Author, as appears in the article.: Morales-Serna, Jose Antonio; Boutureira, Omar; Diaz, Yolanda; Matheu, M Isabel; Castillon, Sergio
Department: Química Analítica i Química Orgànica
URV's Author/s: Boutureira Martín, Omar / Castillón Miranda, Sergio / Díaz Giménez, María Yolanda / Matheu Malpartida, María Isabel
Keywords: Unclassified drug Sphingosines Sphingosine derivative Sphingosine Signal transduction Review Priority journal Phytosphintgosines Phytosphintgosine Pathogens Oligosaccharides Molecular conformation Modulation transfer function Models, molecular Lipids Glycosylation Glycosphingolipids Glycosphingolipid Glycosides Eukaryote Eukaryota Ceramides Ceramide derivative Cell proliferation Cell membranes Cell membrane Cell interaction Cell differentiation Carbohydrates Carbohydrate synthesis Carbohydrate conformation Carbohydrate analysis Carbohydrate Beta glycosyl sphingosine Amides Alpha glycosyl sphingosine
Abstract: Glycosphingolipids (GSLs) are ubiquitous components of eukaryotic cell membranes. They are highly bioactive and are involved in many aspects of cell signalling like cell-cell interaction, cell-substratum interaction and cell-pathogen interaction. GSLs also are involved in the modulation of signal transduction, resulting in regulation of cell proliferation and differentiation. The biological importance and complexity of these compounds afford many opportunities to prepare synthetic analogues for studies of their metabolism in intra- and intercellular processes. This review focuses on recent contributions in the synthesis of GSLs, highlighting improvements in glycosylation reactions leading to ? and ? glycosyl sphingosines and ceramides and related compounds. Literature from 2000 to the present is covered. The glycosylation reactions leading to the synthesis of GSLs are classified in function of the configuration of the created glycosidic bond (? or ?) and of the acceptor used, either azido-sphingosine or ceramide. © 2007 Elsevier Ltd. All rights reserved.
Thematic Areas: Química Organic chemistry Odontología Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Farmacia Ensino Engenharias iii Engenharias ii Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Chemistry, organic Chemistry, applied Biotecnología Biodiversidade Biochemistry & molecular biology Biochemistry Analytical chemistry
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: omar.boutureira@urv.cat yolanda.diaz@urv.cat maribel.matheu@urv.cat sergio.castillon@urv.cat
Author identifier: 0000-0002-0768-8309 0000-0001-5567-8108 0000-0001-5216-9260 0000-0002-0690-7549
Record's date: 2024-11-30
Paper version: info:eu-repo/semantics/acceptedVersion
Paper original source: Carbohydrate Research. 342 (12-13): 1595-1612
APA: Morales-Serna, Jose Antonio; Boutureira, Omar; Diaz, Yolanda; Matheu, M Isabel; Castillon, Sergio (2007). Recent advances in the glycosylation of sphingosines and ceramides. Carbohydrate Research, 342(12-13), 1595-1612. DOI: 10.1016/j.carres.2007.03.028
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Entity: Universitat Rovira i Virgili
Journal publication year: 2007
Publication Type: Journal Publications
Repositori URV