Author, as appears in the article.: Goni, L; Razquin, C; Toledo, E; Guasch-Ferre, M; Clish, CB; Babio, N; Wittenbecher, C; Atzeni, A; Li, J; Liang, LM; Dennis, C; Alonso-Gomez, A; Fito, M; Corella, D; Gomez-Gracia, E; Estruch, R; Fiol, M; Lapetra, J; Serra-Majem, L; Ros, E; Aros, F; Salas-Salvado, J; Hu, FB; Martinez-Gonzalez, MA; Ruiz-Canela, M
Department: Bioquímica i Biotecnologia
URV's Author/s: Atzeni, Alessandro / Babio Sánchez, Nancy Elvira / Salas Salvadó, Jorge
Keywords: Metabolomics Mediterranean diet Heart failure Case-control Atrial fibrillation Asymmetric dimethylarginine adma Arginine catabolism metabolites validation plasma physical-activity questionnaire outcomes nitric-oxide metabolomics mediterranean diet liver-enzymes heart failure disease diagnosis case-control burden atrial fibrillation
Abstract: Arginine-derived metabolites are involved in oxidative and inflammatory processes related with endothelial function and cardiovascular risk.To prospectively examine the associations of arginine catabolism metabolites with the risk of atrial fibrillation (AF) or heart failure (HF), and to evaluate the potential modification of these associations through Mediterranean diet (MedDiet) interventions in a large primary prevention trial.Two nested matched case-control studies were designed within the PREDIMED trial. Five hundred and nine incident cases and 547 matched controls for the AF case-control study, and 326 cases and 402 matched controls for the HF case-control study participants were selected using incidence density sampling. Fasting blood samples were collected at baseline and arginine catabolism metabolites were measured using liquid chromatography tandem mass spectrometry. Multivariable conditional logistic regression models were applied to test the associations between the metabolites and incident AF or HF. Interactions between metabolites and intervention groups (MedDiet groups vs control group) were analyzed with the likelihood ratio test.Inverse associations with incident AF were observed for arginine [OR per 1 SD (95% CI): 0.83 (0.73, 0.94)]) and homoarginine [0.87 (0.76, 0.98)], whereas positive associations were found for the asymmetric dimethylarginine/symmetric dimethylarginine ratio (ADMA/SDMA) [1.15 (1.01, 1.31)] and citrulline [1.19 (1.01, 1.39)]. For HF, inverse associations were found for arginine [0.82 (0.69, 0.97)] and homoarginine [0.81 (0.68, 0.96)], and positive associations for the ADMA/SDMA ratio [1.19 (1.02, 1.41)], N1-acetylspermidine [1.34 (1.12, 1.60)], and diacetylspermine [1.20 (1.02, 1.41)]. In the stratified analysis according to the dietary intervention, the lower HF risk associated with arginine was restricted to participants in the MedDiet groups (p for interaction 0.044).Our results suggest that arginine catabolism metabolites could be involved in AF and HF. Interventions with the MedDiet may contribute to strengthen the inverse association between arginine and the risk of HF.This trial was registered at controlled-trials.com as ISRCTN35739639.© The Author(s) 2022. Published by Oxford University Press on behalf of the American Society for Nutrition.
Thematic Areas: Serviço social Saúde coletiva Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina iii Medicina ii Medicina i General medicine Enfermagem Educação física Ciências biológicas ii Ciência de alimentos Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: alessandro.atzeni@urv.cat alessandro.atzeni@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat
Author identifier: 0000-0002-1804-8606 0000-0002-1804-8606 0000-0003-2700-7459 0000-0003-3527-5277
Record's date: 2024-09-07
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://www.sciencedirect.com/science/article/pii/S000291652200082X?via%3Dihub
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: American Journal Of Clinical Nutrition. 116 (3): 653-662
APA: Goni, L; Razquin, C; Toledo, E; Guasch-Ferre, M; Clish, CB; Babio, N; Wittenbecher, C; Atzeni, A; Li, J; Liang, LM; Dennis, C; Alonso-Gomez, A; Fito, (2022). Arginine catabolism metabolites and atrial fibrillation or heart failure risk: 2 case-control studies within the Prevencion con Dieta Mediterranea (PREDIMED) trial. American Journal Of Clinical Nutrition, 116(3), 653-662. DOI: 10.1093/ajcn/nqac139
Article's DOI: 10.1093/ajcn/nqac139
Entity: Universitat Rovira i Virgili
Journal publication year: 2022
Publication Type: Journal Publications
Repositori URV