hiv infections
    Hiv
    Female
    Cd4-positive t-lymphocytes
    Cd4 lymphocyte count
    Biomarkers
    Azgp1 protein, human
    Apelin receptors
    Antiretroviral therapy, highly active
    Antiretroviral therapy
    Adult
    Adipokines
    responses
    poor immune recovery
    metabolic syndrome
    mediators
    inflammation
    individuals
    immunodiscordant response
    hiv-1-infected patients
    hiv
    antiretroviral therapy
    adipose-tissue
    adiponectin
    Zootecnia / recursos pesqueiros
    Spectroscopy
    Saúde coletiva
    Química
    Psicología
    Physical and theoretical chemistry
    Organic chemistry
    Odontología
    Nutrição
    Molecular biology
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Inorganic chemistry
    Geociências
    Farmacia
    Engenharias iv
    Engenharias ii
    Engenharias i
    Educação física
    Computer science applications
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Ciência da computação
    Chemistry, multidisciplinary
    Catalysis
    Biotecnología
    Biodiversidade
    Biochemistry & molecular biology
    Astronomia / física
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