Author, as appears in the article.: Tahiri, Ghizlane; Lax, Carlos; Canovas-Marquez, Jose Tomas; Carrillo-Marin, Pablo; Sanchis, Marta; Navarro, Eusebio; Garre, Victoriano; Nicolas, Francisco Esteban;
Department: Ciències Mèdiques Bàsiques
URV's Author/s: Sanchis Talón, Marta
Keywords: Amphotericin-b Antifungal drug-resistance Antifungal resistance Aspergillus-fumigatus Carotenogenesis Circinelloides Dimorphism Gene Iron Mucor Mucorales Mucormycosis Negative regulator Rhizopus Rhizopus-delemar
Abstract: The classification of Mucorales encompasses a collection of basal fungi that have traditionally demonstrated an aversion to modern genetic manipulation techniques. This aversion led to a scarcity of knowledge regarding their biology compared to other fungal groups. However, the emergence of mucormycosis, a fungal disease caused by Mucorales, has attracted the attention of the clinical field, mainly because available therapies are ineffective for decreasing the fatal outcome associated with the disease. This revitalized curiosity about Mucorales and mucormycosis, also encouraged by the recent COVID-19 pandemic, has spurred a significant and productive effort to uncover their mysteries in recent years. Here, we elaborate on the most remarkable breakthroughs related to the recently discovered genetic advances in Mucorales and mucormycosis. The utilization of a few genetic study models has enabled the identification of virulence factors in Mucorales that were previously described in other pathogens. More notably, recent investigations have identified novel genes and mechanisms controlling the pathogenic potential of Mucorales and their interactions with the host, providing fresh avenues to devise new strategies against mucormycosis. Finally, new study models are allowing virulence studies that were previously hampered in Mucorales, predicting a prolific future for the field.
Thematic Areas: Ciências biológicas ii Ciências biológicas iii Ecology, evolution, behavior and systematics Farmacia Microbiology Microbiology (medical) Mycology Plant science
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: marta.sanchis@urv.cat
Author identifier: 0000-0001-7251-6792
Record's date: 2023-04-22
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2309-608X/9/3/335
Papper original source: J Fungi (Basel). 9 (3):
APA: Tahiri, Ghizlane; Lax, Carlos; Canovas-Marquez, Jose Tomas; Carrillo-Marin, Pablo; Sanchis, Marta; Navarro, Eusebio; Garre, Victoriano; Nicolas, Franc (2023). Mucorales and Mucormycosis: Recent Insights and Future Prospects. J Fungi (Basel), 9(3), -. DOI: 10.3390/jof9030335
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Article's DOI: 10.3390/jof9030335
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications
Repositori URV