Articles producció científica> Medicina i Cirurgia

The Role of Olfactomedin 2 in the Adipose Tissue-Liver Axis and Its Implication in Obesity-Associated Nonalcoholic Fatty Liver Disease

  • Identification data

    Identifier: imarina:9295552
  • Authors:

    Barrientos-Riosalido, A
    Bertran, L
    Vilaró-Blay, M
    Aguilar, C
    Martínez, S
    Paris, M
    Sabench, F
    Riesco, D
    Binetti, J
    Del Castillo, D
    Richart, C
    Auguet, T
  • Others:

    Author, as appears in the article.: Barrientos-Riosalido, A; Bertran, L; Vilaró-Blay, M; Aguilar, C; Martínez, S; Paris, M; Sabench, F; Riesco, D; Binetti, J; Del Castillo, D; Richart, C; Auguet, T
    Department: Medicina i Cirurgia Ciències Mèdiques Bàsiques
    URV's Author/s: Aguilar Crespillo, Carmen Isabel / Auguet Quintillà, Maria Teresa / Bertran Ramos, Laia / Del Castillo Déjardin, Daniel / Martínez González, María Salomé / París Sans, Marta / Richart Jurado, Cristobal Manuel / Sabench Pereferrer, Fàtima
    Keywords: Visceral fat Pathogenesis Olfactomedin 2 Nonalcoholic fatty liver disease Lipid metabolism Inflammation Gene-expression Adipose tissue
    Abstract: This study's objective was to assess the involvement of olfactomedin 2 (OLFM2), a secreted glycoprotein related to lipid metabolism regulation, in nonalcoholic fatty liver disease (NAFLD) mediated by the adipose-tissue-liver axis. OLFM2 mRNA expression was analyzed in subcutaneous (SAT) and visceral (VAT) adipose tissue by RT-qPCR. The cohort included women with normal weight (n = 16) or morbid obesity (MO, n = 60) who were subclassified into normal liver (n = 20), simple steatosis (n = 21), and nonalcoholic steatohepatitis (NASH, n = 19) groups. The results showed that OLFM2 expression in SAT was enhanced in MO individuals and in the presence of NAFLD. Specifically, OLFM2 expression in SAT was increased in mild and moderate degrees of steatosis in comparison to the absence of it. Moreover, OLFM2 expression in SAT was negatively correlated with interleukin-6 levels. On the other hand, OLFM2 expression in VAT decreased in the presence of NASH and exhibited a positive correlation with adiponectin levels. In conclusion, OLFM2 in SAT seems to be implicated in hepatic lipid accumulation. Additionally, since we previously suggested the possible implication of hepatic OLFM2 in NAFLD progression, now we propose a possible interaction between the liver and SAT, reinforcing the potential implication of this tissue in NAFLD development.
    Thematic Areas: Zootecnia / recursos pesqueiros Spectroscopy Saúde coletiva Química Psicología Physical and theoretical chemistry Organic chemistry Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Inorganic chemistry Geociências Farmacia Engenharias iv Engenharias ii Engenharias i Educação física Computer science applications Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, multidisciplinary Catalysis Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: marta.paris@urv.cat mariasalome.martinez@urv.cat danieldel.castillo@urv.cat cristobalmanuel.richart@urv.cat mariateresa.auguet@urv.cat carmenisabel.aguilar@urv.cat carmenisabel.aguilar@urv.cat fatima.sabench@urv.cat laia.bertranr@estudiants.urv.cat laia.bertranr@estudiants.urv.cat
    Author identifier: 0000-0001-6185-2889 0000-0003-0456-3102 0000-0001-7024-7824 0000-0003-0852-6739 0000-0003-0396-6428 0000-0002-4440-562X 0000-0002-4440-562X 0000-0002-9262-8756 0000-0001-9052-1368 0000-0001-9052-1368
    Record's date: 2024-03-09
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/1422-0067/24/6/5221
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: International Journal Of Molecular Sciences. 24 (6):
    APA: Barrientos-Riosalido, A; Bertran, L; Vilaró-Blay, M; Aguilar, C; Martínez, S; Paris, M; Sabench, F; Riesco, D; Binetti, J; Del Castillo, D; Richart, C (2023). The Role of Olfactomedin 2 in the Adipose Tissue-Liver Axis and Its Implication in Obesity-Associated Nonalcoholic Fatty Liver Disease. International Journal Of Molecular Sciences, 24(6), -. DOI: 10.3390/ijms24065221
    Article's DOI: 10.3390/ijms24065221
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2023
    Publication Type: Journal Publications
  • Keywords:

    Biochemistry & Molecular Biology,Catalysis,Chemistry, Multidisciplinary,Computer Science Applications,Inorganic Chemistry,Medicine (Miscellaneous),Molecular Biology,Organic Chemistry,Physical and Theoretical Chemistry,Spectroscopy
    Visceral fat
    Pathogenesis
    Olfactomedin 2
    Nonalcoholic fatty liver disease
    Lipid metabolism
    Inflammation
    Gene-expression
    Adipose tissue
    Zootecnia / recursos pesqueiros
    Spectroscopy
    Saúde coletiva
    Química
    Psicología
    Physical and theoretical chemistry
    Organic chemistry
    Odontología
    Nutrição
    Molecular biology
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Inorganic chemistry
    Geociências
    Farmacia
    Engenharias iv
    Engenharias ii
    Engenharias i
    Educação física
    Computer science applications
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Ciência da computação
    Chemistry, multidisciplinary
    Catalysis
    Biotecnología
    Biodiversidade
    Biochemistry & molecular biology
    Astronomia / física
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