Articles producció científica> Química Física i Inorgànica

Dinuclear Iron Complexes of Iminopyridine-Based Ligands as Selective Cytotoxins for Tumor Cells and Inhibitors of Cancer Cell Migration

  • Identification data

    Identifier: imarina:9290324
    Authors:
    Castro, JessicaBravo, MarlonAlberti, MeritxellMarsal, AnaisJose Alonso-De Gennaro, MariaMartinez-Ferrate, OriolClaver, Carmenvan Leeuwen, Piet W N MRomero, IsabelBenito, AntoniVilanova, Maria
    Abstract:
    A family of dinuclear iron (II) compounds with iminopyridine-based ligands displays selective cytotoxic activity against cancer cell lines. All compounds have IC50 values 2-6 fold lower than that of cisplatin, and 30-90 fold lower than that of carboplatin for the tumor cell lines assayed. Comparing the IC50 values between tumor and non-tumor cell lines, the selectivity indexes range from 3.2 to 34, compound 10, [Fe-2(4)(2)(CH3CN)(4)](BF4)(4), showing the highest selectivity. Those compounds carrying substituents on the iminopyridine ring show the same cytotoxicity as those without substituents. However, the electronic effects of the substituents on position 6 may be important for the cytotoxicity of the complexes, and consequently for their selectivity. All compounds act over DNA, promoting cuts on both strands in the presence of reactive oxygen species. Since compound 10 presented the highest selectivity, its cytotoxic effect was further characterized. It induces apoptosis, affects cell cycle phase distribution in a cell-dependent manner, and its cytotoxic effect is linked to reactive oxygen species generation. In addition, it decreases tumor cell migration, showing potential antimetastatic effects. These properties make compound 10 a good lead antitumor agent among all compounds studied here.
  • Others:

    Author, as appears in the article.: Castro, Jessica; Bravo, Marlon; Alberti, Meritxell; Marsal, Anais; Jose Alonso-De Gennaro, Maria; Martinez-Ferrate, Oriol; Claver, Carmen; van Leeuwen, Piet W N M; Romero, Isabel; Benito, Antoni; Vilanova, Maria
    Department: Química Física i Inorgànica
    URV's Author/s: Claver Cabrero, Maria del Carmen Orosia
    Keywords: Anticancer Apoptosis Cytotoxic mechanism Dinuclear iron (ii) compounds Iminopyridine ligands Inhibition of cell migration Selectivity for tumor cells
    Abstract: A family of dinuclear iron (II) compounds with iminopyridine-based ligands displays selective cytotoxic activity against cancer cell lines. All compounds have IC50 values 2-6 fold lower than that of cisplatin, and 30-90 fold lower than that of carboplatin for the tumor cell lines assayed. Comparing the IC50 values between tumor and non-tumor cell lines, the selectivity indexes range from 3.2 to 34, compound 10, [Fe-2(4)(2)(CH3CN)(4)](BF4)(4), showing the highest selectivity. Those compounds carrying substituents on the iminopyridine ring show the same cytotoxicity as those without substituents. However, the electronic effects of the substituents on position 6 may be important for the cytotoxicity of the complexes, and consequently for their selectivity. All compounds act over DNA, promoting cuts on both strands in the presence of reactive oxygen species. Since compound 10 presented the highest selectivity, its cytotoxic effect was further characterized. It induces apoptosis, affects cell cycle phase distribution in a cell-dependent manner, and its cytotoxic effect is linked to reactive oxygen species generation. In addition, it decreases tumor cell migration, showing potential antimetastatic effects. These properties make compound 10 a good lead antitumor agent among all compounds studied here.
    Thematic Areas: Biotecnología Ciências biológicas i Ciências biológicas ii Ciências biológicas iii Farmacia Medicina ii Pharmaceutical science Pharmacology & pharmacy
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: carmen.claver@urv.cat
    Author identifier: 0000-0002-2518-7401
    Record's date: 2024-10-12
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/1999-4923/14/12/2801
    Papper original source: Pharmaceutics. 14 (12): 2801-
    APA: Castro, Jessica; Bravo, Marlon; Alberti, Meritxell; Marsal, Anais; Jose Alonso-De Gennaro, Maria; Martinez-Ferrate, Oriol; Claver, Carmen; van Leeuwen (2022). Dinuclear Iron Complexes of Iminopyridine-Based Ligands as Selective Cytotoxins for Tumor Cells and Inhibitors of Cancer Cell Migration. Pharmaceutics, 14(12), 2801-. DOI: 10.3390/pharmaceutics14122801
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.3390/pharmaceutics14122801
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2022
    Publication Type: Journal Publications
  • Keywords:

    Pharmaceutical Science,Pharmacology & Pharmacy
    Anticancer
    Apoptosis
    Cytotoxic mechanism
    Dinuclear iron (ii) compounds
    Iminopyridine ligands
    Inhibition of cell migration
    Selectivity for tumor cells
    Biotecnología
    Ciências biológicas i
    Ciências biológicas ii
    Ciências biológicas iii
    Farmacia
    Medicina ii
    Pharmaceutical science
    Pharmacology & pharmacy
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