Articles producció científica> Bioquímica i Biotecnologia

Lifestyles, Left Atrial Structure and Function, and Cognitive Decline in Adults with Metabolic Syndrome

  • Identification data

    Identifier: imarina:9330510
  • Authors:

    Casanova, IG
    Alonso-Gómez, AM
    Romaguera, D
    Toledo, E
    Li, LZ
    Fortuny, E
    López, L
    Ramallal, R
    Salas-Salvadó, J
    Tojal-Sierra, L
    Castañer, O
    Alonso, A
  • Others:

    Author, as appears in the article.: Casanova, IG; Alonso-Gómez, AM; Romaguera, D; Toledo, E; Li, LZ; Fortuny, E; López, L; Ramallal, R; Salas-Salvadó, J; Tojal-Sierra, L; Castañer, O; Alonso, A
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Salas Salvadó, Jorge
    Keywords: Weight Risk Prevention Physical-activity Physical activity Mediterranean diet Lifestyle Left atrium Impairment Fibrillation Diet Cognitive decline Association Alzheimers-disease Adherence
    Abstract: Evidence supports associations of lifestyle (including diet and physical activity) and weight with cognitive functioning, but the pathways responsible for these associations have not been fully elucidated. Because healthier lifestyles have been associated with better left atrial structure and function, which in turn is associated with better cognitive functioning, we tested the hypothesis that left atrial structure and function is a potential mediator of the association between lifestyle and cognition. We included 476 participants classed as overweight or obese with metabolic syndrome from three centers in Spain. These participants underwent lifestyle assessments and transthoracic echocardiography at baseline and repeated measurements of the Trail Making A test, a measure of executive function, taken at baseline and at the two-year follow-up. We conducted mediation analyses to test if measures of left atrial structure and function mediated associations between adherence to the Mediterranean diet scores, physical activity, and weight at baseline, as well as a two-year change in Trail Making A scores. The analysis did not find an association between these factors and Trail Making A scores, and no indirect effects appeared to be mediated by echocardiographic measurements. The modest sample size in this analysis is a limitation, and larger studies should be conducted to determine potential cardiovascular factors mediating the association between lifestyle and cognition.
    Thematic Areas: Medicine, general & internal Medicine (miscellaneous) Medicine (all)
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: jordi.salas@urv.cat
    Author identifier: 0000-0003-2700-7459
    Record's date: 2024-01-29
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/2077-0383/12/18/6066
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Journal Of Clinical Medicine. 12 (18):
    APA: Casanova, IG; Alonso-Gómez, AM; Romaguera, D; Toledo, E; Li, LZ; Fortuny, E; López, L; Ramallal, R; Salas-Salvadó, J; Tojal-Sierra, L; Castañer, O; Al (2023). Lifestyles, Left Atrial Structure and Function, and Cognitive Decline in Adults with Metabolic Syndrome. Journal Of Clinical Medicine, 12(18), -. DOI: 10.3390/jcm12186066
    Article's DOI: 10.3390/jcm12186066
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2023
    Publication Type: Journal Publications
  • Keywords:

    Medicine (Miscellaneous),Medicine, General & Internal
    Weight
    Risk
    Prevention
    Physical-activity
    Physical activity
    Mediterranean diet
    Lifestyle
    Left atrium
    Impairment
    Fibrillation
    Diet
    Cognitive decline
    Association
    Alzheimers-disease
    Adherence
    Medicine, general & internal
    Medicine (miscellaneous)
    Medicine (all)
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