Author, as appears in the article.: Peña KB; Riu F; Hernandez A; Guilarte C; Badia J; Parada D
Department: Ciències Mèdiques Bàsiques
URV's Author/s: Parada Dominguez, David / Peña Gonzalez, Karla Beatriz / Riu Ferrando, Francisco Pedro
Keywords: atypia bladder cancer carcinoma cytology dna management urothelial Accuracy Atypia Bladder Cancer Cytology Dna Methylation Urothelial
Abstract: Urothelial bladder cancer is a heterogeneous disease and one of the most common cancers worldwide. Bladder cancer ranges from low-grade tumors that recur and require long-term invasive surveillance to high-grade tumors with high mortality. After the initial contemporary treatment in non-muscle invasive bladder cancer, recurrence and progression rates remain high. Follow-up of these patients involves the use of cystoscopies, cytology, and imaging of the upper urinary tract in selected patients. However, in this context, both cystoscopy and cytology have limitations. In the follow-up of bladder cancer, the finding of urothelial cells with abnormal cytological characteristics is common. The main objective of our study was to evaluate the usefulness of a urine DNA methylation test in patients with urothelial bladder cancer under follow-up and a cytological finding of urothelial cell atypia. In addition, we analyzed the relationship between the urine DNA methylation test, urine cytology, and subsequent cystoscopy study. It was a prospective and descriptive cohort study conducted on patients presenting with non-muscle invasive urothelial carcinoma between 1 January 2018 and 31 May 2022. A voided urine sample and a DNA methylation test was extracted from each patient. A total of 70 patients, 58 male and 12 female, with a median age of 70.03 years were studied. High-grade urothelial carcinoma was the main histopathological diagnosis. Of the cytologies, 41.46% were cataloged as atypical urothelial cells. The DNA methylation test was positive in 17 urine samples, 51 were negative and 2 were invalid. We demonstrated the usefulness of a DNA methylation test in the follow-up of patients diagnosed with urothelial carcinoma. The methylation test also helps to diagnose urothelial cell atypia.
Thematic Areas: Medicine (all) Medicine (miscellaneous) Medicine, general & internal
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: josepmaria.badia@urv.cat josepmaria.badia@urv.cat anabeatriz.hernandez@urv.cat josepmaria.badia@urv.cat franciscopedro.riu@urv.cat david.parada@urv.cat karlabeatriz.pena@urv.cat
Author identifier: 0000-0002-8110-9328
Record's date: 2024-01-13
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2077-0383/11/13/3855
Papper original source: Journal Of Clinical Medicine. 11 (13):
APA: Peña KB; Riu F; Hernandez A; Guilarte C; Badia J; Parada D (2022). Usefulness of the Urine Methylation Test (Bladder EpiCheck®) in Follow-Up Patients with Non-Muscle Invasive Bladder Cancer and Cytological Diagnosis of Atypical Urothelial Cells—An Institutional Study. Journal Of Clinical Medicine, 11(13), -. DOI: 10.3390/jcm11133855
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Article's DOI: 10.3390/jcm11133855
Entity: Universitat Rovira i Virgili
Journal publication year: 2022
Publication Type: Journal Publications
Repositori URV