Articles producció científica> Medicina i Cirurgia

DBP rs7041 and DHCR7 rs3829251 are Linked to CD4(+) Recovery in HIV Patients on Antiretroviral Therapy

  • Identification data

    Identifier: imarina:9246069
  • Authors:

    Resino, Salvador
    Jimenez-Sousa, Maria Angeles
    Blanco, Julia
    Pacheco, Yolanda M.
    del Romero, Jorge
    Peraire, Joaquim
    Virseda-Berdices, Ana
    Munoz-Gomez, Maria Jose
    Galera-Penaranda, Carlos
    Garcia-Fraile, Lucio Jesus
    Benito, Jose M.
    Rallon, Norma
    Epiclin, SARNPR
  • Others:

    Author, as appears in the article.: Resino, Salvador; Jimenez-Sousa, Maria Angeles; Blanco, Julia; Pacheco, Yolanda M.; del Romero, Jorge; Peraire, Joaquim; Virseda-Berdices, Ana; Munoz-Gomez, Maria Jose; Galera-Penaranda, Carlos; Garcia-Fraile, Lucio Jesus; Benito, Jose M.; Rallon, Norma;Epiclin, SARNPR
    Department: Medicina i Cirurgia
    URV's Author/s: Peraire Forner, José Joaquin
    Keywords: Vitamin T-cell recovery Snp Liver fibrosis Infected patients Immune reconstitution Hiv Disease progression Dhcr7 Dbp D-receptor gene D-binding protein D serum-levels Common genetic-determinants Cd4(+) t cells Antiretroviral therapy 25-hydroxyvitamin d
    Abstract: Background: The lack of the recovery of CD4(+) T-cells (CD4(+) recovery) among immunodeficiency virus (HIV)-infected patients on antiretroviral therapy (ART) is not well known. We aimed to analyze the association between single nucleotide polymorphisms (SNPs) underlying vitamin D metabolism and the CD4(+) recovery in naive HIV-infected patients who started ART with low baseline CD4(+).Methods: We conducted a retrospective study in 411 naive individuals with plasma HIV load >200 copies/mL and CD4(+) <200 cells/mm(3). During 24 months of follow-up, all patients had plasma HIV load Results: CD4(+) recovery was higher in patients carrying DBP rs7041 AA genotype (AA versus CC/AC) and DHCR7 rs3829251 AA genotype (AA versus GG/AG) (p-value < 0.05). DBP rs7041 AA genotype was linked to increase in CD4(+) (adjusted arithmetic mean ratio (aAMR) = 1.22; q-value = 0.011), increase in CD4(+) >= P75th [adjusted odds ratio (aOR) = 2.31; q-value = 0.005], slope of CD4(+) recovery (aAMR = 1.25; q-value = 0.008), slope of CD4(+) recovery >= P75th (aOR = 2.55; q-value = 0.005) and achievement of CD4(+) >= 500 cells/mm(3) (aOR = 1.89; q-value = 0.023). Besides, DHCR7 rs3829251 AA genotype was related to increase in CD4(+) (aAMR = 1.43; q-value = 0.031), increase in CD4(+) >= P75th (aOR = 3.92; q-value = 0.030), slope of CD4(+) recovery (aAMR = 1.40; q-value = 0.036), slope of CD4(+) recovery >= P75th (aOR = 3.42; q-value = 0.031) and achievement of CD4(+) >= 500 cells/mm(3) (aOR = 5.68; q-value = 0.015).Conclusion: In summary, DHCR7 rs3829251 and DBP rs7041 polymorphisms were associated with CD4(+) recovery in HIV-infected patients who started cART with low CD4(+) T-cell counts.
    Thematic Areas: Psicología Pharmacology (medical) Pharmacology & pharmacy Pharmacology Odontología Medicina veterinaria Medicina ii Medicina i Interdisciplinar Farmacia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología Biodiversidade
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: joaquim.peraire@urv.cat
    Author identifier: 0000-0001-7808-5479
    Record's date: 2023-02-23
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.frontiersin.org/articles/10.3389/fphar.2021.773848/full
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Frontiers In Pharmacology. 12
    APA: Resino, Salvador; Jimenez-Sousa, Maria Angeles; Blanco, Julia; Pacheco, Yolanda M.; del Romero, Jorge; Peraire, Joaquim; Virseda-Berdices, Ana; Munoz- (2022). DBP rs7041 and DHCR7 rs3829251 are Linked to CD4(+) Recovery in HIV Patients on Antiretroviral Therapy. Frontiers In Pharmacology, 12(), -. DOI: 10.3389/fphar.2021.773848
    Article's DOI: 10.3389/fphar.2021.773848
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2022
    Publication Type: Journal Publications
  • Keywords:

    Pharmacology,Pharmacology & Pharmacy,Pharmacology (Medical)
    Vitamin
    T-cell recovery
    Snp
    Liver fibrosis
    Infected patients
    Immune reconstitution
    Hiv
    Disease progression
    Dhcr7
    Dbp
    D-receptor gene
    D-binding protein
    D serum-levels
    Common genetic-determinants
    Cd4(+) t cells
    Antiretroviral therapy
    25-hydroxyvitamin d
    Psicología
    Pharmacology (medical)
    Pharmacology & pharmacy
    Pharmacology
    Odontología
    Medicina veterinaria
    Medicina ii
    Medicina i
    Interdisciplinar
    Farmacia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Biotecnología
    Biodiversidade
  • Documents:

  • Cerca a google

    Search to google scholar