Articles producció científica> Bioquímica i Biotecnologia

Proanthocyanidins Restore the Metabolic Diurnal Rhythm of Subcutaneous White Adipose Tissue According to Time-Of-Day Consumption

  • Identification data

    Identifier: imarina:9266835
  • Authors:

    Colom-Pellicer, Marina
    Rodriguez, Romina M.
    Soliz-Rueda, Jorge R.
    de Assis, Leonardo Vinicius Monteiro
    Navarro-Masip, Elia
    Quesada-Vazquez, Sergio
    Escote, Xavier
    Oster, Henrik
    Mulero, Miquel
    Aragones, Gerard
  • Others:

    Author, as appears in the article.: Colom-Pellicer, Marina; Rodriguez, Romina M.; Soliz-Rueda, Jorge R.; de Assis, Leonardo Vinicius Monteiro; Navarro-Masip, Elia; Quesada-Vazquez, Sergio; Escote, Xavier; Oster, Henrik; Mulero, Miquel; Aragones, Gerard;
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Aragonès Bargalló, Gerard / Colom Pellicer, Marina / Mulero Abellán, Miguel / Navarro Masip, Èlia / Rodriguez, Romina Mariel / Soliz Rueda, Jorge Ricardo
    Keywords: Zeitgeber Mice Metabolomics Healthy Glutamine Flavonoids Expression Circadian metabolism Circacompare Chrononutrition Chronobiology Branched-chain Amino-acid-metabolism Acrophase
    Abstract: Consumption of grape seed proanthocyanidin extract (GSPE) has beneficial effects on the functionality of white adipose tissue (WAT). However, although WAT metabolism shows a clear diurnal rhythm, whether GSPE consumption could affect WAT rhythmicity in a time-dependent manner has not been studied. Ninety-six male Fischer rats were fed standard (STD, two groups) or cafeteria (CAF, four groups) diet for 9 weeks (n = 16 each group). From week 6 on, CAF diet animals were supplemented with vehicle or 25 mg GSPE/kg of body weight either at the beginning of the light/rest phase (ZT0) or at the beginning of the dark/active phase (ZT12). The two STD groups were also supplemented with vehicle at ZT0 or ZT12. In week 9, animals were sacrificed at 6 h intervals (n = 4) to analyze the diurnal rhythms of subcutaneous WAT metabolites by nuclear magnetic resonance spectrometry. A total of 45 metabolites were detected, 19 of which presented diurnal rhythms in the STD groups. Although most metabolites became arrhythmic under CAF diet, GSPE consumption at ZT12, but not at ZT0, restored the rhythmicity of 12 metabolites including compounds involved in alanine, aspartate, and glutamate metabolism. These results demonstrate that timed GSPE supplementation may restore, at least partially, the functional dynamics of WAT when it is consumed at the beginning of the active phase. This study opens an innovative strategy for time-dependent polyphenol treatment in obesity and metabolic diseases.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: marina.colom@urv.cat marina.colom@urv.cat marina.colom@urv.cat jorgericardo.soliz@urv.cat rominamariel.rodriguez@urv.cat rominamariel.rodriguez@urv.cat elia.navarro@estudiants.urv.cat elia.navarro@estudiants.urv.cat miquel.mulero@urv.cat gerard.aragones@urv.cat
    Record's date: 2024-07-20
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/2072-6643/14/11/2246
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Nutrients. 14 (11):
    APA: Colom-Pellicer, Marina; Rodriguez, Romina M.; Soliz-Rueda, Jorge R.; de Assis, Leonardo Vinicius Monteiro; Navarro-Masip, Elia; Quesada-Vazquez, Sergi (2022). Proanthocyanidins Restore the Metabolic Diurnal Rhythm of Subcutaneous White Adipose Tissue According to Time-Of-Day Consumption. Nutrients, 14(11), -. DOI: 10.3390/nu14112246
    Article's DOI: 10.3390/nu14112246
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2022
    Publication Type: Journal Publications
  • Keywords:

    Food Science,Nutrition & Dietetics,Nutrition and Dietetics
    Zeitgeber
    Mice
    Metabolomics
    Healthy
    Glutamine
    Flavonoids
    Expression
    Circadian metabolism
    Circacompare
    Chrononutrition
    Chronobiology
    Branched-chain
    Amino-acid-metabolism
    Acrophase
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Planejamento urbano e regional / demografia
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science
    Farmacia
    Engenharias iv
    Engenharias ii
    Enfermagem
    Educação física
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
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