Articles producció científica> Ciències Mèdiques Bàsiques

Mucorales and Mucormycosis: Recent Insights and Future Prospects

  • Identification data

    Identifier: imarina:9295562
    Authors:
    Tahiri, GhizlaneLax, CarlosCanovas-Marquez, Jose TomasCarrillo-Marin, PabloSanchis, MartaNavarro, EusebioGarre, VictorianoNicolas, Francisco Esteban
    Abstract:
    The classification of Mucorales encompasses a collection of basal fungi that have traditionally demonstrated an aversion to modern genetic manipulation techniques. This aversion led to a scarcity of knowledge regarding their biology compared to other fungal groups. However, the emergence of mucormycosis, a fungal disease caused by Mucorales, has attracted the attention of the clinical field, mainly because available therapies are ineffective for decreasing the fatal outcome associated with the disease. This revitalized curiosity about Mucorales and mucormycosis, also encouraged by the recent COVID-19 pandemic, has spurred a significant and productive effort to uncover their mysteries in recent years. Here, we elaborate on the most remarkable breakthroughs related to the recently discovered genetic advances in Mucorales and mucormycosis. The utilization of a few genetic study models has enabled the identification of virulence factors in Mucorales that were previously described in other pathogens. More notably, recent investigations have identified novel genes and mechanisms controlling the pathogenic potential of Mucorales and their interactions with the host, providing fresh avenues to devise new strategies against mucormycosis. Finally, new study models are allowing virulence studies that were previously hampered in Mucorales, predicting a prolific future for the field.
  • Others:

    Author, as appears in the article.: Tahiri, Ghizlane; Lax, Carlos; Canovas-Marquez, Jose Tomas; Carrillo-Marin, Pablo; Sanchis, Marta; Navarro, Eusebio; Garre, Victoriano; Nicolas, Francisco Esteban;
    Department: Ciències Mèdiques Bàsiques
    URV's Author/s: Sanchis Talón, Marta
    Keywords: Rhizopus-delemar Rhizopus Negative regulator Mucormycosis Mucorales Mucor Iron Gene Dimorphism Circinelloides Carotenogenesis Aspergillus-fumigatus Antifungal resistance Antifungal drug-resistance Amphotericin-b
    Abstract: The classification of Mucorales encompasses a collection of basal fungi that have traditionally demonstrated an aversion to modern genetic manipulation techniques. This aversion led to a scarcity of knowledge regarding their biology compared to other fungal groups. However, the emergence of mucormycosis, a fungal disease caused by Mucorales, has attracted the attention of the clinical field, mainly because available therapies are ineffective for decreasing the fatal outcome associated with the disease. This revitalized curiosity about Mucorales and mucormycosis, also encouraged by the recent COVID-19 pandemic, has spurred a significant and productive effort to uncover their mysteries in recent years. Here, we elaborate on the most remarkable breakthroughs related to the recently discovered genetic advances in Mucorales and mucormycosis. The utilization of a few genetic study models has enabled the identification of virulence factors in Mucorales that were previously described in other pathogens. More notably, recent investigations have identified novel genes and mechanisms controlling the pathogenic potential of Mucorales and their interactions with the host, providing fresh avenues to devise new strategies against mucormycosis. Finally, new study models are allowing virulence studies that were previously hampered in Mucorales, predicting a prolific future for the field.
    Thematic Areas: Plant science Mycology Microbiology (medical) Microbiology Farmacia Ecology, evolution, behavior and systematics Ciências biológicas iii Ciências biológicas ii
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: marta.sanchis@urv.cat
    Author identifier: 0000-0001-7251-6792
    Record's date: 2024-08-03
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/2309-608X/9/3/335
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: J Fungi (Basel). 9 (3):
    APA: Tahiri, Ghizlane; Lax, Carlos; Canovas-Marquez, Jose Tomas; Carrillo-Marin, Pablo; Sanchis, Marta; Navarro, Eusebio; Garre, Victoriano; Nicolas, Franc (2023). Mucorales and Mucormycosis: Recent Insights and Future Prospects. J Fungi (Basel), 9(3), -. DOI: 10.3390/jof9030335
    Article's DOI: 10.3390/jof9030335
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2023
    Publication Type: Journal Publications
  • Keywords:

    Ecology, Evolution, Behavior and Systematics,Microbiology,Microbiology (Medical),Mycology,Plant Science
    Rhizopus-delemar
    Rhizopus
    Negative regulator
    Mucormycosis
    Mucorales
    Mucor
    Iron
    Gene
    Dimorphism
    Circinelloides
    Carotenogenesis
    Aspergillus-fumigatus
    Antifungal resistance
    Antifungal drug-resistance
    Amphotericin-b
    Plant science
    Mycology
    Microbiology (medical)
    Microbiology
    Farmacia
    Ecology, evolution, behavior and systematics
    Ciências biológicas iii
    Ciências biológicas ii
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