Articles producció científica> Ciències Mèdiques Bàsiques

Fiber-like Action of d-Fagomine on the Gut Microbiota and Body Weight of Healthy Rats

  • Identification data

    Identifier: imarina:9286885
    Authors:
    Ramos-Romero SPonomarenko JAmézqueta SHereu MMiralles-Pérez BRomeu MMéndez LMedina ITorres JL
    Abstract:
    The goal of this work is to explore if the changes induced by d-fagomine in the gut microbiota are compatible with its effect on body weight and inflammation markers in rats. Methods: Sprague Dawley rats were fed a standard diet supplemented with d-fagomine (or not, for comparison) for 6 months. The variables measured were body weight, plasma mediators of inflammation (hydroxyeicosatetraenoic acids, leukotriene B4, and IL-6), and the concentration of acetic acid in feces and plasma. The composition and diversities of microbiota in cecal content and feces were estimated using 16S rRNA metabarcoding and high-throughput sequencing. We found that after just 6 weeks of intake d-fagomine significantly reduced body weight gain, increased the plasma acetate concentration, and reduced the plasma concentration of the pro-inflammatory biomarkers' leukotriene B4, interleukin 6 and 12 hydroxyeicosatetraenoic acids. These changes were associated with a significantly increased prevalence of Bacteroides and Prevotella feces and increased Bacteroides, Prevotella, Clostridium, and Dysgonomonas while reducing Anaerofilum, Blautia, and Oribacterium in cecal content. In conclusion, d-fagomine induced changes in the composition and diversity of gut microbiota similar to those elicited by dietary fiber and compatible with its anti-inflammatory and body-weight-reducing effects.
  • Others:

    Author, as appears in the article.: Ramos-Romero S; Ponomarenko J; Amézqueta S; Hereu M; Miralles-Pérez B; Romeu M; Méndez L; Medina I; Torres JL
    Department: Ciències Mèdiques Bàsiques
    URV's Author/s: Miralles Pérez, Bernat / Romeu Ferran, Marta
    Keywords: Inflammation Iminosugar Iminocyclitol Gut microbiota Dietary fiber D-fagomine Body weight profiles polysaccharide utilization obesity inflammation improvement impact iminosugar iminocyclitol gut microbiota glucose fatty-acids d-fagomine
    Abstract: The goal of this work is to explore if the changes induced by d-fagomine in the gut microbiota are compatible with its effect on body weight and inflammation markers in rats. Methods: Sprague Dawley rats were fed a standard diet supplemented with d-fagomine (or not, for comparison) for 6 months. The variables measured were body weight, plasma mediators of inflammation (hydroxyeicosatetraenoic acids, leukotriene B4, and IL-6), and the concentration of acetic acid in feces and plasma. The composition and diversities of microbiota in cecal content and feces were estimated using 16S rRNA metabarcoding and high-throughput sequencing. We found that after just 6 weeks of intake d-fagomine significantly reduced body weight gain, increased the plasma acetate concentration, and reduced the plasma concentration of the pro-inflammatory biomarkers' leukotriene B4, interleukin 6 and 12 hydroxyeicosatetraenoic acids. These changes were associated with a significantly increased prevalence of Bacteroides and Prevotella feces and increased Bacteroides, Prevotella, Clostridium, and Dysgonomonas while reducing Anaerofilum, Blautia, and Oribacterium in cecal content. In conclusion, d-fagomine induced changes in the composition and diversity of gut microbiota similar to those elicited by dietary fiber and compatible with its anti-inflammatory and body-weight-reducing effects.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: bmirallesperez@gmail.com marta.romeu@urv.cat
    Author identifier: 0000-0003-1294-7069 0000-0002-2131-1858
    Record's date: 2024-10-26
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/2072-6643/14/21/4656
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Nutrients. 14 (21):
    APA: Ramos-Romero S; Ponomarenko J; Amézqueta S; Hereu M; Miralles-Pérez B; Romeu M; Méndez L; Medina I; Torres JL (2022). Fiber-like Action of d-Fagomine on the Gut Microbiota and Body Weight of Healthy Rats. Nutrients, 14(21), -. DOI: 10.3390/nu14214656
    Article's DOI: 10.3390/nu14214656
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2022
    Publication Type: Journal Publications
  • Keywords:

    Food Science,Nutrition & Dietetics,Nutrition and Dietetics
    Inflammation
    Iminosugar
    Iminocyclitol
    Gut microbiota
    Dietary fiber
    D-fagomine
    Body weight
    profiles
    polysaccharide utilization
    obesity
    inflammation
    improvement
    impact
    iminosugar
    iminocyclitol
    gut microbiota
    glucose
    fatty-acids
    d-fagomine
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Planejamento urbano e regional / demografia
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science
    Farmacia
    Engenharias iv
    Engenharias ii
    Enfermagem
    Educação física
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
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