Author, as appears in the article.: Meler-Claramonte, Carla; Aviles-Jurado, Francesc Xavier; Vilaseca, Isabel; Terra, Ximena; Bragado, Paloma; Fuster, Gemma; Leon Vintro, Xavier; Camacho, Mercedes
Department: Medicina i Cirurgia Bioquímica i Biotecnologia
URV's Author/s: Avilés Jurado, Francisco Javier / Meler Claramonte, Carla / Terra Barbadora, Ximena
Keywords: Squamous-cell carcinoma Semaphorin-3f Occult lymph node metastases Neuropilin-2 Lymphangiogenesis Hnscc Head and neck squamous cell carcinoma Elective neck dissection vegf-c suppressor potent multifunctional modulators oral tongue occult lymph node metastases neuropilin-2 lymphangiogenesis hnscc head and neck squamous cell carcinoma head elective neck dissection class-3 semaphorins cancer 3f
Abstract: The expression of the semaphorin-3F (SEMA3F) and neuropilin-2 (NRP2) is involved in the regulation of lymphangiogenesis. The present study analyzes the relationship between the transcriptional expression of the SEMA3F-NRP2 genes and the presence of occult lymph node metastases in patients with cN0 head and neck squamous cell carcinomas. We analyzed the transcriptional expression of SEMA3F and NRP2 in a cohort of 53 patients with cN0 squamous cell carcinoma treated with an elective neck dissection. Occult lymph node metastases were found in 37.7% of the patients. Patients with occult lymph node metastases (cN0/pN+) had significantly lower SEMA3F expression values than patients without lymph node involvement (cN0/pN0). Considering the expression of the SEMA3F-NRP2 genes, patients were classified into two groups according to the risk of occult nodal metastasis: Group 1 (n = 34), high SEMA3F/low NRP2 expression, with a low risk of occult nodal involvement (14.7% cN0/pN+); Group 2 (n = 19), low SEMA3F or high SEMA3F/high NRP2 expression, with a high risk of occult nodal involvement (78.9% cN0/pN+). Multivariate analysis showed that patients in Group 2 had a 26.2 higher risk of lymph node involvement than patients in Group 1. There was a significant relationship between the transcriptional expression values of the SEMA3F-NRP2 genes and the risk of occult nodal metastases.
Thematic Areas: Oncology Medicina iii Cancer research
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: franciscojavier.aviles@urv.cat carla.meler@urv.cat ximena.terra@urv.cat
Author identifier: 0000-0001-5560-8097 0000-0003-2263-4306 0000-0003-1043-5844
Record's date: 2024-10-12
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2072-6694/14/9/2259
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Cancers. 14 (9): 2259-
APA: Meler-Claramonte, Carla; Aviles-Jurado, Francesc Xavier; Vilaseca, Isabel; Terra, Ximena; Bragado, Paloma; Fuster, Gemma; Leon Vintro, Xavier; Camacho (2022). Semaphorin-3F/Neuropilin-2 Transcriptional Expression as a Predictive Biomarker of Occult Lymph Node Metastases in HNSCC. Cancers, 14(9), 2259-. DOI: 10.3390/cancers14092259
Article's DOI: 10.3390/cancers14092259
Entity: Universitat Rovira i Virgili
Journal publication year: 2022
Publication Type: Journal Publications
Repositori URV