Author, as appears in the article.: Satue-Gracia, Eva M.; Vila-Corcoles, Angel; De Diego-Cabanes, Cinte; Vila-Rovira, Angel; Torrente-Fraga, Cristina; Gomez-Bertomeu, Frederic; Hospital-Guardiola, Imma; Ochoa-Gondar, Olga; Martin-Lujan, Francisco;
Department: Medicina i Cirurgia
URV's Author/s: Gomez Bertomeu, Frederic-Francesc / Martín Lujan, Francisco Manuel
Keywords: Sars-cov-2 Risk Incidence Epidemiology Covid-19 Coronavirus
Abstract: & nbsp;Objective: To analyse susceptibility/risk of suffering COVID-19 among adults with distinct underlying medical conditions.& nbsp;Methods: Population-based cohort study involving 79,083 individuals >= 50 years old in Tarragona (Southern Catalonia, Spain). Baseline cohort characteristics (demographic, pre-existing comorbidities, chronic medications and vaccinations history) were established at study start (01/03/2020) and primary outcome was laboratory-confirmed COVID-19 occurred among cohort members throughout 01/03/2020-30/06/2020. Risk of suffering COVID-19 was evaluated by Cox regression, estimating multi -variable hazard ratios (HRs) adjusted for age/sex and pre-existing comorbidities.& nbsp;Results: Across study period, 536 laboratory-confirmed COVID-19 cases were observed (mean incidence: 39.5 cases per 100,000 persons-week). In multivariable-analysis, increasing age/years (HR: 1.01; 95% CI: 1.00-1.02), nursing-home (HR: 20.19; 95% CI: 15.98-25.51), neurological disease (HR: 1.35; 95% CI: 1.03-1.77), taking diuretics (HR: 1.39; 95% CI: 1.10-1.75), antiplatelet (HR: 1.36; 95% CI: 1.05-1.76) and benzodiazepines (HR: 1.24; 95% CI: 1.00-1.53) increased risk; conversely, taking angiotensin-converting-enzyme inhibitors (HR: 0.78; 95% CI: 0.61-1.00), angiotensin-receptor-blockers (HR: 0.70; 95%CI: 0.51-0.96) and statins (HR: 0.75; 95% CI: 0.58-0.96) were associated with reduced risk. Among community-dwelling individuals, pre-existing cancer, renal and cardiac disease appeared also related with an increased risk, whereas influenza vaccination was associated with reduced risk.& nbsp;Conclusion: In a setting with relatively low incidence of COVID-19 across the first wave of pandemic period, increasing age, nursing-home residence and multiple comorbidities appear predisposing for COVID-19 among middle-aged/older adults. Conversely, statins, angiotensin-receptor blockers/inhibitors and influenza vaccination were related with decreased risk. (C)& nbsp;2021 Elsevier Espana, S.L.U. All rights reserved.
Thematic Areas: Saúde coletiva Odontología Medicine, general & internal Medicine (miscellaneous) Medicine (all) Medicina ii Medicina i General medicine Ciências biológicas ii
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: frederic-francesc.gomez@urv.cat paco.martin@urv.cat
Author identifier: 0000-0002-8039-2889 0000-0003-0359-3588
Record's date: 2024-09-07
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://www.sciencedirect.com/science/article/pii/S0025775321002402?via%3Dihub
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Medicina Clinica. 158 (6): 251-259
APA: Satue-Gracia, Eva M.; Vila-Corcoles, Angel; De Diego-Cabanes, Cinte; Vila-Rovira, Angel; Torrente-Fraga, Cristina; Gomez-Bertomeu, Frederic; Hospital- (2022). Susceptibility and risk of SARS-COV-2 infection among middle-aged and older adults in Tarragona area, Spain. Medicina Clinica, 158(6), 251-259. DOI: 10.1016/j.medcli.2021.03.027
Article's DOI: 10.1016/j.medcli.2021.03.027
Entity: Universitat Rovira i Virgili
Journal publication year: 2022
Publication Type: Journal Publications
Repositori URV