Author, as appears in the article.: Fernández-Miranda, I; Pedrosa, L; Llanos, M; Franco, FF; Gómez, S; Martín-Acosta, P; García-Arroyo, FR; Gumá, J; Horcajo, B; Ballesteros, AK; Gálvez, L; Martínez, N; Marín, M; Sequero, S; Navarro, M; Yanguas-Casás, N; Calvo, V; Rueda-Domínguez, A; Provencio, M; Sánchez-Beato, M
Department: Medicina i Cirurgia
URV's Author/s: Gumà Padró, José
Keywords: B-cell lymphoma vincristine transformation prognostic value hodgkin high-risk gene-mutations doxorubicin cyclophosphamide 1st-line immunochemotherapy
Abstract: Follicular lymphoma (FL) is the most frequent indolent non-Hodgkin lymphoma. Around 20% of patients suffer early disease progression within 24 months (POD24) of diagnosis. This study examined the significance of circulating tumor DNA (ctDNA) in predicting response to therapy and POD24 in patients with FL.We collected 100 plasma samples, before and during the treatment, from 36 patients with FL prospectively enrolled in 8 Spanish hospitals. They were treated with a chemotherapy-rituximab regimen and followed up for a median of 3.43 years. We performed targeted deep sequencing in cell-free DNA (cfDNA) and tumor genomic DNA from 31 diagnostic biopsy samples.Of the alterations detected in the diagnostic tissue samples, 73% (300/411) were also identified in basal cfDNA. The mean numbers of alterations per basal cfDNA sample in patients who suffered progression of disease within 24 months (POD24-pos) or did not achieve complete response (non-CR) were significantly higher than in POD24-neg or CR patients (unpaired samples t test, P = 0.0001 and 0.001, respectively). Pretreatment ctDNA levels, as haploid genome equivalents per milliliter of plasma, were higher in patients without CR (P = 0.02) and in POD24-pos patients compared with POD24-neg patients (P < 0.001). Dynamic analysis showed that ctDNA levels decreased dramatically after treatment, although the reduction was more significant in patients with CR and POD24-neg patients.Basal ctDNA levels are associated with the risk of early progression and response to treatment in FL. cfDNA monitoring and genotyping during treatment and follow-up predict response to treatment and early progression.©2022 The Authors; Published by the American Association for Cancer Research.
Thematic Areas: Saúde coletiva Química Oncology Odontología Nutrição Medicine (all) Medicina iii Medicina ii Medicina i General medicine Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência da computação Cancer research Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: jose.guma@urv.cat
Author identifier: 0000-0001-7541-9832
Record's date: 2024-08-03
Papper version: info:eu-repo/semantics/publishedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Clinical Cancer Research. 29 (1): 209-220
APA: Fernández-Miranda, I; Pedrosa, L; Llanos, M; Franco, FF; Gómez, S; Martín-Acosta, P; García-Arroyo, FR; Gumá, J; Horcajo, B; Ballesteros, AK; Gálvez, (2023). Monitoring of Circulating Tumor DNA Predicts Response to Treatment and Early Progression in Follicular Lymphoma: Results of a Prospective Pilot Study. Clinical Cancer Research, 29(1), 209-220. DOI: 10.1158/1078-0432.ccr-22-1654
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications
Repositori URV