Author, as appears in the article.: Alejandra Perez-Vega, Karla; Castaner, Olga; Sanllorente, Albert; Lassale, Camille; Ros, Emilio; Pinto, Xavier; Estruch, Ramon; Salas-Salvado, Jordi; Corella, Dolores; Alonso-Gomez, Angel M.; Serra-Majem, Lluis; Razquin, Cristina; Fiol, Miquel; Lapetra, Jose; Gomez-Gracia, Enrique; Tinahones, Francisco J.; Hernaez, Alvaro; Fito, Montserrat;
Department: Bioquímica i Biotecnologia
URV's Author/s: Salas Salvadó, Jorge
Keywords: Very low-density lipoprotein Validity Triglycerides Triglyceride-rich lipoproteins Resistance Randomized controlled trial Population Men Mediterranean diet Hypertriglyceridemia High-cardiovascular-risk Energy-reduced diet Apolipoprotein c Adherence
Abstract: ScopeSome very-low density lipoprotein (VLDL) properties may render them more pro-atherogenic. We aimed to assess whether a Mediterranean diet (MedDiet) or an energy-reduced MedDiet with increased physical activity improves them. Methods and resultsIn a sample of the PREvencion con DIeta MEDiterranea (PREDIMED) study, a 1-year intervention with MedDiet with extra-virgin olive oil (n = 89) or nuts (MedDiet-Nuts; n = 79) is compared with a low-fat diet (n = 90). In the PREDIMED-Plus study, a 1-year intervention with energy-reduced MedDiet and physical activity (n = 103) is compared with an ad libitum MedDiet (n = 101). VLDL levels of apolipoprotein C-I, C-III, triglycerides, and cholesterol; the apolipoprotein E-/C-I ratio; and VLDL ex-vivo triglyceride transfer are measured. In PREDIMED participants in both MedDiet groups combined, VLDL apolipoprotein C-III levels are nominally reduced (-0.023 SD units, 95% CI -0.44 to -0.014, p = 0.037). VLDL triglyceride transfer is nominally increased in the MedDiet-Nuts group (+0.39 SD units, 95% CI 0.012-0.78, p = 0.045). In PREDIMED-Plus, no inter-group differences are detected. ConclusionsIn older adults at high cardiovascular risk, MedDiet is associated with lower VLDL atherogenicity versus a low-fat diet. No differences are seen after an energy-reduced MedDiet with physical activity.
Thematic Areas: Saúde coletiva Química Nutrição Medicina veterinaria Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biotechnology Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: jordi.salas@urv.cat
Author identifier: 0000-0003-2700-7459
Record's date: 2024-08-03
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://onlinelibrary.wiley.com/doi/10.1002/mnfr.202200338
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Molecular Nutrition & Food Research. 67 (1): 2200338-
APA: Alejandra Perez-Vega, Karla; Castaner, Olga; Sanllorente, Albert; Lassale, Camille; Ros, Emilio; Pinto, Xavier; Estruch, Ramon; Salas-Salvado, Jordi; (2023). Mediterranean Diet, Energy Restriction, Physical Activity, and Atherogenicity of Very-Low Density Lipoproteins: Findings from Two Randomized Controlled Trials. Molecular Nutrition & Food Research, 67(1), 2200338-. DOI: 10.1002/mnfr.202200338
Article's DOI: 10.1002/mnfr.202200338
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications
Repositori URV