Author, as appears in the article.: Pavel, MC; Ramirez-Maldonado, E; Pueyo-Périz, E; Memba, R; Merino, S; Geoghegan, J; Jorba, R
Department: Medicina i Cirurgia
URV's Author/s: Jorba Martin, Rosa Maria / Memba Ikuga, Roberto
Keywords: Monoclonal antibodies Molecular biology Follow-up Colorectal cancer liver metastasis
Abstract: There is a clear association between the molecular profile of colorectal cancer liver metastases (CRCLM) and the degree to which aggressive progression of the disease impacts patient survival. However, much of our knowledge of the molecular behaviour of colorectal cancer cells comes from experimental studies with, as yet, limited application in clinical practice. In this article, we review the current advances in the understanding of the molecular behaviour of CRCLM and present possible future therapeutic applications. This review focuses on three important steps in CRCLM development, progression and treatment: (1) the dissemination of malignant cells from primary tumours and the seeding to metastatic sites; (2) the response to modern regimens of chemotherapy; and (3) the possibility of predicting early progression and recurrence patterns by molecular analysis in liquid biopsy.
Thematic Areas: Zootecnia / recursos pesqueiros Spectroscopy Saúde coletiva Química Psicología Physical and theoretical chemistry Organic chemistry Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Inorganic chemistry Geociências Farmacia Engenharias iv Engenharias ii Engenharias i Educação física Computer science applications Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, multidisciplinary Catalysis Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: roberto.memba@urv.cat rosamaria.jorba@urv.cat
Author identifier: 0000-0003-3307-4340
Record's date: 2024-08-03
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/1422-0067/24/2/1127
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: International Journal Of Molecular Sciences. 24 (2):
APA: Pavel, MC; Ramirez-Maldonado, E; Pueyo-Périz, E; Memba, R; Merino, S; Geoghegan, J; Jorba, R (2023). The Impact of Molecular Biology in the Seeding, Treatment Choices and Follow-Up of Colorectal Cancer Liver Metastases—A Narrative Review. International Journal Of Molecular Sciences, 24(2), -. DOI: 10.3390/ijms24021127
Article's DOI: 10.3390/ijms24021127
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications
Repositori URV