Articles producció científica> Medicina i Cirurgia

Pharmacological interventions for preventing complications in patients with idiopathic hypercalciuria: A systematic review

  • Identification data

    Identifier: imarina:9287383
    Authors:
    Ferre, NataliaParada, EsterBalaguer, AlbertFeliu, AlbertRoque-Figuls, MartaFranco, Juan Victor A.Escribano, Joaquin
    Abstract:
    Objective: To assess the effects of pharmacological interventions in patients with idiopathic hypercalciuria.Methods: We performed a search of multiple databases, trial registries, grey literature and conference proceedings up to October 2019. We included randomized and quasi-randomized controlled trials that examined any pharmacological intervention for preventing complications of idiopathic hypercalciuria (given for at least four months and six of follow-up). The primary outcomes were stone-free patients, urinary symptoms and severe adverse events.Results: We included five RCTs (n = 446 patients, all adults, 4 in individuals with kidney stones and 1 in postmenopausal women with osteoporosis). Diuretics were likely to increase the number of stone-free patients (RR 1.61, 95% CI 1.33-1.96, moderate quality of evidence (QoE)); 274 more stone-free patients/1000 patients treated (95% CI: 148-432) and produced a slight decrease in the stone formation rate (mean difference -0.18, 95% CI -0.30 to -0.06, low QoE); 180 fewer stones/year/1000 patients treated (95% CI: 300 r to 60). No data on urinary symptoms were reported. The association between diuretic use and severe adverse events was uncertain (RR 5.00, 95% CI 0.60-41.88, very low QoE); 4 more severe adverse events/1000 patients treated (95% CI: 0 fewer to 39 more).Conclusions: The addition of diuretics to a normal or modified diet probably reduces the number of stone recurrences and may decrease the stone formation rate. It is uncertain whether diuretics increase the occurrence of severe adverse events. There were no studies investigating other outcomes or in children. (C) 2021 Sociedad Espanola de Nefrologia. Published by Elsevier Espana, S.L.U.
  • Others:

    Author, as appears in the article.: Ferre, Natalia; Parada, Ester; Balaguer, Albert; Feliu, Albert; Roque-Figuls, Marta; Franco, Juan Victor A.; Escribano, Joaquin;
    Department: Medicina i Cirurgia
    URV's Author/s: Escribano Subías, Joaquín / Feliu Rovira, Albert / Ferre Pallas, Natalia / Parada Ricart, Esther
    Keywords: Urolithiasis Urine calcium Systematic review Risk Recurrent nephrolithiasis Mass Kidney stones Indapamide Idiopathic hypercalciuria Diuretics Citrate Children Bone-mineral density Alendronate
    Abstract: Objective: To assess the effects of pharmacological interventions in patients with idiopathic hypercalciuria.Methods: We performed a search of multiple databases, trial registries, grey literature and conference proceedings up to October 2019. We included randomized and quasi-randomized controlled trials that examined any pharmacological intervention for preventing complications of idiopathic hypercalciuria (given for at least four months and six of follow-up). The primary outcomes were stone-free patients, urinary symptoms and severe adverse events.Results: We included five RCTs (n = 446 patients, all adults, 4 in individuals with kidney stones and 1 in postmenopausal women with osteoporosis). Diuretics were likely to increase the number of stone-free patients (RR 1.61, 95% CI 1.33-1.96, moderate quality of evidence (QoE)); 274 more stone-free patients/1000 patients treated (95% CI: 148-432) and produced a slight decrease in the stone formation rate (mean difference -0.18, 95% CI -0.30 to -0.06, low QoE); 180 fewer stones/year/1000 patients treated (95% CI: 300 r to 60). No data on urinary symptoms were reported. The association between diuretic use and severe adverse events was uncertain (RR 5.00, 95% CI 0.60-41.88, very low QoE); 4 more severe adverse events/1000 patients treated (95% CI: 0 fewer to 39 more).Conclusions: The addition of diuretics to a normal or modified diet probably reduces the number of stone recurrences and may decrease the stone formation rate. It is uncertain whether diuretics increase the occurrence of severe adverse events. There were no studies investigating other outcomes or in children. (C) 2021 Sociedad Espanola de Nefrologia. Published by Elsevier Espana, S.L.U.
    Thematic Areas: Urology & nephrology Saúde coletiva Psicología Nephrology Medicine (miscellaneous) Medicine (all) Medicina ii Medicina i General medicine
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: esther.parada@urv.cat albert.feliu@urv.cat natalia.ferre@urv.cat joaquin.escribano@urv.cat
    Author identifier: 0000-0002-2838-1525 0000-0002-5041-459X
    Record's date: 2024-09-07
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/pii/S0211699521001508?via%3Dihub
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Nefrologia. 42 (5): 506-518
    APA: Ferre, Natalia; Parada, Ester; Balaguer, Albert; Feliu, Albert; Roque-Figuls, Marta; Franco, Juan Victor A.; Escribano, Joaquin; (2022). Pharmacological interventions for preventing complications in patients with idiopathic hypercalciuria: A systematic review. Nefrologia, 42(5), 506-518. DOI: 10.1016/j.nefro.2021.04.007
    Article's DOI: 10.1016/j.nefro.2021.04.007
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2022
    Publication Type: Journal Publications
  • Keywords:

    Medicine (Miscellaneous),Nephrology,Urology & Nephrology
    Urolithiasis
    Urine calcium
    Systematic review
    Risk
    Recurrent nephrolithiasis
    Mass
    Kidney stones
    Indapamide
    Idiopathic hypercalciuria
    Diuretics
    Citrate
    Children
    Bone-mineral density
    Alendronate
    Urology & nephrology
    Saúde coletiva
    Psicología
    Nephrology
    Medicine (miscellaneous)
    Medicine (all)
    Medicina ii
    Medicina i
    General medicine
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