Acute lumbar polyradiculoneuropathy as early sign of methotrexate intrathecal neurotoxicity: Case report and literature review

Identifier:  imarina:9293581

Handle: https://hdl.handle.net/20.500.11797/imarina9293581

Authors:  Montejo, Carmen; Navarro-Otano, Judith; Maya-Casalprim, Gerard; Campolo, Michela; Casanova-Molla, Jordi

Abstract:
Key Clinical Message Acute paraplegia after treatment with intrathecal methotrexate requires a complete spinal cord neuroimaging as well as electrodiagnostic examination. The absence of lumbosacral F waves motor responses without demyelinating findings may indicate early direct root toxicity. Early electromyography (EMG) screening could be a valuable tool for detecting peripheral neurotoxicity.