Author, as appears in the article.: Corba A; Sierra AF; Blondeau P; Giussani B; Riu J; Ballester P; Andrade FJ
Department: Química Analítica i Química Orgànica
URV's Author/s: Riu Rusell, Jordi
Keywords: Membrane electrodes sulfate sensors selective electrode
Abstract: Systematic errors in the calix [4] pyrrole-based potentiometric detection of creatinine have been observed in heavy smokers. This work further characterizes the interactions between the nicotinium cation and the cavitand as well as the resulting interference produced during the potentiometric detection. It is found that the nicotinium cation binds the electronic rich aromatic cavity defined by the pyrrole rings of the receptor's cone conformation with an estimated binding constant higher than 10−4 M−1 in methylene chloride. On the other hand, the creatininium cation is preferentially included in the hydrophobic aromatic cavity of the ionophore by establishing hydrogen bond interactions with the pyrrole NHs groups. Potentiometric calibrations confirmed the detection of the nicotinium cation at neutral and acidic pH, respectively. Due to the lower pka of creatinine, a methodology to quantify creatinine in presence of nicotine by using an array of three sensors at two pH values is proposed. A partial least squares regression was performed and reported recoveries of 103% with a standard deviation of 20%. The improved determination of creatinine was therefore discussed. This approach represents a step forward in the development of effective approaches to improve the measurement of creatinine in decentralized settings.
Thematic Areas: Zootecnia / recursos pesqueiros Spectroscopy Saúde coletiva Química Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Geociências General medicine General chemistry Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Engenharias i Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, analytical Chemistry (miscellaneous) Biotecnología Biodiversidade Biochemistry Astronomia / física Analytical chemistry Administração pública e de empresas, ciências contábeis e turismo
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: jordi.riu@urv.cat
Author identifier: 0000-0001-5823-9223
Record's date: 2024-09-07
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.sciencedirect.com/science/article/pii/S0039914022002697
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Talanta. 246 123473-
APA: Corba A; Sierra AF; Blondeau P; Giussani B; Riu J; Ballester P; Andrade FJ (2022). Potentiometric detection of creatinine in the presence of nicotine: Molecular recognition, sensing and quantification through multivariate regression. Talanta, 246(), 123473-. DOI: 10.1016/j.talanta.2022.123473
Article's DOI: 10.1016/j.talanta.2022.123473
Entity: Universitat Rovira i Virgili
Journal publication year: 2022
Publication Type: Journal Publications