Articles producció científica> Ciències Mèdiques Bàsiques

Serotypes and Clonal Composition of Streptococcus pneumoniae Isolates Causing IPD in Children and Adults in Catalonia before 2013 to 2015 and after 2017 to 2019 Systematic Introduction of PCV13

  • Identification data

    Identifier: imarina:9289936
    Handle: https://hdl.handle.net/20.500.11797/imarina9289936
    Authors:
    Redin, A.Ciruela, P.de Sevilla, M. F.Gomez-Bertomeu, F.Gonzalez-Peris, S.Benitez, M. A.Trujillo, G.Diaz, A.Jou, E.Izquierdo, C.Perez-Moreno, M. O.Moraga-Llop, F.Olsina, M.Vinado, B.Sanfeliu, E.Garcia, A.Gonzalez-di Lauro, S.Garcia-Garcia, J. J.Dominguez, A.Sa-Leao, R.Munoz-Almagro, C.Catalan Study Grp Invasive Pneumoc
    Abstract:
    The goal of this study was to investigate the distribution of serotypes and clonal composition of Streptococcus pneumoniae isolates causing invasive pneumococcal disease (IPD) in Catalonia, before and after systematic introduction of PCV13. Pneumococcal strains isolated from normally sterile sites obtained from patients of all ages with IPD received between 2013 and 2019 from 25 health centers of Catalonia were included. Two study periods were defined: presystematic vaccination period (2013 and 2015) and systematic vaccination period (SVP) (2017 to 2019). A total of 2,303 isolates were analyzed. In the SVP, there was a significant decrease in the incidence of IPD cases in children 5 to 17 years old (relative risk [RR] 0.61; 95% confidence interval [CI] 0.38 to 0.99), while there was a significant increase in the incidence of IPD cases in 18- to 64-year-old adults (RR 1.33; 95% CI 1.16 to 1.52) and adults over 65 years old (RR 1.23; 95% CI 1.09 to 1.38). Serotype 8 was the major emerging serotype in all age groups except in 5- to 17-year-old children. In children younger than 5 years old, the main serotypes in SVP were 24F, 15A, and 3, while in adults older than 65 years they were serotypes 3, 8, and 12F. A significant decrease in the proportions of clonal complexes CC156, CC191, and ST306 and an increase in those of CC180, CC53, and CC404 were observed. A steady decrease in the incidence of IPD caused by PCV13 serotypes indicates the importance and impact of systematic vaccination. The increase of non-PCV13 serotypes highlights the need to expand serotype coverage in future vaccines and rethink vaccination programs for older adults.IMPORTANCE We found that with the incorporation of the PCV13 vaccine, the numbers of IPD cases caused by serotypes included in this vaccine

  • Others:

    Author, as appears in the article.: Redin, A.; Ciruela, P.; de Sevilla, M. F.; Gomez-Bertomeu, F.; Gonzalez-Peris, S.; Benitez, M. A.; Trujillo, G.; Diaz, A.; Jou, E.; Izquierdo, C.; Perez-Moreno, M. O.; Moraga-Llop, F.; Olsina, M.; Vinado, B.; Sanfeliu, E.; Garcia, A.; Gonzalez-di Lauro, S.; Garcia-Garcia, J. J.; Dominguez, A.; Sa-Leao, R.; Munoz-Almagro, C.;Catalan Study Grp Invasive Pneumoc
    Department: Ciències Mèdiques Bàsiques
    URV's Author/s: Gomez Bertomeu, Frederic-Francesc
    Keywords: Susceptibility Streptococcus pneumoniae Serotypes Safety Replacement Portugal Pneumococcal conjugate vaccines Patterns Invasive pneumococcal disease England Emergence Efficacy Clones 13-valent conjugate vaccine
    Abstract: The goal of this study was to investigate the distribution of serotypes and clonal composition of Streptococcus pneumoniae isolates causing invasive pneumococcal disease (IPD) in Catalonia, before and after systematic introduction of PCV13. Pneumococcal strains isolated from normally sterile sites obtained from patients of all ages with IPD received between 2013 and 2019 from 25 health centers of Catalonia were included. Two study periods were defined: presystematic vaccination period (2013 and 2015) and systematic vaccination period (SVP) (2017 to 2019). A total of 2,303 isolates were analyzed. In the SVP, there was a significant decrease in the incidence of IPD cases in children 5 to 17 years old (relative risk [RR] 0.61; 95% confidence interval [CI] 0.38 to 0.99), while there was a significant increase in the incidence of IPD cases in 18- to 64-year-old adults (RR 1.33; 95% CI 1.16 to 1.52) and adults over 65 years old (RR 1.23; 95% CI 1.09 to 1.38). Serotype 8 was the major emerging serotype in all age groups except in 5- to 17-year-old children. In children younger than 5 years old, the main serotypes in SVP were 24F, 15A, and 3, while in adults older than 65 years they were serotypes 3, 8, and 12F. A significant decrease in the proportions of clonal complexes CC156, CC191, and ST306 and an increase in those of CC180, CC53, and CC404 were observed. A steady decrease in the incidence of IPD caused by PCV13 serotypes indicates the importance and impact of systematic vaccination. The increase of non-PCV13 serotypes highlights the need to expand serotype coverage in future vaccines and rethink vaccination programs for older adults.IMPORTANCE We found that with the incorporation of the PCV13 vaccine, the numbers of IPD cases caused by serotypes included in this vaccine decreased in all of the age groups. Still, there was an unforeseen increase of the serotypes not included in this vaccine causing IPD, especially in the >65-year-old group. Moreover, a significant increase of serotype 3 included in the vaccine has been observed; this event has been reported by other researchers. These facts call for the incorporation of more serotypes in future vaccines and a more thorough surveillance of the dynamics of this microorganism.
    Thematic Areas: Physiology Microbiology (medical) Microbiology Infectious diseases Immunology and microbiology (miscellaneous) Immunology and microbiology (all) Genetics General medicine General immunology and microbiology Ecology Ciências agrárias i Cell biology
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: frederic-francesc.gomez@urv.cat
    Author identifier: 0000-0002-8039-2889
    Record's date: 2024-07-27
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://journals.asm.org/doi/10.1128/Spectrum.01150-21
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Microbiology Spectrum. 9 (3):
    APA: Redin, A.; Ciruela, P.; de Sevilla, M. F.; Gomez-Bertomeu, F.; Gonzalez-Peris, S.; Benitez, M. A.; Trujillo, G.; Diaz, A.; Jou, E.; Izquierdo, C.; Per (2021). Serotypes and Clonal Composition of Streptococcus pneumoniae Isolates Causing IPD in Children and Adults in Catalonia before 2013 to 2015 and after 2017 to 2019 Systematic Introduction of PCV13. Microbiology Spectrum, 9(3), -. DOI: 10.1128/Spectrum.01150-21
    Article's DOI: 10.1128/Spectrum.01150-21
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2021
    Publication Type: Journal Publications

  • Keywords:

    Cell Biology,Ecology,Genetics,Immunology and Microbiology (Miscellaneous),Infectious Diseases,Microbiology,Microbiology (Medical),Physiology
    Susceptibility
    Streptococcus pneumoniae
    Serotypes
    Safety
    Replacement
    Portugal
    Pneumococcal conjugate vaccines
    Patterns
    Invasive pneumococcal disease
    England
    Emergence
    Efficacy
    Clones
    13-valent conjugate vaccine
    Physiology
    Microbiology (medical)
    Microbiology
    Infectious diseases
    Immunology and microbiology (miscellaneous)
    Immunology and microbiology (all)
    Genetics
    General medicine
    General immunology and microbiology
    Ecology
    Ciências agrárias i
    Cell biology

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