Author, as appears in the article.: Moreno-Vedia, J; Llop, D; Rodríguez-Calvo, R; Plana, N; Amigó, N; Rosales, R; Esteban, Y; Girona, J; Masana, L; Ibarretxe, D
Department: Ciències Mèdiques Bàsiques Medicina i Cirurgia
URV's Author/s: Girona Tell, Josefa / Ibarretxe Gerediaga, Daiana / Llop Paredes, Dídac / Masana Marín, Luis / Moreno Vedia, Juan / Plana Gil, Núria / Rodríguez Calvo, Ricardo / ROSALES RIBAS, ROSER
Keywords: Insulin-resistance risk profile metabolomics metabolites diagnosis
Abstract: Circulating biomarkers of metabolic and cardiovascular diseases can help in the early detection and prevention of those diseases. Using proton nuclear magnetic resonance (1H-NMR), we aimed to study the plasma levels of low-molecular-weight metabolites (LMWMs) in a cohort of 307 patients with metabolic diseases to assess their relationships with type-2 diabetes (T2D) and incident atherosclerotic cardiovascular disease (ASCVD).We conducted a cross-sectional and prospective study. We included 307 patients attending the Lipid Unit of our University Hospital for the treatment of the following metabolic disturbances and associated disorders: T2D (73.9%), obesity (58.7%), and hypertension (55.1%). 1H-NMR was used to study the plasma levels of 13 LMWMs. LMWM serum concentrations were evaluated in patients with and without T2D. and the correlations with several parameters and their associations with T2D were analyzed. The association between LMWM levels at baseline and the development of ASCVD in patients with T2D after 10 years of follow-up was also evaluated.Among the LMWMs measured, the branched-chain amino acids (BCAAs) valine, leucine and isoleucine showed a positive association with several clinical and lipid-related biochemical parameters and inflammatory markers (p < 0.05). Likewise, these three BCAAS were associated with diabetes even after adjusting for covariates (p < 0.05). During the follow-up period of 10 years, 29 of the 185 patients with diabetes at baseline (15.68%) developed ASCVD. After adjusting for clinical covariates, baseline levels of valine and alanine were associated with the development of ASCVD (p < 0.05).Overall, our results indicated that plasma levels of LMWMs measured by 1H-NMR could be potential biomarkers associated with T2D. Moreover, alanine and valine can help in the early detection of the cardiovascular risk associated with this metabolic disease.© 2023. BioMed Central Ltd., part of Springer Nature.
Thematic Areas: Saúde coletiva Medicina ii Medicina i Internal medicine Interdisciplinar Farmacia Endocrinology, diabetes and metabolism Endocrinology & metabolism Educação física Ciências biológicas ii Ciências biológicas i Cardiology and cardiovascular medicine Cardiac & cardiovascular systems Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: daiana.ibarretxe@urv.cat luis.masana@urv.cat didac.llop@urv.cat josefa.girona@urv.cat ricardo.rodriguez@urv.cat didac.llop@urv.cat josefa.girona@urv.cat juan.moreno@estudiants.urv.cat juan.moreno@estudiants.urv.cat
Author identifier: 0000-0002-0789-4954 0000-0002-6267-8779 0000-0002-6267-8779 0000-0002-2673-3822 0000-0002-2673-3822
Record's date: 2024-08-03
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://cardiab.biomedcentral.com/articles/10.1186/s12933-023-01958-6
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Cardiovascular Diabetology. 22 (1): 249-249
APA: Moreno-Vedia, J; Llop, D; Rodríguez-Calvo, R; Plana, N; Amigó, N; Rosales, R; Esteban, Y; Girona, J; Masana, L; Ibarretxe, D (2023). Serum branch-chained amino acids are increased in type 2 diabetes and associated with atherosclerotic cardiovascular disease. Cardiovascular Diabetology, 22(1), 249-249. DOI: 10.1186/s12933-023-01958-6
Article's DOI: 10.1186/s12933-023-01958-6
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications
Repositori URV