Author, as appears in the article.: Colom-Pellicer, Marina; Rodriguez, Romina M.; Soliz-Rueda, Jorge R.; de Assis, Leonardo Vinicius Monteiro; Navarro-Masip, Elia; Quesada-Vazquez, Sergio; Escote, Xavier; Oster, Henrik; Mulero, Miquel; Aragones, Gerard;
Department: Bioquímica i Biotecnologia
URV's Author/s: Aragonès Bargalló, Gerard / Colom Pellicer, Marina / Mulero Abellán, Miguel / Navarro Masip, Èlia / Rodriguez, Romina Mariel / Soliz Rueda, Jorge Ricardo
Keywords: Zeitgeber Mice Metabolomics Healthy Glutamine Flavonoids Expression Circadian metabolism Circacompare Chrononutrition Chronobiology Branched-chain Amino-acid-metabolism Acrophase
Abstract: Consumption of grape seed proanthocyanidin extract (GSPE) has beneficial effects on the functionality of white adipose tissue (WAT). However, although WAT metabolism shows a clear diurnal rhythm, whether GSPE consumption could affect WAT rhythmicity in a time-dependent manner has not been studied. Ninety-six male Fischer rats were fed standard (STD, two groups) or cafeteria (CAF, four groups) diet for 9 weeks (n = 16 each group). From week 6 on, CAF diet animals were supplemented with vehicle or 25 mg GSPE/kg of body weight either at the beginning of the light/rest phase (ZT0) or at the beginning of the dark/active phase (ZT12). The two STD groups were also supplemented with vehicle at ZT0 or ZT12. In week 9, animals were sacrificed at 6 h intervals (n = 4) to analyze the diurnal rhythms of subcutaneous WAT metabolites by nuclear magnetic resonance spectrometry. A total of 45 metabolites were detected, 19 of which presented diurnal rhythms in the STD groups. Although most metabolites became arrhythmic under CAF diet, GSPE consumption at ZT12, but not at ZT0, restored the rhythmicity of 12 metabolites including compounds involved in alanine, aspartate, and glutamate metabolism. These results demonstrate that timed GSPE supplementation may restore, at least partially, the functional dynamics of WAT when it is consumed at the beginning of the active phase. This study opens an innovative strategy for time-dependent polyphenol treatment in obesity and metabolic diseases.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: marina.colom@urv.cat marina.colom@urv.cat marina.colom@urv.cat jorgericardo.soliz@urv.cat rominamariel.rodriguez@urv.cat rominamariel.rodriguez@urv.cat elia.navarro@estudiants.urv.cat elia.navarro@estudiants.urv.cat miquel.mulero@urv.cat gerard.aragones@urv.cat
Record's date: 2024-09-07
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2072-6643/14/11/2246
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Nutrients. 14 (11):
APA: Colom-Pellicer, Marina; Rodriguez, Romina M.; Soliz-Rueda, Jorge R.; de Assis, Leonardo Vinicius Monteiro; Navarro-Masip, Elia; Quesada-Vazquez, Sergi (2022). Proanthocyanidins Restore the Metabolic Diurnal Rhythm of Subcutaneous White Adipose Tissue According to Time-Of-Day Consumption. Nutrients, 14(11), -. DOI: 10.3390/nu14112246
Article's DOI: 10.3390/nu14112246
Entity: Universitat Rovira i Virgili
Journal publication year: 2022
Publication Type: Journal Publications