Articles producció científica> Medicina i Cirurgia

Risk factors for metabolic syndrome in individuals with recent-onset psychosis at disease onset and after 1-year follow-up

  • Identification data

    Identifier: imarina:9271524
  • Authors:

    Alonso Y
    Miralles C
    Algora MJ
    Valiente-Pallejà A
    Sánchez-Gistau V
    Muntané G
    Labad J
    Vilella E
    Martorell L
    Scientific Reports
    10.1038/s41598-022-15479-x
    Scientific Reports. 12 (1):
  • Others:

    Author, as appears in the article.: Alonso Y; Miralles C; Algora MJ; Valiente-Pallejà A; Sánchez-Gistau V; Muntané G; Labad J; Vilella E; Martorell L
    Department: Medicina i Cirurgia
    URV's Author/s: Alonso Perez, Maria Yolanda / Martorell Bonet, Lourdes / Miralles Ibiza, Maria Carmen / Muntané Medina, Gerard / Sánchez Gistau, Vanessa / Valiente Pallejà, Alba / Vilella Cuadrada, Elisabet
    Keywords: 1st-episode schizophrenia-patients validation spectrum disorders spanish version sex prevalence physical-activity mental states cardiovascular risk cardiometabolic risk
    Abstract: Metabolic syndrome (MetS) is a cluster of parameters encompassing the most dangerous heart attack risk factors, associated with increased morbidity and mortality. It is highly prevalent in recent-onset psychosis (ROP) patients. In this pilot study, we evaluated MetS parameters (fasting glucose, high-density lipoprotein (HDL) cholesterol (HDL-c), fasting triglycerides, waist circumference, and systolic and diastolic blood pressure), clinical symptoms, pharmacological treatment, lifestyle, and inflammatory markers in 69 patients with ROP and 61 healthy controls (HCs). At baseline, waist circumference (p = 0.005) and fasting triglycerides (p = 0.007) were higher in patients with ROP than in HCs. At the 1-year follow-up, patients showed clinical improvement, with a reduction in the positive and negative syndrome scale (PANSS) score (p < 0.001), dietary intake (p = 0.001), and antipsychotic medication dose (p < 0.001); however, fasting glucose (p = 0.011), HDL-c (p = 0.013) and waist circumference worsened (p < 0.001). We identified sex, age, BMI, dietary intake, physical activity, daily tobacco use, daily cannabis use, and antipsychotic doses as risk factors contributing to baseline MetS parameters. After 1-year follow-up, those factors plus the PANSS and Calgary Depression Scale for Schizophrenia (CDSS) scores were associated with MetS parameters. Further studies are needed to understand the contributions of the studied risk factors in patients with ROP at onset and during disease progression.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Letras / linguística Interdisciplinar Geografía Geociências Farmacia Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: alba.valiente@urv.cat gerard.muntane@urv.cat vanessa.sanchezg@urv.cat lourdes.martorell@urv.cat elisabet.vilella@urv.cat mariayolanda.alonso@urv.cat mariacarmen.miralles@estudiants.urv.cat
    Author identifier: 0000-0003-4999-2197 0000-0002-1887-5919 0000-0001-9784-0636
    Record's date: 2024-07-20
    Papper version: info:eu-repo/semantics/publishedVersion
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Scientific Reports. 12 (1):
    APA: Alonso Y; Miralles C; Algora MJ; Valiente-Pallejà A; Sánchez-Gistau V; Muntané G; Labad J; Vilella E; Martorell L (2022). Risk factors for metabolic syndrome in individuals with recent-onset psychosis at disease onset and after 1-year follow-up. Scientific Reports, 12(1), -. DOI: 10.1038/s41598-022-15479-x
    Article's DOI: 10.1038/s41598-022-15479-x
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2022
    Publication Type: Journal Publications
  • Keywords:

    Multidisciplinary,Multidisciplinary Sciences
    1st-episode schizophrenia-patients
    validation
    spectrum disorders
    spanish version
    sex
    prevalence
    physical-activity
    mental states
    cardiovascular risk
    cardiometabolic risk
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Odontología
    Nutrição
    Multidisciplinary sciences
    Multidisciplinary
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Matemática / probabilidade e estatística
    Letras / linguística
    Interdisciplinar
    Geografía
    Geociências
    Farmacia
    Engenharias iv
    Engenharias iii
    Engenharias ii
    Enfermagem
    Educação física
    Educação
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Ciência da computação
    Biotecnología
    Biodiversidade
    Astronomia / física
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