Articles producció científica> Ciències Mèdiques Bàsiques

Is telomere length a biomarker of sperm quality? A systematic review and meta-analysis of observational studies

  • Identification data

    Identifier: imarina:9321831
  • Authors:

    de la Puente, MF
    Salas-Huetos, A
    Valle-Hita, C
    Babio, N
    Murphy, MM
    Canudas, S
    Salas-Salvadó, J
    Andrology
    10.1111/andr.13482
    Andrology. 12 (2): 277-288
  • Others:

    Author, as appears in the article.: de la Puente, MF; Salas-Huetos, A; Valle-Hita, C; Babio, N; Murphy, MM; Canudas, S; Salas-Salvadó, J
    Department: Bioquímica i Biotecnologia Ciències Mèdiques Bàsiques
    URV's Author/s: Babio Sánchez, Nancy Elvira / Fernández de la Puente Cervera, María / Murphy, Michelle / Salas Huetos, Albert / Salas Salvadó, Jorge / Valle Hita, Cristina
    Keywords: Telomere length Spermatozoa Sperm quality Sperm Leukocyte telomere Leukocyte Biomarker telomere length spermatozoa sperm quality semen risk men marker leukocyte
    Abstract: Telomeres are essential for the integrity of chromosome ends during cell division and their involvement in different processes linked to aging has been established. These chromosome components are involved in spermatogenesis and seem to play an important role in fertilization and embryo development. Telomere length is shortened with each cell division. Recently, short sperm telomere length has been proposed as a potential biomarker of male infertility.To conduct a systematic review and meta-analysis of studies exploring the association between sperm and/or leukocyte telomere length with sperm quality parameters and different infertility conditions.A systematic review and meta-analysis was conducted with studies from Medline-PUBMED and Cochrane Library databases until May 2022. Eligible studies included cohort, cross-sectional and case-control studies, and telomere length in sperm and/or leukocytes cells was defined as the exposure. Semen quality parameters or infertility conditions (e.g., oligozoospermia, asthenozoospermia, teratozoospermia, or other spermatogenic impairment combinations) were defined as the outcomes.Twenty-four observational studies were included. In the qualitative analysis, high heterogeneity was observed between studies regarding the associations between telomere length and semen parameters in different normozoospermic/fertile and oligozoospermic/infertile populations. In the meta-analysis, sperm and leukocyte telomere length were shorter in infertile compared to fertile individuals (mean difference, MD; 95% confidence interval, CI) (-1.43; -1.66 to -1.21; P-value<0.001, and -1.67; -2.02 to -1.31; P-value<0.001, respectively). Moreover, in terms of sperm telomere length, these differences were also significant between individuals with a normal seminogram and individuals with low quantity of spermatozoa in the ejaculate (-0.97; -1.32, -0.61; P-value<0.001).The current systematic review and meta-analysis suggest the potential role of sperm or leukocyte telomere length as a reliable biomarker of semen quality, which may help distinguish between infertility conditions beyond the routine semen analysis. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.
    Thematic Areas: Zootecnia / recursos pesqueiros Urology Reproductive medicine Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Endocrinology, diabetes and metabolism Endocrinology Ciências biológicas ii Ciências biológicas i Biotecnología Biodiversidade Andrology
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: maria.fernandezdelapuente@urv.cat albert.salas@urv.cat maria.fernandezdelapuente@urv.cat cristina.valle@urv.cat michelle.murphy@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat
    Author identifier: 0000-0001-5914-6862 0000-0002-6304-6204 0000-0003-2700-7459 0000-0003-3527-5277
    Record's date: 2024-07-20
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://onlinelibrary.wiley.com/doi/epdf/10.1111/andr.13482
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Andrology. 12 (2): 277-288
    APA: de la Puente, MF; Salas-Huetos, A; Valle-Hita, C; Babio, N; Murphy, MM; Canudas, S; Salas-Salvadó, J (2024). Is telomere length a biomarker of sperm quality? A systematic review and meta-analysis of observational studies. Andrology, 12(2), 277-288. DOI: 10.1111/andr.13482
    Article's DOI: 10.1111/andr.13482
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2024
    Publication Type: Journal Publications
  • Keywords:

    Andrology,Endocrinology,Endocrinology, Diabetes and Metabolism,Reproductive Medicine,Urology
    Telomere length
    Spermatozoa
    Sperm quality
    Sperm
    Leukocyte telomere
    Leukocyte
    Biomarker
    telomere length
    spermatozoa
    sperm quality
    semen
    risk
    men
    marker
    leukocyte
    Zootecnia / recursos pesqueiros
    Urology
    Reproductive medicine
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Farmacia
    Endocrinology, diabetes and metabolism
    Endocrinology
    Ciências biológicas ii
    Ciências biológicas i
    Biotecnología
    Biodiversidade
    Andrology
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